{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:07:16Z","timestamp":1767373636874,"version":"3.37.3"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T00:00:00Z","timestamp":1701475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18H04665","23H04794","20H03455","20K21618","21K15476","23K14552"],"award-info":[{"award-number":["18H04665","23H04794","20H03455","20K21618","21K15476","23K14552"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"TERUMO Life Science Foundation, Kato Memorial Bioscience Foundation, Takeda Science Foundation, Mochida memorial foundation for medical and pharmaceutical research, Uehara memorial foundation"},{"name":"Cell science research foundation, The Astellas Foundation"},{"DOI":"10.13039\/501100013236","name":"MSD Life Science Foundation, Public Interest Incorporated Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013236","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Canon Foundation, ONO Medical Research Foundation, the Research Grant of the Princess Takamatsu Cancer Research Fund, The Yasuda Medical Foundation, The Mitsubishi Foundation"},{"name":"The Chemo-Sero-Therapeutic Research Institute"},{"DOI":"10.13039\/501100022598","name":"Toray Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022598","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To meet the energetic requirements associated with activation, proliferation, and survival, T cells switch their metabolic signatures from energetically quiescent to activated. However, little is known about the role of metabolic pathway controlling the development of invariant natural killer T (iNKT) cells. In the present study, we found that acetyl-CoA carboxylase 1 (ACC1), a rate-limiting enzyme for the fatty acid biosynthesis pathway, plays an essential role in the development of iNKT cells in the thymus. Mice lacking T-cell specific ACC1 showed a reduced number of iNKT cells with an increased proportion of iNKT cells at immature stages 0 and 1. Furthermore, mixed bone marrow (BM) chimera experiments revealed that T-cell intrinsic ACC1 expression was selectively important for the development of thymic iNKT cells, especially for the differentiation of the NKT1 cell subset. Our single-cell RNA-sequencing (scRNA-seq) data and functional analysis demonstrated that ACC1 is responsible for survival of developing iNKT cells. Thus, these findings highlighted a novel role of ACC1 in controlling thymic iNKT cell development mediated by the control of cell survival.<\/jats:p>","DOI":"10.1093\/intimm\/dxad049","type":"journal-article","created":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T17:11:37Z","timestamp":1701537097000},"page":"129-139","source":"Crossref","is-referenced-by-count":4,"title":["ACC1-mediated fatty acid biosynthesis intrinsically controls thymic iNKT cell development"],"prefix":"10.1093","volume":"36","author":[{"given":"Toshio","family":"Kanno","sequence":"first","affiliation":[{"name":"Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute , 2-6-7 Kazusa Kamatari, Kisarazu, Chiba 292-0818 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Miyako","sequence":"additional","affiliation":[{"name":"Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute , 2-6-7 Kazusa Kamatari, Kisarazu, Chiba 292-0818 , Japan"},{"name":"Department of Applied Genomics, Kazusa DNA Research Institute , 2-6-7 Kazusa Kamatari, Kisarazu, Chiba 292-0818 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeru","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute , 2-6-7 Kazusa Kamatari, Kisarazu, Chiba 292-0818 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute , 2-6-7 Kazusa Kamatari, Kisarazu, Chiba 292-0818 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikari K","family":"Asou","sequence":"additional","affiliation":[{"name":"Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute , 2-6-7 Kazusa Kamatari, Kisarazu, Chiba 292-0818 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute , 2-6-7 Kazusa Kamatari, Kisarazu, Chiba 292-0818 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3328-9571","authenticated-orcid":false,"given":"Osamu","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Applied Genomics, Kazusa DNA Research Institute , 2-6-7 Kazusa Kamatari, Kisarazu, Chiba 292-0818 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinori","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine, Chiba University , 1-8-1 Inohana. Chuo-ku, Chiba 260-8670 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoko Y","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology, Graduate School of Medicine, Chiba University , 1-8-1 Inohana. Chuo-ku, Chiba 260-8670 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-1938","authenticated-orcid":false,"given":"Yusuke","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute , 2-6-7 Kazusa Kamatari, Kisarazu, Chiba 292-0818 , Japan"},{"name":"Department of Omics Medicine, Graduate School of Medicine, Chiba University , 1-8-1 Inohana. 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