{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:01:04Z","timestamp":1785268864242,"version":"3.55.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJFR206D"],"award-info":[{"award-number":["JPMJFR206D"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJMS2025"],"award-info":[{"award-number":["JPMJMS2025"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Agency for Medical Research and Development","award":["JP20fk0108137"],"award-info":[{"award-number":["JP20fk0108137"]}]},{"name":"Agency for Medical Research and Development","award":["JP23fk0108682"],"award-info":[{"award-number":["JP23fk0108682"]}]},{"name":"Agency for Medical Research and Development","award":["JP223fa627002"],"award-info":[{"award-number":["JP223fa627002"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K10257"],"award-info":[{"award-number":["24K10257"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K23873"],"award-info":[{"award-number":["25K23873"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Usage and Joint Research Programs of the Institute of Advanced Medical Sciences"},{"DOI":"10.13039\/501100005623","name":"Tokushima University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005623","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mochida Memorial Foundation"},{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100024224","name":"Chemo-Sero-Therapeutic Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019670","name":"Research Foundation for Microbial Diseases of Osaka University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019670","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BIKEN Taniguchi Scholarship"},{"name":"The Nippon Foundation\u2013Osaka University Project for Infectious Disease Prevention"},{"name":"Joint Research Program of Research Center for Global and Local Infectious Diseases of Oita University","award":["2024B08"],"award-info":[{"award-number":["2024B08"]}]},{"DOI":"10.13039\/501100005927","name":"Daiichi Sankyo Foundation of Life Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005927","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Osaka Cancer Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Regulatory T cells (Tregs) play an essential role in maintaining immune tolerance and controlling excessive inflammation. Although traditionally viewed as a stable lineage dedicated to broad immunosuppression, accumulating evidence has revealed that Tregs exhibit remarkable heterogeneity and functional adaptability, allowing them to undergo specialization in response to local inflammatory environments. Among these specialized subsets, Th1-type Tregs (Th1-Tregs), characterized by the co-expression of Foxp3 and the transcription factor T-bet, have emerged as key regulators of type 1 immune responses. By expressing the chemokine receptor CXCR3, these cells localize to IFN-\u03b3\u2013rich inflammatory sites and selectively modulate Th1-driven immune circuits. Recent studies have demonstrated that Th1-Tregs play context-dependent roles across diverse pathological conditions. In the tumor microenvironment, they suppress cytotoxic immunity and contribute to tumor immune evasion. In contrast, during autoimmune diseases and acute infections, Th1-adapted regulatory programs protect host tissues by restraining excessive inflammation. These findings highlight how Tregs dynamically adapt to local inflammatory environments to control type 1 immune responses in different tissues. In this review, we summarize the molecular mechanisms underlying Th1-Treg differentiation and discuss how these specialized regulatory programs shape immune responses across different disease contexts.<\/jats:p>","DOI":"10.1093\/intimm\/dxag038","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T11:52:35Z","timestamp":1783770755000},"source":"Crossref","is-referenced-by-count":0,"title":["Th1-adapted regulatory T cells in tumor immunity and inflammatory diseases"],"prefix":"10.1093","author":[{"given":"Ayumi","family":"Kuratani","sequence":"first","affiliation":[{"name":"Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University , Suita, Osaka 565-0871 ,","place":["Japan"]},{"name":"Laboratory of Immunoparasitology, World Premier International Immunology Frontier Research Center, Osaka University , Suita, Osaka 565-0871 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Faculty of Medicine, Oita University , Oita 879-5593 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Control, Faculty of Medicine, Oita University , Oita 879-5593 ,","place":["Japan"]},{"name":"Division of Pathophysiology, Research Center for GLOBAL and LOCAL Infectious Diseases, Oita University , Oita 879-5593 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University , Suita, Osaka 565-0871 ,","place":["Japan"]},{"name":"Laboratory of Immunoparasitology, World Premier International Immunology Frontier Research Center, Osaka University , Suita, Osaka 565-0871 ,","place":["Japan"]},{"name":"Department of Immunoparasitology, Center for Infectious Disease Education and Research, Osaka University , Suita, Osaka 565-0871 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"2026072815153952600_dxag038-B1","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T cells and immune tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell"},{"key":"2026072815153952600_dxag038-B2","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat Immunol"},{"key":"2026072815153952600_dxag038-B3","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nri3464","article-title":"The plasticity and stability of regulatory T