{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:45:23Z","timestamp":1791323123282,"version":"4.3.1"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,2,1]]},"DOI":"10.1093\/intimm\/dxh310","type":"journal-article","created":{"date-parts":[[2005,9,3]],"date-time":"2005-09-03T00:13:47Z","timestamp":1125706427000},"page":"221-232","source":"Crossref","is-referenced-by-count":86,"title":["WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1\u03b1"],"prefix":"10.1093","volume":"18","author":[{"given":"Maria Dolores","family":"Gallego","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"de la Fuente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines M.","family":"Anton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Snapper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fuhlbrigge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raif S.","family":"Geha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,9,1]]},"reference":[{"key":"key\n\t\t\t\t20171012150138_BIB1","doi-asserted-by":"crossref","unstructured":"Lauffenburger, D. A. and Horwitz, A. F. 1996. Cell migration: a physically integrated molecular process. Cell84:359.","DOI":"10.1016\/S0092-8674(00)81280-5"},{"key":"key\n\t\t\t\t20171012150138_BIB2","doi-asserted-by":"crossref","unstructured":"Vicente-Manzanares, M., Cabrero, J. R., Rey, M. et al. 2002. A role for the Rho-p160 Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1alpha-induced lymphocyte actomyosin and microtubular organization and chemotaxis. J. Immunol.168:400.","DOI":"10.4049\/jimmunol.168.1.400"},{"key":"key\n\t\t\t\t20171012150138_BIB3","doi-asserted-by":"crossref","unstructured":"Wei, S. H., Parker, I., Miller, M. J. and Cahalan, M. D. 2003. A stochastic view of lymphocyte motility and trafficking within the lymph node. Immunol. Rev.195:136.","DOI":"10.1034\/j.1600-065X.2003.00076.x"},{"key":"key\n\t\t\t\t20171012150138_BIB4","doi-asserted-by":"crossref","unstructured":"Campbell, D. J., Kim, C. H. and Butcher, E. C. 2003. Chemokines in the systemic organization of immunity. Immunol. Rev.195:58.","DOI":"10.1034\/j.1600-065X.2003.00067.x"},{"key":"key\n\t\t\t\t20171012150138_BIB5","doi-asserted-by":"crossref","unstructured":"Constantin, G., Majeed, M., Giagulli, C. et al.2000. Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow. Immunity13:759.","DOI":"10.1016\/S1074-7613(00)00074-1"},{"key":"key\n\t\t\t\t20171012150138_BIB6","doi-asserted-by":"crossref","unstructured":"Baggiolini, M. 1998. Chemokines and leukocyte traffic. Nature392:565.","DOI":"10.1038\/33340"},{"key":"key\n\t\t\t\t20171012150138_BIB7","doi-asserted-by":"crossref","unstructured":"Doitsidou, M., Reichman-Fried, M., Stebler, J. et al.2002. Guidance of primordial germ cell migration by the chemokine SDF-1. Cell111:647.","DOI":"10.1016\/S0092-8674(02)01135-2"},{"key":"key\n\t\t\t\t20171012150138_BIB8","doi-asserted-by":"crossref","unstructured":"Nagasawa, T., Hirota, S., Tachibana, K. et al.1996. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF\/SDF-1. Nature382:635.","DOI":"10.1038\/382635a0"},{"key":"key\n\t\t\t\t20171012150138_BIB9","doi-asserted-by":"crossref","unstructured":"Zou, Y. R., Kottmann, A. H., Kuroda, M., Taniuchi, I. and Littman, D. R. 1998. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature393:595.","DOI":"10.1038\/31269"},{"key":"key\n\t\t\t\t20171012150138_BIB10","doi-asserted-by":"crossref","unstructured":"Hattori, K., Heissig, B. and Rafii, S. 2003. The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1. Leuk. Lymphoma44:575.","DOI":"10.1080\/1042819021000037985"},{"key":"key\n\t\t\t\t20171012150138_BIB11","doi-asserted-by":"crossref","unstructured":"Bleul, C. C., Wu, L., Hoxie, J. A., Springer, T. A. and Mackay, C. R. 1997. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl Acad. Sci. USA94:1925.","DOI":"10.1073\/pnas.94.5.1925"},{"key":"key\n\t\t\t\t20171012150138_BIB12","doi-asserted-by":"crossref","unstructured":"Oberlin, E., Amara, A., Bachelerie, F. et al.1996. The CXC chemokine SDF-1 is the ligand for LESTR\/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature382:833.","DOI":"10.1038\/382833a0"},{"key":"key\n\t\t\t\t20171012150138_BIB13","doi-asserted-by":"crossref","unstructured":"Vicente-Manzanares, M., Sancho, D., Yanez-Mo, M. and Sanchez-Madrid, F. 2002. The leukocyte cytoskeleton in cell migration and immune interactions. Int. Rev. Cytol.216:233.","DOI":"10.1016\/S0074-7696(02)16007-4"},{"key":"key\n\t\t\t\t20171012150138_BIB14","doi-asserted-by":"crossref","unstructured":"Borisy, G. G. and Svitkina, T. M. 2000. Actin machinery: pushing the envelope. Curr. Opin. Cell Biol.12:104.","DOI":"10.1016\/S0955-0674(99)00063-0"},{"key":"key\n\t\t\t\t20171012150138_BIB15","doi-asserted-by":"crossref","unstructured":"Pantaloni, D., Le Clainche, C. and Carlier, M. F. 2001. Mechanism of actin-based motility. Science292:1502.","DOI":"10.1126\/science.1059975"},{"key":"key\n\t\t\t\t20171012150138_BIB16","doi-asserted-by":"crossref","unstructured":"Voermans, C., Anthony, E. C., Mul, E., van der Schoot, E. and Hordijk, P. 2001. SDF-1-induced actin polymerization and migration in human hematopoietic progenitor cells. Exp. Hematol.29:1456.","DOI":"10.1016\/S0301-472X(01)00740-8"},{"key":"key\n\t\t\t\t20171012150138_BIB17","doi-asserted-by":"crossref","unstructured":"Miletic, A. V., Swat, M., Fujikawa, K. and Swat, W. 2003. Cytoskeletal remodeling in lymphocyte activation. Curr. Opin. Immunol.15:261.","DOI":"10.1016\/S0952-7915(03)00054-2"},{"key":"key\n\t\t\t\t20171012150138_BIB18","doi-asserted-by":"crossref","unstructured":"Samstag, Y., Eibert, S. M., Klemke, M. and Wabnitz, G. H. 2003. Actin cytoskeletal dynamics in T lymphocyte activation and migration. J. Leukoc. Biol.73:30.","DOI":"10.1189\/jlb.0602272"},{"key":"key\n\t\t\t\t20171012150138_BIB19","doi-asserted-by":"crossref","unstructured":"Badour, K., Zhang, J. and Siminovitch, K. A. 2003. The Wiskott-Aldrich syndrome protein: forging the link between actin and cell activation. Immunol. Rev.192:98.","DOI":"10.1034\/j.1600-065X.2003.00031.x"},{"key":"key\n\t\t\t\t20171012150138_BIB20","doi-asserted-by":"crossref","unstructured":"Gallego, M. D., Santamaria, M., Pena, J. and Molina, I. J. 1997. Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation. Blood90:3089.","DOI":"10.1182\/blood.V90.8.3089"},{"key":"key\n\t\t\t\t20171012150138_BIB21","doi-asserted-by":"crossref","unstructured":"Snapper, S. B., Rosen, F. S., Mizoguchi, E. et al.1998. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity9:81.","DOI":"10.1016\/S1074-7613(00)80590-7"},{"key":"key\n\t\t\t\t20171012150138_BIB22","doi-asserted-by":"crossref","unstructured":"Zhang, J., Shehabeldin, A., da Cruz, L. A. et al.1999. Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J. Exp. Med.190:1329.","DOI":"10.1084\/jem.190.9.1329"},{"key":"key\n\t\t\t\t20171012150138_BIB23","doi-asserted-by":"crossref","unstructured":"Ramesh, N., Anton, I. M., Hartwig, J. H. and Geha, R. S. 1997. WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc. Natl Acad. Sci. USA94:14671.","DOI":"10.1073\/pnas.94.26.14671"},{"key":"key\n\t\t\t\t20171012150138_BIB24","doi-asserted-by":"crossref","unstructured":"Anton, I. M., Lu, W., Mayer, B. J., Ramesh, N. and Geha, R. S. 1998. The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck. J. Biol. Chem.273:20992.","DOI":"10.1074\/jbc.273.33.20992"},{"key":"key\n\t\t\t\t20171012150138_BIB25","doi-asserted-by":"crossref","unstructured":"Carlier, M. F., Ducruix, A. and Pantaloni, D. 1999. Signalling to actin: the Cdc42-N-WASP-Arp2\/3 connection. Chem. Biol.6:R235.","DOI":"10.1016\/S1074-5521(99)80107-0"},{"key":"key\n\t\t\t\t20171012150138_BIB26","doi-asserted-by":"crossref","unstructured":"Rohatgi, R., Nollau, P., Ho, H. Y., Kirschner, M. W. and Mayer, B. J. 2001. Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2\/3 pathway. J. Biol. Chem.276:26448.","DOI":"10.1074\/jbc.M103856200"},{"key":"key\n\t\t\t\t20171012150138_BIB27","doi-asserted-by":"crossref","unstructured":"Kim, A. S., Kakalis, L. T., Abdul-Manan, N., Liu, G. A. and Rosen, M. K. 2000. Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature404:151.","DOI":"10.1038\/35004513"},{"key":"key\n\t\t\t\t20171012150138_BIB28","doi-asserted-by":"crossref","unstructured":"Sasahara, Y., Rachid, R., Byrne, M. J. et al.2002. Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation. Mol. Cell10:1269.","DOI":"10.1016\/S1097-2765(02)00728-1"},{"key":"key\n\t\t\t\t20171012150138_BIB29","doi-asserted-by":"crossref","unstructured":"Anton, I. M., de la Fuente, M. A., Sims, T. N. et al.2002. WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity16:193.","DOI":"10.1016\/S1074-7613(02)00268-6"},{"key":"key\n\t\t\t\t20171012150138_BIB30","doi-asserted-by":"crossref","unstructured":"Zicha, D., Allen, W. E., Brickell, P. M. et al.1998. Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome. Br. J. Haematol.101:659.","DOI":"10.1046\/j.1365-2141.1998.00767.x"},{"key":"key\n\t\t\t\t20171012150138_BIB31","doi-asserted-by":"crossref","unstructured":"Badolato, R., Sozzani, S., Malacarne, F. et al.1998. Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenylalanine. J. Immunol.161:1026.","DOI":"10.4049\/jimmunol.161.2.1026"},{"key":"key\n\t\t\t\t20171012150138_BIB32","doi-asserted-by":"crossref","unstructured":"Haddad, E., Zugaza, J. L., Louache, F. et al.2001. The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis. Blood97:33.","DOI":"10.1182\/blood.V97.1.33"},{"key":"key\n\t\t\t\t20171012150138_BIB33","doi-asserted-by":"crossref","unstructured":"Fuhlbrigge, R. C., Alon, R., Puri, K. D., Lowe, J. B. and Springer, T. A. 1996. Sialylated, fucosylated ligands for L-selectin expressed on leukocytes mediate tethering