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Regarding these cells, the unique modes of thymic selection and maturation elucidate innateness, irrespective of them also being members of the adaptive immune system as a T-cell. iNKT cells develop and differentiate into NKT1 [interferon \u03b3 (IFN-\u03b3)-producing], NKT2 [interleukin 4 (IL-4)\/IL-13-producing], or NKT17 (IL-17-producing) subsets in the thymus. After egress, NKT10 (IL-10-producing), follicular helper NKT (NKTfh; IL-21-producing), and regulatory NKT (NKTreg) subsets emerge following stimulation in the periphery. Moreover, iNKT cells have been shown to possess several physiological or pathological roles. iNKT cells exhibit dual alleviating or aggravating roles in experimentally induced immune and\/or inflammatory diseases in mice. These findings indicate that the modulation of iNKT cells can be employed for therapeutic use or prevention of human diseases. In this review, we discuss the potential roles of iNKT cells in the development of immune\/inflammatory diseases of the cardiovascular system, with emphasis on atherosclerosis, aortic aneurysms, and cardiac remodeling.<\/jats:p>","DOI":"10.1093\/intimm\/dxae019","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T13:38:10Z","timestamp":1711978690000},"page":"377-392","source":"Crossref","is-referenced-by-count":12,"title":["Recent advances regarding the potential roles of invariant natural killer T cells in cardiovascular diseases with immunological and inflammatory backgrounds"],"prefix":"10.1093","volume":"36","author":[{"given":"Kazuya","family":"Iwabuchi","sequence":"first","affiliation":[{"name":"Kitasato University , Tokyo 108-8641 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Immunology, Kitasato University School of Medicine , Sagamihara 252-0374 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kitasato University School of Medicine , Sagamihara 252-0374 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Ishimori","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University , Sapporo 060-0638 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"2024071313362866800_CIT0001","first-page":"535","article-title":"Mouse CD1-specific NK1 T cells: development, specificity, and function","volume-title":"Annu Rev Immunol","author":"Bendelac","year":"1997"},{"key":"2024071313362866800_CIT0002","first-page":"231","article-title":"NKT cells: what\u2019s in a name","volume-title":"Nat Rev 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