cells","volume":"13","author":"Sakaguchi","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"2026072815153952600_dxag038-B4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/imr.12175","article-title":"Lineage stability and phenotypic plasticity of Foxp3+ regulatory T cells","volume":"259","author":"Hori","year":"2014","journal-title":"Immunol Rev"},{"key":"2026072815153952600_dxag038-B5","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.3389\/fimmu.2019.02716","article-title":"Metabolic control of Treg cell stability, plasticity, and tissue-specific heterogeneity","volume":"10","author":"Shi","year":"2019","journal-title":"Front Immunol"},{"key":"2026072815153952600_dxag038-B6","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/ni.3053","article-title":"Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance","volume":"16","author":"Yu","year":"2015","journal-title":"Nat Immunol"},{"key":"2026072815153952600_dxag038-B7","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/ni.1731","article-title":"The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation","volume":"10","author":"Koch","year":"2009","journal-title":"Nat Immunol"},{"key":"2026072815153952600_dxag038-B8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/nature07674","article-title":"Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses","volume":"458","author":"Zheng","year":"2009","journal-title":"Nature"},{"key":"2026072815153952600_dxag038-B9","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1126\/science.1172702","article-title":"CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner","volume":"326","author":"Chaudhry","year":"2009","journal-title":"Science"},{"key":"2026072815153952600_dxag038-B10","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1126\/science.aac4263","article-title":"The microbiota regulates type 2 immunity through ROR\u03b3t+ T cells","volume":"349","author":"Ohnmacht","year":"2015","journal-title":"Science"},{"key":"2026072815153952600_dxag038-B11","doi-asserted-by":"publisher","first-page":"4503","DOI":"10.1172\/JCI57456","article-title":"GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice","volume":"121","author":"Wohlfert","year":"2011","journal-title":"J Clin Invest"},{"key":"2026072815153952600_dxag038-B12","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/nm.2426","article-title":"Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions","volume":"17","author":"Chung","year":"2011","journal-title":"Nat Med"},{"key":"2026072815153952600_dxag038-B13","doi-asserted-by":"publisher","first-page":"4351","DOI":"10.1158\/0008-5472.CAN-12-0579","article-title":"CXCR3+ T regulatory cells selectively accumulate in human ovarian carcinomas to limit type I immunity","volume":"72","author":"Redjimi","year":"2012","journal-title":"Cancer Res"},{"key":"2026072815153952600_dxag038-B14","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nature22360","article-title":"Stability and function of regulatory T cells expressing the transcription factor T-bet","volume":"546","author":"Levine","year":"2017","journal-title":"Nature"},{"key":"2026072815153952600_dxag038-B15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2051-1426-2-3","article-title":"Mechanism of tumor rejection with doublets of CTLA-4, PD-1\/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment","volume":"2","author":"Spranger","year":"2014","journal-title":"J Immunother Cancer"},{"key":"2026072815153952600_dxag038-B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112813","article-title":"A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity","volume":"42","author":"Okamoto","year":"2023","journal-title":"Cell Rep"},{"key":"2026072815153952600_dxag038-B17","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1016\/j.immuni.2023.06.003","article-title":"CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8+ T cell antitumor immunity","volume":"56","author":"Moreno Ayala","year":"2023","journal-title":"Immunity"},{"key":"2026072815153952600_dxag038-B18","doi-asserted-by":"publisher","DOI":"10.1126\/science.adn8608","article-title":"Platelet factor 4-induced TH1-Treg polarization suppresses antitumor immunity","volume":"386","author":"Kuratani","year":"2024","journal-title":"Science"},{"key":"2026072815153952600_dxag038-B19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2401692121","article-title":"IFN-\u03b3-induced Th1-Treg polarization in inflamed brains limits exacerbation of experimental autoimmune encephalomyelitis","volume":"121","author":"Okamoto","year":"2024","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026072815153952600_dxag038-B20","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.immuni.2012.05.031","article-title":"T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor \u03b22","volume":"37","author":"Koch","year":"2012","journal-title":"Immunity"},{"key":"2026072815153952600_dxag038-B21","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1084\/jem.20061852","article-title":"Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease","volume":"204","author":"Lahl","year":"2007","journal-title":"J Exp Med"},{"key":"2026072815153952600_dxag038-B22","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/j.1600-065X.2011.01018.x","article-title":"Regulatory T cells and Foxp3","volume":"241","author":"Rudensky","year":"2011","journal-title":"Immunol Rev"},{"key":"2026072815153952600_dxag038-B23","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3389\/fimmu.2015.00069","article-title":"T-bet expression by Foxp3(+) T regulatory cells is not essential for their suppressive function in CNS autoimmune disease or