{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:24:37Z","timestamp":1775885077257,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18H05282"],"award-info":[{"award-number":["JP18H05282"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K17905"],"award-info":[{"award-number":["JP19K17905"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["J200705023"],"award-info":[{"award-number":["J200705023"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["J200705710"],"award-info":[{"award-number":["J200705710"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["J200705049"],"award-info":[{"award-number":["J200705049"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18 cm016335"],"award-info":[{"award-number":["JP18 cm016335"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18 cm059042"],"award-info":[{"award-number":["JP18 cm059042"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease, and many peripheral immune cell populations (ICPs) are thought to be altered according to the course of the disease. However, it is unclear which ICPs are associated with the clinical phenotypes of SLE. We analyzed peripheral blood mononuclear cells (PBMCs) of 28 SLE patients using mass cytometry and identified 30 ICPs. We determined the proliferative activity of ICPs by measuring the proportion of cells expressing specific markers and Ki-67 among CD45+ cells (Ki-67+ proportion). We observed an increased Ki-67+ proportion for many ICPs of SLE patients and examined the association between their Ki-67+ proportions and clinical findings. The Ki-67+ proportions of five ICPs [classical monocyte (cMo), effector memory CD8+ T cell (CD8Tem), CXCR5\u2212 naive B cell (CXCR5\u2212 nB), and CXCR5\u2212 IgD\u2212CD27\u2212 B cell (CXCR5\u2212 DNB)] were identified as clinically important factors. The SLE Disease Activity Index (SLEDAI) was positively correlated with cMo and plasma cells (PC). The titer of anti-DNA antibodies was positively correlated with cMo, CXCR5\u2212 nB, and CXCR5\u2212 DNB. The C4 level was negatively correlated with CXCR5\u2212 DNB. The bioactivity of type I interferon was also positively correlated with these ICPs. Fever and renal involvement were associated with cMo. Rash was associated with CD8Tem and CXCR5\u2212 DNB. On the basis of the proliferative activity among five ICPs, SLE patients can be classified into five clusters showing different SLE phenotypes. Evaluation of the proliferative activity in each ICP can be linked to the clinical phenotypes of individual SLE patients and help in the treatment strategy.<\/jats:p>","DOI":"10.1093\/intimm\/dxac042","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T15:25:56Z","timestamp":1661268356000},"page":"27-41","source":"Crossref","is-referenced-by-count":14,"title":["The proliferative activity levels of each immune cell population evaluated by mass cytometry are linked to the clinical phenotypes of systemic lupus erythematosus"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0916-949X","authenticated-orcid":false,"given":"Akiko","family":"Kajihara","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7111-9506","authenticated-orcid":false,"given":"Takayoshi","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hachiro","family":"Konaka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Department of General Medicine, Nippon Life Hospital, Public Interest Incorporated Foundation , 2-1-54 Enokojima, Osaka Nishi-ku, Osaka 550-0006 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruaki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyota","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Nishide","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akane","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Laboratory of Thermotherapeutics for Vascular Dysfunction, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumiyuki","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-3154","authenticated-orcid":false,"given":"Toru","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Division of Rheumatology, Department of Internal Medicine, Nishinomiya Municipal Central Hospital , 8-24 Hayasidacho, Nishinomiya, Hyogo 663-8014 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Shima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Laboratory of Thermotherapeutics for Vascular Dysfunction, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Narazaki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Department of Advanced Clinical and Translational Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kumanogoh","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"},{"name":"Center for Infectious Diseases for Education and Research (CiDER), Osaka University , 2-2 Yamadaoka, Suita, Osaka 565-0871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"2023012110000244000_CIT0001","doi-asserted-by":"crossref","first-page":"16039","DOI":"10.1038\/nrdp.2016.39","article-title":"Systemic lupus erythematosus","volume":"2","author":"Kaul","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2023012110000244000_CIT0002","doi-asserted-by":"crossref","first-page":"772","DOI":"10.3389\/fimmu.2019.00772","article-title":"Innate immune cells\u2019 contribution to systemic lupus erythematosus","volume":"10","author":"Herrada","year":"2019","journal-title":"Front. Immunol."},{"key":"2023012110000244000_CIT0003","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3390\/cells8020140","article-title":"Immune profiling and precision medicine in systemic lupus erythematosus","volume":"8","author":"Nagafuchi","year":"2019","journal-title":"Cells"},{"key":"2023012110000244000_CIT0004","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrg2571","article-title":"Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies","volume":"10","author":"Harley","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"2023012110000244000_CIT0005","doi-asserted-by":"crossref","first-page":"e75319","DOI":"10.1371\/journal.pone.0075319","article-title":"Circulating TFH subset distribution is strongly affected in lupus patients with an active disease","volume":"8","author":"Le Coz","year":"2013","journal-title":"PLoS One"},{"key":"2023012110000244000_CIT0006","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/ard.59.4.283","article-title":"Monocytes from systemic lupus erythematous patients are severely altered in phenotype and lineage flexibility","volume":"59","author":"Steinbach","year":"2000","journal-title":"Ann. Rheum. Dis."