{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:18:32Z","timestamp":1764656312506,"version":"3.37.3"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Oita University President\u2019s Strategic Discretionary Fund"},{"name":"Grant for Joint Research Project of the Research Institute for Microbial Diseases, Osaka University"},{"name":"Four Seasons Ladies Clinic Research Grant"},{"name":"The Nakatomi Foundation"},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K18482","24K12629","20K16499","20K16028","21K07984"],"award-info":[{"award-number":["20K18482","24K12629","20K16499","20K16028","21K07984"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Toxoplasma gondii (T. gondii) is a zoonotic protozoan parasite that causes congenital toxoplasmosis, including fetal death, abortion, stillbirth, morphological abnormalities, and premature birth. Primary T. gondii infection in pregnant women results in congenital toxoplasmosis. C\u2013C chemokine receptor (CCR) 2 is reportedly a critical host defense factor against T. gondii infection. However, details of the role of CCR2 in the host immune response to T. gondii in congenital toxoplasmosis remain unclear. Here, we infected pregnant CCR2-deficient mice with T. gondii, resulting in stillbirth, embryonic resorption, fetal morphological abnormalities, and preterm delivery at significantly higher rates than those in pregnant wild-type (WT) mice. Consistent with the severity of abnormal pregnancy, a large area of placental hemorrhage and a large number of T. gondii infections around the hemorrhagic area were observed in the placentas of CCR2-deficient mice. In addition, the accumulation of inflammatory monocytes in the placenta was reduced in CCR2-deficient mice during infection. We further confirmed that the adoptive transfer of inflammatory monocytes collected from WT mice into T. gondii-infected pregnant CCR2-deficient mice effectively suppressed placental damage and abnormal pregnancy. Collectively, CCR2 contributes to pregnancy maintenance by regulating the migration of inflammatory monocytes into the placenta of T. gondii-infected pregnant mice.<\/jats:p>","DOI":"10.1093\/intimm\/dxae046","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T12:20:35Z","timestamp":1721910035000},"page":"39-52","source":"Crossref","is-referenced-by-count":1,"title":["CCR2-dependent placental migration of inflammatory monocytes suppresses abnormal pregnancies caused by <i>Toxoplasma gondii<\/i> infection"],"prefix":"10.1093","volume":"37","author":[{"given":"Naganori","family":"Kamiyama","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Control, Faculty of Medicine, Oita University , Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Faculty of Medicine, Oita University , Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuma","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Faculty of Medicine, Oita University , Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanyakorn","family":"Chalalai","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Faculty of Medicine, Oita University , Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Sachi","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Faculty of Medicine, Oita University , Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sotaro","family":"Ozaka","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Faculty of Medicine, Oita University , Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Soga","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Faculty of Medicine, Oita University , Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yomei","family":"Kagoshima","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Faculty of Medicine, Oita University , Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supanuch","family":"Ekronarongchai","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Faculty of Medicine, Oita University , Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University , Suita, Osaka 565-0871 ,","place":["Japan"]},{"name":"Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University , Suita, Osaka 565-0871 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University , Suita, Osaka 565-0871 ,","place":["Japan"]},{"name":"Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University , Suita, Osaka 565-0871 ,","place":["Japan"]},{"name":"Department of Immunoparasitology, Center for Infectious Disease Education and Research, Osaka University , Suita, Osaka 565-0871 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Faculty of Medicine, Oita University , Oita 879-5593 ,","place":["Japan"]},{"name":"Research Center for GLOBAL and LOCAL Infectious Diseases, Oita University , Oita 879-5593 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"2025010817063753500_CIT0001","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.ijpara.2009.02.003","article-title":"Toxoplasma gondii: 25 years and 25 major advances for the field","volume":"39","author":"Boothroyd","year":"2009","journal-title":"Int J 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