colitis","volume":"6","author":"McPherson","year":"2015","journal-title":"Front Immunol"},{"key":"2026072815153952600_dxag038-B24","doi-asserted-by":"publisher","first-page":"7556","DOI":"10.1073\/pnas.95.13.7556","article-title":"Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice","volume":"95","author":"Kaplan","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026072815153952600_dxag038-B25","first-page":"3399","article-title":"A role of interferon-\u03b3 (IFN-\u03b3) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sitesin IFN-\u03b3-deficient Mice","volume":"61","author":"Nakajima","year":"2001","journal-title":"Cancer Res"},{"key":"2026072815153952600_dxag038-B26","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1126\/science.1164206","article-title":"Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity","volume":"322","author":"Hildner","year":"2008","journal-title":"Science"},{"key":"2026072815153952600_dxag038-B27","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.ccell.2017.04.003","article-title":"Tumor-residing Batf3 dendritic cells are required for effector T cell trafficking and adoptive T cell therapy","volume":"31","author":"Spranger","year":"2017","journal-title":"Cancer Cell"},{"key":"2026072815153952600_dxag038-B28","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1053\/j.gastro.2011.03.009","article-title":"Interleukin-12 converts Foxp3+ regulatory T cells to interferon-\u03b3-producing Foxp3+ T cells that inhibit colitis","volume":"140","author":"Feng","year":"2011","journal-title":"Gastroenterology"},{"key":"2026072815153952600_dxag038-B29","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1084\/jem.20030152","article-title":"Conversion of peripheral CD4","volume":"198","author":"Chen","year":"2003","journal-title":"J Exp Med"},{"key":"2026072815153952600_dxag038-B30","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1111\/j.1600-6143.2004.00566.x","article-title":"TGF-beta induces Foxp3 + T-regulatory cells from CD4","volume":"4","author":"Fu","year":"2004","journal-title":"Am J Transplant"},{"key":"2026072815153952600_dxag038-B31","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20240445","article-title":"Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39","volume":"222","author":"Tan","year":"2025","journal-title":"J Exp Med"},{"key":"2026072815153952600_dxag038-B32","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.immuni.2023.06.014","article-title":"Th1-like Treg cells are dressed to suppress anti-tumor immunity","volume":"56","author":"Ramirez","year":"2023","journal-title":"Immunity"},{"key":"2026072815153952600_dxag038-B33","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s10238-025-01562-w","article-title":"Harnessing IL-27: challenges and potential in cancer immunotherapy","volume":"25","author":"Maleki","year":"2025","journal-title":"Clin Exp Med"},{"key":"2026072815153952600_dxag038-B34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1756194","article-title":"Treg-derived IFN-\u03b3 supports the differentiation of Th1-Treg in tumor immunity and autoimmunity","volume":"17","author":"Kuratani","year":"2026","journal-title":"Front Immunol"},{"key":"2026072815153952600_dxag038-B35","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nature12199","article-title":"BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis","volume":"498","author":"Roychoudhuri","year":"2013","journal-title":"Nature"},{"key":"2026072815153952600_dxag038-B36","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1126\/science.adt5661","article-title":"Macrophage modulation of tumor immunity","volume":"386","author":"Savage","year":"2024","journal-title":"Science"},{"key":"2026072815153952600_dxag038-B37","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1111\/jth.15005","article-title":"Platelet factor 4 enhances CD4+ T effector memory cell responses via Akt-PGC1\u03b1-TFAM signaling-mediated mitochondrial biogenesis","volume":"18","author":"Tan","year":"2020","journal-title":"J Thromb Haemost"},{"key":"2026072815153952600_dxag038-B38","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.yexcr.2010.12.017","article-title":"CXCR3 in T cell function","volume":"317","author":"Groom","year":"2011","journal-title":"Exp Cell Res"},{"key":"2026072815153952600_dxag038-B39","doi-asserted-by":"publisher","first-page":"a016303","DOI":"10.1101\/cshperspect.a016303","article-title":"The chemokine system in innate immunity","volume":"7","author":"Sokol","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026072815153952600_dxag038-B40","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/s41568-025-00832-9","article-title":"Regulatory T cells in the tumour microenvironment","volume":"25","author":"Imianowski","year":"2025","journal-title":"Nat Rev Cancer"},{"key":"2026072815153952600_dxag038-B41","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1456612","article-title":"The role of Foxp3 and Tbet co-expressing Treg cells in lung carcinoma","volume":"7","author":"Kachler","year":"2018","journal-title":"Oncoimmunology"},{"key":"2026072815153952600_dxag038-B42","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1277305","article-title":"Tumor-infiltrating CD39+\u03b3\u03b4Tregs are novel immunosuppressive T cells in human colorectal cancer","volume":"6","author":"Hu","year":"2017","journal-title":"Oncoimmunology"},{"key":"2026072815153952600_dxag038-B43","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.jaut.2008.04.017","article-title":"Role of Th1 and Th17 cells in organ-specific autoimmunity","volume":"31","author":"Dardalhon","year":"2008","journal-title":"J