{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:37:45Z","timestamp":1792679865318,"version":"4.5.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1093\/intimm\/dxp050","type":"journal-article","created":{"date-parts":[[2009,6,11]],"date-time":"2009-06-11T00:59:52Z","timestamp":1244681992000},"page":"843-858","source":"Crossref","is-referenced-by-count":208,"title":["The analysis of the functions of human B and T cells in humanized NOD\/shi-scid\/\u03b3cnull (NOG) mice (hu-HSC NOG mice)"],"prefix":"10.1093","volume":"21","author":[{"given":"Yohei","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Okajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Shiokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Katano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Minegishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Minegishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Sugamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,6,10]]},"reference":[{"key":"key\n\t\t\t\t20170522171258_bib1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1084\/jem.178.1.257","article-title":"Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody","volume":"178","author":"Grabstein","year":"1993","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170522171258_bib2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4049\/jimmunol.154.1.58","article-title":"The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34","volume":"154","author":"Dittel","year":"1995","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1600-065X.1995.tb00095.x","article-title":"Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development","volume":"148","author":"Leonard","year":"1995","journal-title":"Immunol. Rev."},{"key":"key\n\t\t\t\t20170522171258_bib4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.immuni.2008.04.003","article-title":"CD28 superagonists: what makes the difference in humans?","volume":"28","author":"Schraven","year":"2008","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170522171258_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nri2017","article-title":"Humanized mice in translational biomedical research","volume":"7","author":"Shultz","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.immuni.2007.05.001","article-title":"Human-hemato-lymphoid-system mice: opportunities and challenges","volume":"26","author":"Manz","year":"2007","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170522171258_bib7","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.4049\/jimmunol.176.4.2053","article-title":"Experimental models to study development and function of the human immune system in vivo","volume":"176","author":"Legrand","year":"2006","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.immuni.2007.05.011","article-title":"Immune-cell lineage commitment: translation from mice to humans","volume":"26","author":"Payne","year":"2007","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170522171258_bib9","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1084\/jem.20051547","article-title":"Humanized mice: are we there yet?","volume":"202","author":"Macchiarini","year":"2005","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170522171258_bib10","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1084\/jem.138.2.488","article-title":"Maintenance of skin xenografts of widely divergent phylogenetic origin of congenitally athymic (nude) mice","volume":"138","author":"Manning","year":"1973","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170522171258_bib11","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1126\/science.2971269","article-title":"The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function","volume":"241","author":"McCune","year":"1988","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522171258_bib12","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4049\/jimmunol.154.1.180","article-title":"Multiple defects in innate and adaptive immunologic function in NOD\/LtSz-scid mice","volume":"154","author":"Shultz","year":"1995","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib13","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1093\/intimm\/5.12.1509","article-title":"Engraftment of human lymphoid cells into newborn SCID mice leads to graft-versus-host disease","volume":"5","author":"Pflumio","year":"1993","journal-title":"Int. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/eji.1830220129","article-title":"Acute human vs. mouse graft vs. host disease in normal and immunodeficient mice","volume":"22","author":"Huppes","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib15","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/nm1296-1329","article-title":"Identification of primitive human hematopoietic cells capable of repopulating NOD\/SCID mouse bone marrow: implications for gene therapy","volume":"2","author":"Larochelle","year":"1996","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170522171258_bib16","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1182\/blood-2001-12-0207","article-title":"NOD\/SCID\/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells","volume":"100","author":"Ito","year":"2002","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170522171258_bib17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1073\/pnas.92.2.377","article-title":"Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain","volume":"92","author":"DiSanto","year":"1995","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522171258_bib18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/1074-7613(95)90047-0","article-title":"Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain","volume":"2","author":"Cao","year":"1995","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170522171258_bib19","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1182\/blood.V87.3.956.bloodjournal873956","article-title":"Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain","volume":"87","author":"Ohbo","year":"1996","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170522171258_bib20","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.4049\/jimmunol.174.10.6477","article-title":"Human lymphoid and myeloid cell development in NOD\/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells","volume":"174","author":"Shultz","year":"2005","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib21","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1182\/blood-2005-02-0516","article-title":"Development of functional human blood and immune systems in NOD\/SCID\/IL2 receptor {gamma} chain(null) mice","volume":"106","author":"Ishikawa","year":"2005","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170522171258_bib22","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1093933","article-title":"Development of a human adaptive immune system in cord blood cell-transplanted mice","volume":"304","author":"Traggiai","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522171258_bib23","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1182\/blood-2002-09-2755","article-title":"Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD\/SCID\/gammacnull mice model","volume":"102","author":"Hiramatsu","year":"2003","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170522171258_bib24","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0301-472X(03)00193-0","article-title":"Functional CD5+ B cells develop predominantly in the spleen of NOD\/SCID\/gammac(null) (NOG) mice transplanted either with human umbilical cord blood, bone marrow, or mobilized peripheral blood CD34+ cells","volume":"31","author":"Matsumura","year":"2003","journal-title":"Exp. Hematol."