{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T11:30:08Z","timestamp":1784287808889,"version":"3.55.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1093\/intimm\/dxp086","type":"journal-article","created":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T00:59:03Z","timestamp":1252371543000},"page":"1239-1249","source":"Crossref","is-referenced-by-count":9,"title":["Recombinant YopJ induces apoptosis in murine peritoneal macrophages in vitro: involvement of mitochondrial death pathway"],"prefix":"10.1093","volume":"21","author":[{"given":"Ashok Kumar","family":"Pandey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajit","family":"Sodhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,9,7]]},"reference":[{"key":"key\n\t\t\t\t20170710092949_bib1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/clinids\/9.1.64","article-title":"Yersinia enterocolitica, a primary model for bacterial invasiveness","volume":"9","author":"Cornelis","year":"1987","journal-title":"Rev. Infect. Dis."},{"key":"key\n\t\t\t\t20170710092949_bib2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1128\/CMR.10.2.257","article-title":"Yersinia enterocolitica: the charisma continues","volume":"10","author":"Bottone","year":"1997","journal-title":"Clin. Microbiol. Rev."},{"key":"key\n\t\t\t\t20170710092949_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1128\/CMR.4.3.309","article-title":"Factors promoting acute and chronic diseases caused by yersiniae","volume":"4","author":"Brubaker","year":"1991","journal-title":"Clin. Microbiol. Rev."},{"key":"key\n\t\t\t\t20170710092949_bib4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1462-5822.2007.01109.x","article-title":"Yersinia outer proteins: Yops","volume":"10","author":"Trosky","year":"2008","journal-title":"Cell. Microbiol."},{"key":"key\n\t\t\t\t20170710092949_bib5","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1046\/j.1365-2958.1997.2731623.x","article-title":"The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells","volume":"23","author":"Cornelis","year":"1997","journal-title":"Mol. Microbiol."},{"key":"key\n\t\t\t\t20170710092949_bib6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1083\/jcb.200205077","article-title":"Yersinia type III secretion: send in the effectors","volume":"158","author":"Cornelis","year":"2002","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170710092949_bib7","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1093\/emboj\/16.10.2730","article-title":"Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions","volume":"16","author":"Black","year":"1997","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170710092949_bib8","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1093\/emboj\/16.9.2307","article-title":"The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions","volume":"16","author":"Persson","year":"1997","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170710092949_bib9","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1126\/science.285.5435.1920","article-title":"Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector","volume":"285","author":"Orth","year":"1999","journal-title":"Science"},{"key":"key\n\t\t\t\t20170710092949_bib10","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1046\/j.1365-2958.1998.00851.x","article-title":"The yopJ locus is required for Yersinia-mediated inhibition of NF-kappaB activation and cytokine expression: YopJ contains a eukaryotic SH2-like domain that is essential for its repressive activity","volume":"28","author":"Schesser","year":"1998","journal-title":"Mol. Microbiol."},{"key":"key\n\t\t\t\t20170710092949_bib11","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1128\/IAI.65.11.4813-4821.1997","article-title":"Interaction of Yersinia enterocolitica with macrophages leads to macrophage cell death through apoptosis","volume":"65","author":"Ruckdeschel","year":"1997","journal-title":"Infect. Immun."},{"key":"key\n\t\t\t\t20170710092949_bib12","doi-asserted-by":"crossref","first-page":"10385","DOI":"10.1073\/pnas.94.19.10385","article-title":"Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death","volume":"94","author":"Monack","year":"1997","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170710092949_bib13","doi-asserted-by":"crossref","first-page":"12638","DOI":"10.1073\/pnas.94.23.12638","article-title":"Yersinia enterocolitica induces apoptosis in macrophages by a process requiring functional type III secretion and translocation mechanisms and involving YopP, presumably acting as an effector protein","volume":"94","author":"Mills","year":"1997","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170710092949_bib14","doi-asserted-by":"crossref","first-page":"7939","DOI":"10.4049\/jimmunol.174.12.7939","article-title":"Inhibition of MAPK and NF-\u03baB pathways is necessary for rapid apoptosis in macrophages infected with Yersinia","volume":"174","author":"Zhang","year":"2005","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170710092949_bib15","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1084\/jem.188.11.2127","article-title":"Yersinia-induced apoptosis in vivo aids in the establishment of a systemic infection of mice","volume":"188","author":"Monack","year":"1998","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170710092949_bib16","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1126\/science.290.5496.1594","article-title":"Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease","volume":"290","author":"Orth","year":"2000","journal-title":"Science"},{"key":"key\n\t\t\t\t20170710092949_bib17","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1128\/IAI.72.12.7045-7054.2004","article-title":"Yersinia enterocolitica induces apoptosis and inhibits surface molecule expression and cytokine production in murine dendritic cells","volume":"72","author":"Erfurth","year":"2004","journal-title":"Infect. Immun."},{"key":"key\n\t\t\t\t20170710092949_bib18","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.4049\/jimmunol.171.8.4294","article-title":"A dominant role of Toll-like receptor 4 in the signaling of apoptosis in bacteria-faced macrophages","volume":"171","author":"Haase","year":"2003","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170710092949_bib19","doi-asserted-by":"crossref","first-page":"8209","DOI":"10.4049\/jimmunol.175.12.8209","article-title":"Yersinia outer protein P suppresses TGF-beta-activated kinase-1 activity to impair innate immune signaling in Yersinia enterocolitica-infected cells","volume":"175","author":"Haase","year":"2005","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170710092949_bib20","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1084\/jem.20051194","article-title":"Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation","volume":"202","author":"Zhou","year":"2005","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170710092949_bib21","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/sj.embor.7400754","article-title":"The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway","volume":"7","author":"Thiefes","year":"2006","journal-title":"EMBO Rep."