Autoimmun"},{"key":"2026072815153952600_dxag038-B44","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1111\/j.1476-5381.2011.01302.x","article-title":"Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)","volume":"164","author":"Constantinescu","year":"2011","journal-title":"Br J Pharmacol"},{"key":"2026072815153952600_dxag038-B45","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jns.2013.03.002","article-title":"Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination","volume":"333","author":"Rostami","year":"2013","journal-title":"J Neurol Sci"},{"key":"2026072815153952600_dxag038-B46","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.cellimm.2005.11.002","article-title":"Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis","volume":"237","author":"Hofstetter","year":"2005","journal-title":"Cell Immunol"},{"key":"2026072815153952600_dxag038-B47","doi-asserted-by":"publisher","first-page":"14103","DOI":"10.1073\/pnas.1616710113","article-title":"Singular role for T-BET + CXCR3+ regulatory T cells in protection from autoimmune diabetes","volume":"113","author":"Tan","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026072815153952600_dxag038-B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126311","article-title":"Th1-like ICOS+ Foxp3+ Treg cells preferentially express CXCR3 and home to \u03b2-islets during pre-diabetes in BDC2.5 NOD mice","volume":"10","author":"Kornete","year":"2015","journal-title":"PLoS One"},{"key":"2026072815153952600_dxag038-B49","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nm.2389","article-title":"Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease","volume":"17","author":"Dominguez-Villar","year":"2011","journal-title":"Nat Med"},{"key":"2026072815153952600_dxag038-B50","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.jhep.2012.07.008","article-title":"CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver","volume":"57","author":"Oo","year":"2012","journal-title":"J Hepatol"},{"key":"2026072815153952600_dxag038-B51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02158","article-title":"Tbet expression in regulatory T cells is required to initiate Th1-mediated colitis","volume":"10","author":"Di Giovangiulio","year":"2019","journal-title":"Front Immunol"},{"key":"2026072815153952600_dxag038-B52","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/mi.2010.11","article-title":"Plasticity of Treg at infected sites","volume":"3","author":"Wohlfert","year":"2010","journal-title":"Mucosal Immunol"},{"key":"2026072815153952600_dxag038-B53","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1084\/jem.20132577","article-title":"Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection","volume":"211","author":"Penaloza-MacMaster","year":"2014","journal-title":"J Exp Med"},{"key":"2026072815153952600_dxag038-B54","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1038\/s41590-023-01453-w","article-title":"IFN\u03b3-induction of TH1-like regulatory T cells controls antiviral responses","volume":"24","author":"Gocher-Demske","year":"2023","journal-title":"Nat Immunol"},{"key":"2026072815153952600_dxag038-B55","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/j.cell.2015.08.021","article-title":"A distinct function of regulatory T cells in tissue protection","volume":"162","author":"Arpaia","year":"2015","journal-title":"Cell"},{"key":"2026072815153952600_dxag038-B56","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.immuni.2012.06.014","article-title":"The cytokines interleukin 27 and interferon-\u03b3 promote distinct Treg cell populations required to limit infection-induced pathology","volume":"37","author":"Hall","year":"2012","journal-title":"Immunity"},{"key":"2026072815153952600_dxag038-B57","doi-asserted-by":"publisher","first-page":"931","DOI":"10.4049\/immunohorizons.2100080","article-title":"Tbet expression by regulatory T cells is needed to protect against Th1-mediated immunopathology during Toxoplasma infection in mice","volume":"5","author":"Warunek","year":"2021","journal-title":"Immunohorizons"},{"key":"2026072815153952600_dxag038-B58","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.immuni.2012.07.009","article-title":"A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self","volume":"37","author":"Lee","year":"2012","journal-title":"Immunity"},{"key":"2026072815153952600_dxag038-B59","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.immuni.2012.04.007","article-title":"An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes","volume":"36","author":"Darce","year":"2012","journal-title":"Immunity"},{"key":"2026072815153952600_dxag038-B60","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.immuni.2012.03.020","article-title":"Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency","volume":"36","author":"Bettini","year":"2012","journal-title":"Immunity"}],"container-title":["International Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/intimm\/advance-article-pdf\/doi\/10.1093\/intimm\/dxag038\/68769704\/dxag038.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/intimm\/advance-article-pdf\/doi\/10.1093\/intimm\/dxag038\/68769704\/dxag038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T19:15:47Z","timestamp":1785266147000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/intimm\/advance-article\/doi\/10.1093\/intimm\/dxag038\/8733812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":60,"URL":"https:\/\/doi.org\/10.1093\/intimm\/dxag038","relation":{},"ISSN":["1460-2377"],"issn-type":[{"value":"1460-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]},"article-number":"dxag038"}}