{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:35:14Z","timestamp":1791725714367,"version":"4.3.4"},"reference-count":120,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Fondation Recherche Medicale","award":["Equipes-FRM 2018"],"award-info":[{"award-number":["Equipes-FRM 2018"]}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["ANR-10-IDEX-0002"],"award-info":[{"award-number":["ANR-10-IDEX-0002"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Atopic diseases, including atopic dermatitis (AD), food allergy (FA), asthma, and allergic rhinitis (AR) are closely related to inflammatory diseases involving different body sites (i.e. the skin, airway, and digestive tract) with characteristic features including specific IgE to allergens (so-called \u201catopy\u201d) and Th2 cell-mediated inflammation. It has been recognized that AD often precedes the development of other atopic diseases. The progression from AD during infancy to FA or asthma\/AR in later childhood is referred to as the \u201catopic march\u201d (AM). Clinical, genetic, and experimental studies have provided evidence that allergen sensitization occurring through AD skin could be the origin of the AM. Here, we provide an updated review focusing on the role of the skin in the AM, from genetic mutations and environmental factors associated with epidermal barrier dysfunction in AD and the AM to immunological mechanisms for skin sensitization, particularly recent progress on the function of key cytokines produced by epidermal keratinocytes or by immune cells infiltrating the skin during AD. We also highlight the importance of developing strategies that target AD skin to prevent and attenuate the AM.<\/jats:p>","DOI":"10.1093\/intimm\/dxae053","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:26:56Z","timestamp":1726187216000},"page":"567-577","source":"Crossref","is-referenced-by-count":10,"title":["The role of the skin in the atopic march"],"prefix":"10.1093","volume":"36","author":[{"given":"Xin","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Functional Genomics and Cancer, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), CNRS UMR 7104, Inserm U 1258, Universit\u00e9 de Strasbourg , Illkirch 67404 ,","place":["France"]},{"name":"Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University , Chongqing 40000 ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4225-6699","authenticated-orcid":false,"given":"Mei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Functional Genomics and Cancer, Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), CNRS UMR 7104, Inserm U 1258, Universit\u00e9 de Strasbourg , Illkirch 67404 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"2024102602012742400_CIT0001","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1016\/j.jaci.2003.09.033","article-title":"Atopic dermatitis and the atopic march","volume":"112","author":"Spergel","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"2024102602012742400_CIT0002","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.anai.2017.10.037","article-title":"The atopic march: critical evidence and clinical relevance","volume":"120","author":"Hill","year":"2018","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2024102602012742400_CIT0003","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jaci.2015.10.049","article-title":"Does atopic dermatitis cause food allergy? 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