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In contrast, our group has previously shown that levels of circulating CD26+ T cells are decreased in patients with systemic lupus erythematosus (SLE), although the role of reduced CD26 T cell surface expression in SLE pathology remains to be elucidated. In the present study, we conducted CD26-based T cell subset analyses utilizing peripheral blood mononuclear cells from 57 SLE patients and 31 healthy adult volunteers. We show that the increase in the CD26(\u2212) T cell population reflects the abnormal expansion of CD26(\u2212)CD28(\u2212) cytotoxic subsets of both CD8 T cells and CD4 T cells in SLE patients. Single-cell RNA sequencing analysis of the CD26(\u2212)CD28(\u2212) CD4 and CD8 T cell populations reveals unique characteristics with similarities to natural killer T cells. In addition, the level of CD26(\u2212)CD28(\u2212) T cells is increased in some active-stage SLE patients with renal manifestation. Meanwhile, the effect of prednisolone treatment on these populations varies from patient to patient, with levels of these cytotoxic effector populations still being elevated in some inactive-stage SLE patients. Taken together, our data suggest that analysis of these populations in SLE may be a useful tool to classify this markedly heterogeneous condition.<\/jats:p>","DOI":"10.1093\/intimm\/dxae062","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T23:19:55Z","timestamp":1728343195000},"page":"153-172","source":"Crossref","is-referenced-by-count":3,"title":["An abnormal increase in CD26(\u2212)CD28(\u2212) cytotoxic effector CD4 and CD8 T cell populations in patients with systemic lupus erythematosus"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-7275","authenticated-orcid":false,"given":"Ryo","family":"Hatano","sequence":"first","affiliation":[{"name":"Department of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University , Bunkyo-ku, Tokyo 113-8421 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