},{"key":"2023012110000244000_CIT0007","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/art.10949","article-title":"Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus","volume":"48","author":"Jacobi","year":"2003","journal-title":"Arthritis Rheum."},{"key":"2023012110000244000_CIT0008","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.immuni.2018.08.015","article-title":"Distinct effector B cells induced by unregulated Toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus","volume":"49","author":"Jenks","year":"2018","journal-title":"Immunity"},{"key":"2023012110000244000_CIT0009","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fmed.2020.00085","article-title":"Double Negative B cell is associated with renal impairment in systemic lupus erythematosus and acts as a marker for nephritis remission","volume":"7","author":"You","year":"2020","journal-title":"Front. Med."},{"key":"2023012110000244000_CIT0010","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.immuni.2020.04.015","article-title":"Plasmacytoid dendritic cells and type I Interferon promote extrafollicular B cell responses to extracellular Self-DNA","volume":"52","author":"Soni","year":"2020","journal-title":"Immunity"},{"key":"2023012110000244000_CIT0011","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.immuni.2020.11.006","article-title":"Germinal center and extrafollicular B cell responses in vaccination, immunity, and autoimmunity","volume":"53","author":"Elsner","year":"2020","journal-title":"Immunity"},{"key":"2023012110000244000_CIT0012","first-page":"9324315","article-title":"Infiltrating CD16(+) are associated with a reduction in peripheral CD14(+)CD16(++) monocytes and severe forms of lupus nephritis","volume":"2016","author":"Barrera Garc\u00eda","year":"2016","journal-title":"Autoimmune Dis."},{"key":"2023012110000244000_CIT0013","doi-asserted-by":"crossref","first-page":"e130062","DOI":"10.1172\/jci.insight.130062","article-title":"PD-1hi CXCR5- T peripheral helper cells promote B cells responses in lupus via MAF and IL-21","volume":"4","author":"Bocharnikov","year":"2019","journal-title":"JCI Insight"},{"key":"2023012110000244000_CIT0014","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/art.23186","article-title":"Glomerular accumulation of plasmacytoid dendritic cells in active lupus nephritis: role of interleukin-18","volume":"58","author":"Tucci","year":"2008","journal-title":"Arthritis Rheum."},{"key":"2023012110000244000_CIT0015","first-page":"R6","article-title":"Increased expression of FcgammaRI\/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus","volume":"11","author":"Li","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"2023012110000244000_CIT0016","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1007\/s10067-020-05480-y","article-title":"Lymphocyte subset clustering analysis in treatment-naive patients with systemic lupus erythematosus","volume":"40","author":"Lu","year":"2021","journal-title":"Clin. Rheumatol."},{"key":"2023012110000244000_CIT0017","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1093\/intimm\/dxt050","article-title":"Confounding roles for type I interferons during bacterial and viral pathogenesis","volume":"25","author":"Carrero","year":"2013","journal-title":"Int. Immunol."},{"key":"2023012110000244000_CIT0018","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00412-018-0659-8","article-title":"Ki-67: more than a proliferation marker","volume":"127","author":"Sun","year":"2018","journal-title":"Chromosoma"},{"key":"2023012110000244000_CIT0019","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1470-2045(09)70262-1","article-title":"Ki-67 in breast cancer: prognostic and predictive potential","volume":"11","author":"Yerushalmi","year":"2010","journal-title":"Lancet Oncol."},{"key":"2023012110000244000_CIT0020","first-page":"198","article-title":"Ki-67 proliferation index in renal biopsy samples of patients with systemic lupus erythematosus and its correlation with clinical findings","volume":"7","author":"Dalkilic","year":"2013","journal-title":"Iran J. Kidney Dis."},{"key":"2023012110000244000_CIT0021","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/cei.13263","article-title":"Natural killer cell expression of Ki-67 is associated with elevated serum IL-15, disease activity and nephritis in systemic lupus erythematosus","volume":"196","author":"Hudspeth","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"2023012110000244000_CIT0022","doi-asserted-by":"crossref","first-page":"635615","DOI":"10.3389\/fimmu.2021.635615","article-title":"Deep phenotyping of CD11c(+) B cells in systemic autoimmunity and controls","volume":"12","author":"Rincon-Arevalo","year":"2021","journal-title":"Front. Immunol."},{"key":"2023012110000244000_CIT0023","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41419-018-0327-1","article-title":"The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence","volume":"9","author":"Ong","year":"2018","journal-title":"Cell Death Dis."