{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T13:40:01Z","timestamp":1751290801557,"version":"3.41.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K06868"],"award-info":[{"award-number":["JP21K06868"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Monocytes recruited to inflamed tissues differentiate into macrophages, contributing to the resolution of inflammation and tissue repair. However, the mechanisms underlying the development, differentiation, and maturation of these monocyte-derived macrophages (MOMs) remain incompletely understood. Here, we demonstrate that TGF\u03b2-activated kinase 1 (TAK1), a key signaling mediator downstream of various receptors including cytokine receptors and Toll-like receptors, is essential for MOM development. In a zymosan-induced model of acute sterile peritonitis, mice with myeloid-specific deletion of TAK1 exhibited a severe impairment in MOM development within the peritoneal cavity, in contrast to control mice. Blocking death-receptor signaling with neutralizing-antibodies facilitated the recovery of MOM development in these mice, albeit to a limited extent. We identified a transient population of immediate macrophage precursors differentiating from infiltrating monocytes in the peritoneal cavity. Notably, TAK1-deficient macrophage precursors displayed marked susceptibility to cell death, possibly due to a previously unrecognized mechanism distinct from well-characterized cell death pathways. These findings establish TAK1 as a critical regulator of MOM development and uncover a novel survival mechanism in the macrophage precursors during inflammation.<\/jats:p>","DOI":"10.1093\/intimm\/dxaf019","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T07:05:58Z","timestamp":1743318358000},"page":"417-429","source":"Crossref","is-referenced-by-count":0,"title":["TAK1 governs monocyte-derived macrophage development in acute sterile peritonitis"],"prefix":"10.1093","volume":"37","author":[{"given":"Katsuki","family":"Iwahori","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Immunology, Shinshu University School of Medicine , 3-1-1, Asahi, Matsumoto, Nagano 390-8621 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Immunology, Shinshu University School of Medicine , 3-1-1, Asahi, Matsumoto, Nagano 390-8621 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1953-8145","authenticated-orcid":false,"given":"Hideki","family":"Sanjo","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Immunology, Shinshu University School of Medicine , 3-1-1, Asahi, Matsumoto, Nagano 390-8621 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,3,29]]},"reference":[{"key":"2025063009011358800_CIT0001","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.immuni.2016.02.024","article-title":"Tissue-resident macrophage ontogeny and homeostasis","volume":"44","author":"Ginhoux","year":"2016","journal-title":"Immunity"},{"key":"2025063009011358800_CIT0002","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/s41586-023-06002-x","article-title":"Physiology and diseases of tissue-resident macrophages","volume":"618","author":"Lazarov","year":"2023","journal-title":"Nature"},{"key":"2025063009011358800_CIT0003","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.immuni.2013.04.004","article-title":"Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes","volume":"38","author":"Hashimoto","year":"2013","journal-title":"Immunity"},{"key":"2025063009011358800_CIT0004","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1182\/blood-2013-01-478206","article-title":"Local apoptosis mediates clearance of macrophages from resolving inflammation in mice","volume":"122","author":"Gautier","year":"2013","journal-title":"Blood"},{"key":"2025063009011358800_CIT0005","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.immuni.2014.12.020","article-title":"Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection","volume":"42","author":"Bleriot","year":"2015","journal-title":"Immunity"},{"key":"2025063009011358800_CIT0006","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1172\/JCI124615","article-title":"The role of macrophages in the resolution of inflammation","volume":"129","author":"Watanabe","year":"2019","journal-title":"J Clin Invest"},{"key":"2025063009011358800_CIT0007","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1152\/physrev.00002.2021","article-title":"The evolution of regulated cell death pathways in animals and their evasion by pathogens","volume":"102","author":"Tummers","year":"2022","journal-title":"Physiol