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We investigated Breg subsets in non-infectious uveitis (NIU) and in mouse models of experimental autoimmune uveitis (EAU). Blood samples from NIU patients with active disease (n = 13), in remission (n = 37) and healthy controls (n = 10) were immunophenotyped for CD19+CD24hiCD38lo memory B cells, CD19+CD24hiCD38hi-immature Bregs (iBregs), and CD19+CD38intCD24int-mature Bregs. In NIU, levels of peripheral blood iBregs and serum interleukin-10 (IL-10) were decreased in active disease vs. remission (P &amp;lt; .01). In quiescent NIU, iBregs were isolated and, when added at increasing ratios to autologous CD3+ T cells, downregulated T-cell proliferation. In an EAU model, at peak disease, CD19+CD1dhiCD5+ B10, CD19+CD5+ B1, CD19+CD21hiCD24hiCD23+ transitional two marginal-zone precursor (T2-MZP) and CD19+CD21hiCD23\u2212 marginal-zone B (MZB) Breg subsets were analysed both phenotypically and functionally. In EAU spleens, all Breg subsets investigated were detectable, but the IL-10\u2013expressing B10-Breg subset was immunosuppressive and inversely correlated with disease severity (P = .048, R2 = 0.47). Blood-derived IL-10\u2013expressing B10 and B1 Bregs were increased in both adjuvant controls and EAU but were significantly reduced in clinically milder EAU. In dissociated retinal cells, only the B10-Breg subset was detectable and increased in EAU. Selective Breg subsets may be immunosuppressive, with iBregs in NIU and IL-10\u2013expressing B10 Bregs in EAU.<\/jats:p>","DOI":"10.1093\/intimm\/dxag021","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T11:43:45Z","timestamp":1778067825000},"page":"569-580","source":"Crossref","is-referenced-by-count":0,"title":["Selective decreases in regulatory B-cell (Breg) subsets in active uveitis: IL-10+CD19+CD24hiCD38hiBregs in patients and B10 Bregs in mice"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-939X","authenticated-orcid":false,"given":"Yi-Hsing","family":"Chen","sequence":"first","affiliation":[{"name":"UCL Institute of Ophthalmology, Bath Street , London EC1V 9EL ,","place":["UK"]},{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital , Taoyuan, 33305 ,","place":["Taiwan"]},{"name":"College of Medicine, Chang Gung University , Taoyuan 333 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