and rolling adhesions in physiologic flow conditions. J. Cell. Biol.135:837.","DOI":"10.1083\/jcb.135.3.837"},{"key":"key\n\t\t\t\t20171012150138_BIB34","doi-asserted-by":"crossref","unstructured":"Bargatze, R. F., Kurk, S., Butcher, E. C. and Jutila, M. A. 1994. Neutrophils roll on adherent neutrophils bound to cytokine-induced endothelial cells via L-selectin on the rolling cells. J. Exp. Med.180:1785.","DOI":"10.1084\/jem.180.5.1785"},{"key":"key\n\t\t\t\t20171012150138_BIB35","unstructured":"Kitayama, J., Fuhlbrigge, R. C., Puri, K. D. and Springer, T. A. 1997. P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. J. Immunol.159:3929."},{"key":"key\n\t\t\t\t20171012150138_BIB36","doi-asserted-by":"crossref","unstructured":"Jutila, M. A., Bargatze, R. F., Kurk, S. et al.1994. Cell surface P- and E-selectin support shear-dependent rolling of bovine gamma\/delta T cells. J. Immunol.153:3917.","DOI":"10.4049\/jimmunol.153.9.3917"},{"key":"key\n\t\t\t\t20171012150138_BIB37","doi-asserted-by":"crossref","unstructured":"Munoz, M., Serrador, J., Sanchez-Madrid, F. and Teixido, J. 1996. A region of the integrin VLA alpha 4 subunit involved in homotypic cell aggregation and in fibronectin but not vascular cell adhesion molecule-1 binding. J. Biol. Chem.271:2696.","DOI":"10.1074\/jbc.271.5.2696"},{"key":"key\n\t\t\t\t20171012150138_BIB38","unstructured":"Stamatoglou, S. C., Manson, M. M., Green, J. A., Mayol, X. and Hughes, R. C. 1991. Distribution of fibronectin and fibronectin-binding proteins, AGp110 and integrin alpha 5 beta 1, during chemically induced hepatocarcinogenesis in adult rats. J. Cell. Sci.100(Pt 3):599."},{"key":"key\n\t\t\t\t20171012150138_BIB39","unstructured":"Cardones, A. R., Murakami, T. and Hwang, S. T. 2003. CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin. Cancer Res.63:6751."},{"key":"key\n\t\t\t\t20171012150138_BIB40","doi-asserted-by":"crossref","unstructured":"Wright, N., Hidalgo, A., Rodriguez-Frade, J. M. et al.2002. The chemokine stromal cell-derived factor-1 alpha modulates alpha 4 beta 7 integrin-mediated lymphocyte adhesion to mucosal addressin cell adhesion molecule-1 and fibronectin. J. Immunol.168:5268.","DOI":"10.4049\/jimmunol.168.10.5268"},{"key":"key\n\t\t\t\t20171012150138_BIB41","doi-asserted-by":"crossref","unstructured":"Hidalgo, A., Sanz-Rodriguez, F., Rodriguez-Fernandez, J. L. et al.2001. Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic progenitor cells. Exp. Hematol.29:345.","DOI":"10.1016\/S0301-472X(00)00668-8"},{"key":"key\n\t\t\t\t20171012150138_BIB42","doi-asserted-by":"crossref","unstructured":"Phillips, R. and Ager, A. 2002. Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells. Eur. J. Immunol.32:837.","DOI":"10.1002\/1521-4141(200203)32:3<837::AID-IMMU837>3.0.CO;2-Q"},{"key":"key\n\t\t\t\t20171012150138_BIB43","doi-asserted-by":"crossref","unstructured":"Blades, M. C., Manzo, A., Ingegnoli, F. et al.2002. Stromal cell-derived factor 1 (CXCL12) induces human cell migration into human lymph nodes transplanted into SCID mice. J. Immunol.168:4308.","DOI":"10.4049\/jimmunol.168.9.4308"},{"key":"key\n\t\t\t\t20171012150138_BIB44","unstructured":"Brown, M. J., Nijhara, R., Hallam, J. A. et al.2003. Chemokine stimulation of human peripheral blood T lymphocytes induces rapid dephosphorylation of ERM proteins, which facilitates loss of microvilli and polarization. Blood102:3890."