},{"key":"2023012110000244000_CIT0024","doi-asserted-by":"crossref","first-page":"e125325","DOI":"10.1172\/jci.insight.125325","article-title":"Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients","volume":"4","author":"Wood","year":"2019","journal-title":"JCI Insight"},{"key":"2023012110000244000_CIT0025","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.jaci.2015.04.008","article-title":"Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus","volume":"136","author":"O\u2019Gorman","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"2023012110000244000_CIT0026","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13075-015-0644-z","article-title":"Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy","volume":"17","author":"Nair","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"2023012110000244000_CIT0027","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"Hochberg","year":"1997","journal-title":"Arthritis Rheum."},{"key":"2023012110000244000_CIT0028","first-page":"288","article-title":"Systemic lupus erythematosus disease activity index 2000","volume":"29","author":"Gladman","year":"2002","journal-title":"J. Rheumatol."},{"key":"2023012110000244000_CIT0029","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1136\/annrheumdis-2018-212988","article-title":"Apoptosis-derived membrane vesicles drive the cGAS-STING pathway and enhance type I IFN production in systemic lupus erythematosus","volume":"77","author":"Kato","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"2023012110000244000_CIT0030","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/cyto.a.22778","article-title":"Platinum-conjugated antibodies for application in mass cytometry","volume":"89","author":"Mei","year":"2016","journal-title":"Cytometry Part A"},{"key":"2023012110000244000_CIT0031","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant."},{"key":"2023012110000244000_CIT0032","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/clim.2001.5172","article-title":"Aberrant expression of the costimulatory molecule CD40 ligand on monocytes from patients with systemic lupus erythematosus","volume":"103","author":"Katsiari","year":"2002","journal-title":"Clin. Immunol."},{"key":"2023012110000244000_CIT0033","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"New insights into the immunopathogenesis of systemic lupus erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"2023012110000244000_CIT0034","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/BOR.0000000000000815","article-title":"The role of CD8+ T-cell systemic lupus erythematosus pathogenesis: an update","volume":"33","author":"Chen","year":"2021","journal-title":"Curr. Opin. Rheumatol."},{"key":"2023012110000244000_CIT0035","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1177\/0961203308089400","article-title":"CD8+CD28-, suppressive T cells in systemic lupus erythematosus","volume":"17","author":"Tulunay","year":"2008","journal-title":"Lupus"},{"key":"2023012110000244000_CIT0036","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41584-020-00544-4","article-title":"Toll-like receptor signalling in B cells during systemic lupus erythematosus","volume":"17","author":"Fillatreau","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"2023012110000244000_CIT0037","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3389\/fimmu.2018.00427","article-title":"Plasma cell differentiation pathways in systemic lupus erythematosus","volume":"9","author":"Malkiel","year":"2018","journal-title":"Front. Immunol."},{"key":"2023012110000244000_CIT0038","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/imr.12741","article-title":"Extrafollicular responses in humans and SLE","volume":"288","author":"Jenks","year":"2019","journal-title":"Immunol. Rev."},{"key":"2023012110000244000_CIT0039","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2302\/kjm.24.263","article-title":"Peripheral blood T-lymphocytes during the course of systemic lupus erythematosus","volume":"24","author":"Hara","year":"1975","journal-title":"Keio J. Med."},{"key":"2023012110000244000_CIT0040","doi-asserted-by":"crossref","first-page":"663656","DOI":"10.3389\/fvets.2021.663656","article-title":"Flow cytometric assessment of Ki-67 expression in lymphocytes from physiologic lymph nodes, lymphoma cell populations and remnant normal cell populations from lymphomatous lymph nodes","volume":"8","author":"R\u00fctgen","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"2023012110000244000_CIT0041","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00456388","article-title":"The Ki-67 antigen in primary human melanomas\u2014its relationship to mitotic rate and tumor thickness and its stability","volume":"281","author":"Ostmeier","year":"1989","journal-title":"Arch. Dermatol. Res."},{"key":"2023012110000244000_CIT0042","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1128\/cdli.3.6.710-716.1996","article-title":"Studies of proliferative responses by long-term-cryopreserved peripheral blood mononuclear cells to bacterial components associated with periodontitis","volume":"3","author":"Miller","year":"1996","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"2023012110000244000_CIT0043","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1128\/CDLI.7.4.714-716.2000","article-title":"Viability and functional activity of cryopreserved mononuclear cells","volume":"7","author":"Weinberg","year":"2000","journal-title":"Clin. Diagn. Lab. Immunol."}],"container-title":["International Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/intimm\/advance-article-pdf\/doi\/10.1093\/intimm\/dxac042\/46537804\/dxac042.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/intimm\/article-pdf\/35\/1\/27\/48809449\/dxac042.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/intimm\/article-pdf\/35\/1\/27\/48809449\/dxac042.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T10:00:49Z","timestamp":1674295249000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/intimm\/article\/35\/1\/27\/6673967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,23]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,8,23]]},"published-print":{"date-parts":[[2023,1,21]]}},"URL":"https:\/\/doi.org\/10.1093\/intimm\/dxac042","relation":{},"ISSN":["1460-2377"],"issn-type":[{"value":"1460-2377","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,8,23]]}}}