{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:00:59Z","timestamp":1784736059197,"version":"3.55.0"},"reference-count":89,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["22K07134"],"award-info":[{"award-number":["22K07134"]}]},{"name":"Japan Society for the Promotion of Science (JSPS) KAKENHI","award":["25K02484"],"award-info":[{"award-number":["25K02484"]}]},{"DOI":"10.13039\/501100005927","name":"Daiichi Sankyo Foundation of Life Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005927","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004330","name":"Smoking Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Respiratory infections remain a major threat to global health. To counter these insults, the respiratory system has evolved multilayered defense strategies that integrate anatomical and mechanical barriers with both innate and adaptive immune responses. Mucociliary clearance (MCC) serves as a cornerstone of airway host defense, whereby coordinated ciliary beating at the luminal surface of the airway epithelium drives the efficient removal of inhaled particles and pathogens. This process provides robust, broad-spectrum protection against both routine environmental exposures and emerging respiratory pathogens. In this review, we summarize the current understanding of respiratory barrier function and defense strategies, with a particular emphasis on the immunological and metabolic mechanisms that regulate MCC. We further highlight the role of aldehyde dehydrogenases in preventing ciliary damage and preserving MCC function, thereby conferring protection against environmental stress and respiratory infections.<\/jats:p>","DOI":"10.1093\/intimm\/dxag034","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:39:44Z","timestamp":1783424384000},"source":"Crossref","is-referenced-by-count":0,"title":["Control of mucociliary clearance in airway host defense"],"prefix":"10.1093","author":[{"given":"Noriko","family":"Shinjyo","sequence":"first","affiliation":[{"name":"Laboratory of Homeostatic Physiology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, Kobe 650-0017 ,","place":["Japan"]},{"name":"Department of Molecular Biology, Research Institute for Microbial Diseases, The University of Osaka, Osaka 565-0871 ,","place":["Japan"]},{"name":"School of Tropical Medicine and Global Health, Nagasaki University , Nagasaki 852-8523 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Shigemura","sequence":"additional","affiliation":[{"name":"Laboratory of Homeostatic Physiology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, Kobe 650-0017 ,","place":["Japan"]},{"name":"Division of Thoracic Surgery, Feinberg School of Medicine, Northwestern University , Chicago, IL 60611 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Okabe","sequence":"additional","affiliation":[{"name":"Laboratory of Homeostatic Physiology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, Kobe 650-0017 ,","place":["Japan"]},{"name":"World Premier International Research Center, Immunology Frontier Research Center (IFReC), The University of Osaka , Osaka 565-0871 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