},{"key":"key\n\t\t\t\t20171012150138_BIB45","doi-asserted-by":"crossref","unstructured":"Okabe, S., Fukuda, S. and Broxmeyer, H. E. 2002. Activation of Wiskott-Aldrich syndrome protein and its association with other proteins by stromal cell-derived factor-1alpha is associated with cell migration in a T-lymphocyte line. Exp. Hematol.30:761.","DOI":"10.1016\/S0301-472X(02)00823-8"},{"key":"key\n\t\t\t\t20171012150138_BIB46","doi-asserted-by":"crossref","unstructured":"Erickson, J. W. and Cerione, R. A. 2001. Multiple roles for Cdc42 in cell regulation. Curr. Opin. Cell Biol.13:153.","DOI":"10.1016\/S0955-0674(00)00192-7"},{"key":"key\n\t\t\t\t20171012150138_BIB47","doi-asserted-by":"crossref","unstructured":"Nishita, M., Aizawa, H. and Mizuno, K. 2002. Stromal cell-derived factor 1alpha activates LIM kinase 1 and induces cofilin phosphorylation for T-cell chemotaxis. Mol. Cell. Biol.22:774.","DOI":"10.1128\/MCB.22.3.774-783.2002"},{"key":"key\n\t\t\t\t20171012150138_BIB48","doi-asserted-by":"crossref","unstructured":"Majka, M., Ratajczak, J., Kowalska, M. A. and Ratajczak, M. Z. 2000. Binding of stromal derived factor-1alpha (SDF-1alpha) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42\/44 (MAPK), ELK-1 transcription factor and serine\/threonine kinase AKT. Eur. J. Haematol.64:164.","DOI":"10.1034\/j.1600-0609.2000.90112.x"},{"key":"key\n\t\t\t\t20171012150138_BIB49","doi-asserted-by":"crossref","unstructured":"Floridi, F., Trettel, F., Di Bartolomeo, S., Ciotti, M. T. and Limatola, C. 2003. Signalling pathways involved in the chemotactic activity of CXCL12 in cultured rat cerebellar neurons and CHP100 neuroepithelioma cells. J. Neuroimmunol.135:38.","DOI":"10.1016\/S0165-5728(02)00432-0"},{"key":"key\n\t\t\t\t20171012150138_BIB50","doi-asserted-by":"crossref","unstructured":"Ticchioni, M., Charvet, C., Noraz, N. et al.2002. Signaling through ZAP-70 is required for CXCL12-mediated T-cell transendothelial migration. Blood99:3111.","DOI":"10.1182\/blood.V99.9.3111"},{"key":"key\n\t\t\t\t20171012150138_BIB51","doi-asserted-by":"crossref","unstructured":"Inngjerdingen, M., Torgersen, K. M. and Maghazachi, A. A. 2002. Lck is required for stromal cell-derived factor 1 alpha (CXCL12)-induced lymphoid cell chemotaxis. Blood99:4318.","DOI":"10.1182\/blood.V99.12.4318"},{"key":"key\n\t\t\t\t20171012150138_BIB52","doi-asserted-by":"crossref","unstructured":"Vermi, W., Blanzuoli, L., Kraus, M. D. et al.1999. The spleen in the Wiskott-Aldrich syndrome: histopathologic abnormalities of the white pulp correlate with the clinical phenotype of the disease. Am. J. Surg. Pathol.23:182.","DOI":"10.1097\/00000478-199902000-00007"},{"key":"key\n\t\t\t\t20171012150138_BIB53","doi-asserted-by":"crossref","unstructured":"Zhou, L. J. and Tedder, T. F. 1995. A distinct pattern of cytokine gene expression by human CD83+ blood dendritic cells. Blood86:3295.","DOI":"10.1182\/blood.V86.9.3295.bloodjournal8693295"},{"key":"key\n\t\t\t\t20171012150138_BIB54","doi-asserted-by":"crossref","unstructured":"Snapper, S. B., Meelu, P., Nguyen, D. et