{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:18:41Z","timestamp":1770149921204,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Systemic lupus erythematosus (SLE) is a complex autoimmune disease that has a strong preference for women of child-bearing age. Maternal factors play an essential role in shaping the immune system of the newborn, yet it is unknown whether maternal factors could modulate the development of SLE in the offspring. Activation-induced cytidine deaminase (AID) is an enzyme required for somatic hypermutation and class switch recombination. Given that IgG and IgA isotypes account for the vast majority of passive immunity in rodents, our previously established AID-deficient BXSB mice provide a model in which maternal antibodies that can be transferred to the offspring are greatly diminished and have restricted repertoire. In this study, we compared genotypically identical mice born to either AID-sufficient dams or AID-deficient dams and evaluated the effects of maternal antibodies in disease progression. Offspring from knockout dams developed disease at a faster rate, as shown by more severe nephritis and elevated pathogenic autoantibodies compared to their counterparts born to wild-type dams. When immune competent pups were cross fostered onto AID-deficient dams, these mice exhibited more severe disease characteristics, including exacerbated lupus nephritis, increased levels of circulating antinuclear antibodies, and more activated T cells. These results suggest that a protective antibody effect contributes to the modulation of SLE progression in postnatal period. Overall, these findings highlight the importance of maternal antibodies in programming the immune system and altering SLE development in offspring.<\/jats:p>","DOI":"10.1093\/intimm\/dxac049","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T13:37:20Z","timestamp":1664804240000},"page":"95-104","source":"Crossref","is-referenced-by-count":3,"title":["Maternal antibody repertoire restriction modulates the development of lupus-like disease in BXSB offspring"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8014-2855","authenticated-orcid":false,"given":"Jing","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Animal and Poultry Sciences, Virginia Tech , 175 West Campus Drive, 3280 Litton Reaves Hall, Blacksburg, VA 24061 , USA"},{"name":"Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University , Blacksburg, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Naughton","sequence":"additional","affiliation":[{"name":"Department of Animal and Poultry Sciences, Virginia Tech , 175 West Campus Drive, 3280 Litton Reaves Hall, Blacksburg, VA 24061 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Bowman","sequence":"additional","affiliation":[{"name":"Department of Animal and Poultry Sciences, Virginia Tech , 175 West Campus Drive, 3280 Litton Reaves Hall, Blacksburg, VA 24061 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"LeRoith","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University , Blacksburg, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University , Blacksburg, VA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-7623","authenticated-orcid":false,"given":"Caroline","family":"Leeth","sequence":"additional","affiliation":[{"name":"Department of Animal and Poultry Sciences, Virginia Tech , 175 West Campus Drive, 3280 Litton Reaves Hall, Blacksburg, VA 24061 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"2023021107412100500_CIT0001","doi-asserted-by":"crossref","first-page":"16039","DOI":"10.1038\/nrdp.2016.39","article-title":"Systemic lupus erythematosus","volume":"2","author":"Kaul","year":"2016","journal-title":"Nat. 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Rheumatol."},{"key":"2023021107412100500_CIT0005","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.celrep.2019.07.047","article-title":"Maternal antibodies inhibit neonatal and infant responses to vaccination by shaping the early-life B cell repertoire within germinal centers","volume":"28","author":"Vono","year":"2019","journal-title":"Cell Rep."},{"key":"2023021107412100500_CIT0006","doi-asserted-by":"crossref","first-page":"6143","DOI":"10.1182\/blood-2010-11-320317","article-title":"Insights into the regulatory mechanism controlling the inhibition of vaccine-induced seroconversion by maternal antibodies","volume":"117","author":"Kim","year":"2011","journal-title":"Blood."},{"key":"2023021107412100500_CIT0007","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1016\/S0264-410X(03)00342-6","article-title":"Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants","volume":"21","author":"Siegrist","year":"2003","journal-title":"Vaccine."},{"key":"2023021107412100500_CIT0008","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00281-017-0654-9","article-title":"Vaccine responses in newborns","volume":"39","author":"Saso","year":"2017","journal-title":"Semin. 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