Rev"},{"key":"2025063009011358800_CIT0008","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1126\/science.aau2818","article-title":"Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death","volume":"362","author":"Orning","year":"2018","journal-title":"Science"},{"key":"2025063009011358800_CIT0009","doi-asserted-by":"publisher","first-page":"E10888","DOI":"10.1073\/pnas.1809548115","article-title":"Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection","volume":"115","author":"Sarhan","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025063009011358800_CIT0010","doi-asserted-by":"publisher","first-page":"e101638","DOI":"10.15252\/embj.2019101638","article-title":"Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly","volume":"38","author":"Chen","year":"2019","journal-title":"EMBO J"},{"key":"2025063009011358800_CIT0011","doi-asserted-by":"publisher","first-page":"783","DOI":"10.4049\/jimmunol.1900202","article-title":"Cutting Edge: TAK1 safeguards macrophages against proinflammatory cell death","volume":"203","author":"Sanjo","year":"2019","journal-title":"J Immunol"},{"key":"2025063009011358800_CIT0012","doi-asserted-by":"publisher","first-page":"jem.20191644","DOI":"10.1084\/jem.20191644","article-title":"Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease","volume":"217","author":"Malireddi","year":"2020","journal-title":"J Exp Med"},{"key":"2025063009011358800_CIT0013","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.4049\/jimmunol.2200322","article-title":"TAK1 limits death receptor fas-induced proinflammatory cell death in macrophages","volume":"209","author":"Maeda","year":"2022","journal-title":"J Immunol"},{"key":"2025063009011358800_CIT0014","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1038\/ni1255","article-title":"Essential function for the kinase TAK1 in innate and adaptive immune responses","volume":"6","author":"Sato","year":"2005","journal-title":"Nat Immunol"},{"key":"2025063009011358800_CIT0015","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1073\/pnas.0915000107","article-title":"Two physically, functionally, and developmentally distinct peritoneal macrophage subsets","volume":"107","author":"Ghosn","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025063009011358800_CIT0016","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/s0140-6736(63)92808-3","article-title":"Reaction to antigens in vivo of the peritoneal macrophages of guinea-pigs with delayed type hypersensitivity. Effects of anticoagulants and other drugs","volume":"2","author":"Nelson","year":"1963","journal-title":"Lancet"},{"key":"2025063009011358800_CIT0017","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/jlb.57.3.361","article-title":"Review of the macrophage disappearance reaction","volume":"57","author":"Barth","year":"1995","journal-title":"J Leukoc Biol"},{"key":"2025063009011358800_CIT0018","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.cellimm.2018.01.003","article-title":"The biology of serous cavity macrophages","volume":"330","author":"Bain","year":"2018","journal-title":"Cell Immunol"},{"key":"2025063009011358800_CIT0019","doi-asserted-by":"publisher","first-page":"e2206617","DOI":"10.1002\/advs.202206617","article-title":"Mouse tissue-resident peritoneal macrophages in homeostasis, repair, infection, and tumor metastasis","volume":"10","author":"Ardavin","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"2025063009011358800_CIT0020","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.it.2022.12.002","article-title":"Gata6(+) large peritoneal macrophages: an evolutionarily conserved sentinel and effector system for infection and injury","volume":"44","author":"Salm","year":"2023","journal-title":"Trends Immunol"},{"key":"2025063009011358800_CIT0021","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/s1357-2725(03)00242-5","article-title":"The mesothelial cell","volume":"36","author":"Mutsaers","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"2025063009011358800_CIT0022","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/imr.12536","article-title":"RIPK3 in cell death and inflammation: the good, the bad, and the ugly","volume":"277","author":"Orozco","year":"2017","journal-title":"Immunol Rev"},{"key":"2025063009011358800_CIT0023","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/imr.12541","article-title":"Caspase-8: regulating life and death","volume":"277","author":"Tummers","year":"2017","journal-title":"Immunol Rev"},{"key":"2025063009011358800_CIT0024","doi-asserted-by":"publisher","first-page":"a036368","DOI":"10.1101\/cshperspect.a036368","article-title":"Multitasking kinase RIPK1 regulates cell death and inflammation","volume":"12","author":"Newton","year":"2020","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2025063009011358800_CIT0025","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.cell.2009.05.021","article-title":"Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha","volume":"137","author":"He","year":"2009","journal-title":"Cell"},{"key":"2025063009011358800_CIT0026","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1126\/science.1172308","article-title":"RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis","volume":"325","author":"Zhang","year":"2009","journal-title":"Science"},{"key":"2025063009011358800_CIT0027","doi-asserted-by":"publisher","first-page":"14329","DOI":"10.1038\/ncomms14329","article-title":"RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat Commun"},{"key":"2025063009011358800_CIT0028","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1182\/blood.2021011798","article-title":"Heightened turnover and failed maturation of monocyte-derived macrophages in murine chronic granulomatous disease","volume":"139","author":"Gibbings","year":"2022","journal-title":"Blood"},{"key":"2025063009011358800_CIT0029","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1182\/blood.V77.4.673.673","article-title":"Molecular basis of chronic granulomatous disease","volume":"77","author":"Smith","year":"1991","journal-title":"Blood"},{"key":"2025063009011358800_CIT0030","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1146\/annurev-immunol-042617-053010","article-title":"Apoptosis and clearance of apoptotic cells","volume":"36","author":"Nagata","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"2025063009011358800_CIT0031","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.it.2023.10.004","article-title":"Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis","volume":"44","author":"Rodriguez-Morales","year":"2023","journal-title":"Trends Immunol"},{"key":"2025063009011358800_CIT0032","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"key":"2025063009011358800_CIT0033","doi-asserted-by":"publisher","first-page":"707856","DOI":"10.3389\/fimmu.2021.707856","article-title":"The role of macrophages during mammalian tissue remodeling and regeneration under infectious and non-infectious conditions","volume":"12","author":"Bohaud","year":"2021","journal-title":"Front Immunol"},{"key":"2025063009011358800_CIT0034","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.immuni.2019.05.010","article-title":"A stromal niche defined by expression of the transcription factor WT1 mediates programming and homeostasis of cavity-resident macrophages","volume":"51","author":"Buechler","year":"2019","journal-title":"Immunity"},{"key":"2025063009011358800_CIT0035","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1002\/eji.201948164","article-title":"Mesothelial cell CSF1 sustains peritoneal macrophage proliferation","volume":"49","author":"Ivanov","year":"2019","journal-title":"Eur J Immunol"},{"key":"2025063009011358800_CIT0036","doi-asserted-by":"publisher","first-page":"742","DOI":"10.4049\/jimmunol.2200278","article-title":"Mesothelium-derived factors shape GATA6-positive large cavity macrophages","volume":"209","author":"Lai","year":"2022","journal-title":"J Immunol"},{"key":"2025063009011358800_CIT0037","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.molmed.2004.09.003","article-title":"Nrf2-Keap1 defines a physiologically important stress response mechanism","volume":"10","author":"Motohashi","year":"2004","journal-title":"Trends Mol Med"},{"key":"2025063009011358800_CIT0038","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1089\/ars.2016.6663","article-title":"TAK1 Regulates the Nrf2 antioxidant system through modulating p62\/SQSTM1","volume":"25","author":"Hashimoto","year":"2016","journal-title":"Antioxid Redox Signal"},{"key":"2025063009011358800_CIT0039","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol"},{"key":"2025063009011358800_CIT0040","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41590-017-0013-y","article-title":"Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway","volume":"19","author":"Holze","year":"2018","journal-title":"Nat Immunol"},{"key":"2025063009011358800_CIT0041","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41556-023-01091-2","article-title":"Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis","volume":"25","author":"Liu","year":"2023","journal-title":"Nat Cell Biol"}],"container-title":["International Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/intimm\/advance-article-pdf\/doi\/10.1093\/intimm\/dxaf019\/62808573\/dxaf019.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/intimm\/article-pdf\/37\/7\/417\/62808573\/dxaf019.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/intimm\/article-pdf\/37\/7\/417\/62808573\/dxaf019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T13:01:18Z","timestamp":1751288478000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/intimm\/article\/37\/7\/417\/8100186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,29]]},"references-count":41,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,3,29]]},"published-print":{"date-parts":[[2025,6,17]]}},"URL":"https:\/\/doi.org\/10.1093\/intimm\/dxaf019","relation":{},"ISSN":["1460-2377"],"issn-type":[{"type":"electronic","value":"1460-2377"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,3,29]]}}}