al.2005. WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo. J. Leukoc. Biol.77:993.","DOI":"10.1189\/jlb.0804444"},{"key":"key\n\t\t\t\t20171012150138_BIB55","doi-asserted-by":"crossref","unstructured":"Krawczyk, C., Oliveira-dos-Santos, A., Sasaki, T. et al.2002. Vav1 controls integrin clustering and MHC\/peptide-specific cell adhesion to antigen-presenting cells. Immunity16:331.","DOI":"10.1016\/S1074-7613(02)00291-1"},{"key":"key\n\t\t\t\t20171012150138_BIB56","doi-asserted-by":"crossref","unstructured":"Haddad, E., Cramer, E., Riviere, C. et al.1999. The thrombocytopenia of Wiskott Aldrich syndrome is not related to a defect in proplatelet formation. Blood94:509.","DOI":"10.1182\/blood.V94.2.509.414k09_509_518"},{"key":"key\n\t\t\t\t20171012150138_BIB57","doi-asserted-by":"crossref","unstructured":"Majka, M., Janowska-Wieczorek, A., Ratajczak, J. et al.2000. Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis. Blood96:4142.","DOI":"10.1182\/blood.V96.13.4142.h8004142_4142_4151"},{"key":"key\n\t\t\t\t20171012150138_BIB58","unstructured":"Sela, U., Ganor, S., Hecht, I. et al.2004. Allicin inhibits SDF-1alpha-induced T cell interactions with fibronectin and endothelial cells by down-regulating cytoskeleton rearrangement, Pyk-2 phosphorylation and VLA-4 expression. Immunology111:391."},{"key":"key\n\t\t\t\t20171012150138_BIB59","doi-asserted-by":"crossref","unstructured":"Brill, A., Franitza, S., Lider, O. and Hershkoviz, R. 2001. Regulation of T-cell interaction with fibronectin by transforming growth factor-beta is associated with altered Pyk2 phosphorylation. Immunology104:149.","DOI":"10.1046\/j.1365-2567.2001.01283.x"},{"key":"key\n\t\t\t\t20171012150138_BIB60","doi-asserted-by":"crossref","unstructured":"Li, Z., Hannigan, M., Mo, Z. et al.2003. Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell114:215.","DOI":"10.1016\/S0092-8674(03)00559-2"},{"key":"key\n\t\t\t\t20171012150138_BIB61","doi-asserted-by":"crossref","unstructured":"Martinez-Quiles, N., Rohatgi, R., Anton, I. M. et al.2001. WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nat. Cell Biol.3:484.","DOI":"10.1038\/35074551"},{"key":"key\n\t\t\t\t20171012150138_BIB62","doi-asserted-by":"crossref","unstructured":"Derry, J. M., Kerns, J. A., Weinberg, K. I. et al.1995. WASP gene mutations in Wiskott-Aldrich syndrome and X-linked thrombocytopenia. Hum. Mol. Genet.4:1127.","DOI":"10.1093\/hmg\/4.7.1127"}],"container-title":["International Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/intimm\/article-pdf\/18\/2\/221\/1919407\/dxh310.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T10:19:18Z","timestamp":1683195558000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/intimm\/article\/18\/2\/221\/664515\/WIP-and-WASP-play-complementary-roles-in-T-cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,1]]},"references-count":62,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,9,1]]},"published-print":{"date-parts":[[2006,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/intimm\/dxh310","relation":{},"ISSN":["1460-2377","0953-8178"],"issn-type":[{"value":"1460-2377","type":"electronic"},{"value":"0953-8178","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,2]]},"published":{"date-parts":[[2005,9,1]]}}}