},{"key":"key\n\t\t\t\t20170522171258_bib25","doi-asserted-by":"crossref","first-page":"15951","DOI":"10.1073\/pnas.0604493103","article-title":"Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-\/-gamma c-\/- mice","volume":"103","author":"Baenziger","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522171258_bib26","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/0092-8674(91)90448-8","article-title":"Mice lacking MHC class II molecules","volume":"66","author":"Cosgrove","year":"1991","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522171258_bib27","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1538\/expanim.57.471","article-title":"Establishing EGFP congenic mice in a NOD\/Shi-scid IL2Rg(null) (NOG) genetic background using a marker-assisted selection protocol (MASP)","volume":"57","author":"Suemizu","year":"2008","journal-title":"Exp. Anim."},{"key":"key\n\t\t\t\t20170522171258_bib28","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1182\/blood.V92.11.4317","article-title":"Flow cytometric diagnosis of the cell lineage and developmental stage of acute lymphoblastic leukemia by novel monoclonal antibodies specific to human pre-B-cell receptor","volume":"92","author":"Tsuganezawa","year":"1998","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170522171258_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1089\/104303401450942","article-title":"Simplified retroviral vector gcsap with murine stem cell virus long terminal repeat allows high and continued expression of enhanced green fluorescent protein by human hematopoietic progenitors engrafted in nonobese diabetic\/severe combined immunodeficient mice","volume":"12","author":"Kaneko","year":"2001","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20170522171258_bib30","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/sj.gt.3301206","article-title":"Plat-E: an efficient and stable system for transient packaging of retroviruses","volume":"7","author":"Morita","year":"2000","journal-title":"Gene Ther."},{"key":"key\n\t\t\t\t20170522171258_bib31","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.4049\/jimmunol.167.6.3250","article-title":"T cell selection and differential activation on structurally related HLA-DR4 ligands","volume":"167","author":"Gebe","year":"2001","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib32","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1038\/nprot.2006.409","article-title":"Use of a lentivirus\/VSV pseudotype virus for highly efficient genetic redirection of human peripheral blood lymphocytes","volume":"1","author":"Simmons","year":"2006","journal-title":"Nat. Protoc."},{"key":"key\n\t\t\t\t20170522171258_bib33","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1182\/blood-2004-11-4284","article-title":"Identification and characterization of circulating human transitional B cells","volume":"105","author":"Sims","year":"2005","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170522171258_bib34","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.4049\/jimmunol.175.4.2647","article-title":"Mobilization of human lymphoid progenitors after treatment with granulocyte colony-stimulating factor","volume":"175","author":"Imamura","year":"2005","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib35","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.4049\/jimmunol.179.6.3662","article-title":"Characterization of early stages of human B cell development by gene expression profiling","volume":"179","author":"Hystad","year":"2007","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib36","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nri1688","article-title":"Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation","volume":"5","author":"Leonard","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib37","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.4049\/jimmunol.173.9.5361","article-title":"Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6","volume":"173","author":"Ozaki","year":"2004","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib38","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.immuni.2005.09.005","article-title":"Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells","volume":"23","author":"Choi","year":"2005","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170522171258_bib39","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4049\/jimmunol.169.1.204","article-title":"Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic\/Shi-scid, IL-2 receptor gamma null mice","volume":"169","author":"Yahata","year":"2002","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib40","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1093\/intimm\/dxf087","article-title":"The in vivo development of human T cells from CD34(+) cells in the murine thymic environment","volume":"14","author":"Saito","year":"2002","journal-title":"Int. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib41","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1084\/jem.20080866","article-title":"Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla","volume":"205","author":"McCaughtry","year":"2008","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170522171258_bib42","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1182\/blood-2006-01-0190","article-title":"Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in \u201chuman immune system\u201d Rag2(-\/-)gammac(-\/-) mice","volume":"108","author":"Legrand","year":"2006","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170522171258_bib43","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.4049\/jimmunol.175.7.4374","article-title":"The death receptor Fas (CD95\/APO-1) mediates the deletion of T lymphocytes undergoing homeostatic proliferation","volume":"175","author":"Fortner","year":"2005","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170522171258_bib44","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/nm1431","article-title":"Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1","volume":"12","author":"Melkus","year":"2006","journal-title":"Nat. Med."},{"key":"key\n\t\t\t\t20170522171258_bib45","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1084\/jem.180.5.1817","article-title":"Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras","volume":"180","author":"Tary-Lehmann","year":"1994","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170522171258_bib46","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1086\/590502","article-title":"A new humanized mouse model of Epstein-Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responses","volume":"198","author":"Yajima","year":"2008","journal-title":"J. Infect. Dis."},{"key":"key\n\t\t\t\t20170522171258_bib47","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.cell.2008.06.034","article-title":"T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice","volume":"134","author":"Kumar","year":"2008","journal-title":"Cell"}],"container-title":["International Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/intimm\/article-pdf\/21\/7\/843\/17413673\/dxp050.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T16:57:29Z","timestamp":1685033849000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/intimm\/article-lookup\/doi\/10.1093\/intimm\/dxp050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,10]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2009,6,10]]},"published-print":{"date-parts":[[2009,7]]}},"URL":"https:\/\/doi.org\/10.1093\/intimm\/dxp050","relation":{},"ISSN":["1460-2377","0953-8178"],"issn-type":[{"value":"1460-2377","type":"electronic"},{"value":"0953-8178","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6,10]]}}}