{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:43:00Z","timestamp":1793400180804,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970062"],"award-info":[{"award-number":["81970062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Excessive NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation has an important function in the pathogenesis of Sj\u00f6gren\u2019s syndrome (SS). Increased and dysfunctional myeloid-derived suppressor cells (MDSCs) promoted SS. However, NLRP3 inflammasome activation of MDSCs in SS and its regulated components are unclear. Splenic MDSCs were purified by immunomagnetic beads and cultured. Western blot was used to assess NLRP3 inflammasomes. Interleukin-1\u03b2 (IL-1\u03b2) and IL-18 were measured using enzyme-linked immunosorbent assay. Here we showed that the NLRP3 inflammasome was activated in non-obese diabetic (NOD) mice with SS-like manifestations. We found that NLRP3 inflammasome activation was augmented in MDSCs of SS mice and NLRP3 inflammasome activation was suppressed in IL-27-deficient NOD mice. Consistent with findings of SS mice in vivo, we observed that NLRP3 inflammasome activation by adenosine triphosphate and lipopolysaccharide was remarkably intensified in MDSCs with IL-27 treatment in vitro. Collectively, our data highlighted that IL-27 regulates NLRP3 inflammasome activation of MDSCs in experimental SS.<\/jats:p>","DOI":"10.1093\/intimm\/dxad037","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T20:05:45Z","timestamp":1695845145000},"page":"531-542","source":"Crossref","is-referenced-by-count":10,"title":["IL-27 regulates NLRP3 inflammasome activation of MDSCs in experimental Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1093","volume":"35","author":[{"given":"Xiaoyu","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqiang","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zha","sequence":"additional","affiliation":[{"name":"Teaching and Research Section of Pathogen Biology and Immunology, Basic Medical College, Anqing Medical College , Anqing 246052 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine , Nanjing 210023 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine , Nanjing 210023 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genhong","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing , 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