},{"key":"key\n\t\t\t\t20170710092949_bib22","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.4049\/jimmunol.166.3.1823","article-title":"Yersinia outer protein P of Yersinia enterocolitica simultaneously blocks the nuclear factor-kappa B pathway and exploits lipopolysaccharide signaling to trigger apoptosis in macrophages","volume":"166","author":"Ruckdeschel","year":"2001","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170710092949_bib23","doi-asserted-by":"crossref","first-page":"18574","DOI":"10.1073\/pnas.0608995103","article-title":"Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling","volume":"103","author":"Mittal","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170710092949_bib24","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1126\/science.1126867","article-title":"Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation","volume":"312","author":"Mukherjee","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20170710092949_bib25","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1146\/annurev.immunol.17.1.781","article-title":"The central effectors of cell death in the immune system","volume":"17","author":"Rathmell","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"key\n\t\t\t\t20170710092949_bib26","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170710092949_bib27","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/sj.cdd.4401160","article-title":"Many cuts to ruin: a comprehensive update of caspase substrates","volume":"10","author":"Fischer","year":"2003","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t20170710092949_bib28","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/35085008","article-title":"Four deaths and a funeral: from caspases to alternative mechanisms","volume":"2","author":"Leist","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170710092949_bib29","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1242\/jcs.114.23.4161","article-title":"Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis","volume":"114","author":"Rudner","year":"2001","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t20170710092949_bib30","doi-asserted-by":"crossref","first-page":"5148","DOI":"10.4049\/jimmunol.171.10.5148","article-title":"Cyclopentenone prostaglandins induce lymphocyte apoptosis by activating the mitochondrial apoptosis pathway independent of external death receptor signaling","volume":"171","author":"Nencioni","year":"2003","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170710092949_bib31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0022-1759(02)00069-8","article-title":"Quantitation of mitochondrial alterations associated with apoptosis","volume":"265","author":"Castedo","year":"2002","journal-title":"J. Immunol. Methods"},{"key":"key\n\t\t\t\t20170710092949_bib32","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1128\/MCB.23.3.777-790.2003","article-title":"Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation","volume":"23","author":"Leverkus","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170710092949_bib33","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1074\/jbc.M410985200","article-title":"A central role for Bid in granzyme B-induced apoptosis","volume":"280","author":"Waterhouse","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170710092949_bib34","doi-asserted-by":"crossref","first-page":"e1375","DOI":"10.1371\/journal.pone.0001375","article-title":"Structural requirements for Yersinia YopJ inhibition of MAP kinase pathways","volume":"3","author":"Hao","year":"2008","journal-title":"PLoS ONE"},{"key":"key\n\t\t\t\t20170710092949_bib35","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1093\/emboj\/19.13.3325","article-title":"The apoptotic signaling pathway activated by Toll-like receptor-2","volume":"19","author":"Aliprantis","year":"2000","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170710092949_bib36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev.iy.02.040184.001435","article-title":"The cell biology of macrophage activation","volume":"2","author":"Adam","year":"1984","journal-title":"Annu. Rev. Immun."},{"key":"key\n\t\t\t\t20170710092949_bib37","first-page":"111","article-title":"Macrophage-mediated tumoricidal activity: mechanisms of activation and cytotoxicity","volume":"40","author":"Drysdale","year":"1988","journal-title":"Prog. Allergy"},{"key":"key\n\t\t\t\t20170710092949_bib38","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.4049\/jimmunol.170.5.2409","article-title":"The 19-kDa Mycobacterium tuberculosis protein induces macrophage apoptosis through Toll-like receptor-2","volume":"170","author":"Lopez","year":"2003","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170710092949_bib39","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/j.1462-5822.2007.00892.x","article-title":"The ESAT-6 protein of Mycobacterium tuberculosis induces apoptosis of macrophages by activating the caspase expression","volume":"9","author":"Derrick","year":"2007","journal-title":"Cell. Microbiol."},{"key":"key\n\t\t\t\t20170710092949_bib40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-0463.2006.apm_254.x","article-title":"Virulence markers of LCR plasmid in Indian isolates of Yersinia pestis","volume":"114","author":"Khushiramani","year":"2006","journal-title":"APMIS"},{"key":"key\n\t\t\t\t20170710092949_bib41","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1006\/niox.2001.0370","article-title":"Regulation of nitric oxide production by murine peritoneal macrophages treated in vitro with chemokine monocyte chemoattractant protein 1","volume":"5","author":"Biswas","year":"2001","journal-title":"Nitric Oxide"},{"key":"key\n\t\t\t\t20170710092949_bib42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"key\n\t\t\t\t20170710092949_bib43","doi-asserted-by":"crossref","first-page":"11038","DOI":"10.1074\/jbc.273.18.11038","article-title":"Production of nitric oxide by mitochondria","volume":"273","author":"Giulivi","year":"1998","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170710092949_bib44","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.micro.53.1.155","article-title":"The induction of apoptosis by bacterial pathogens","volume":"53","author":"Weinrauch","year":"1999","journal-title":"Annu. Rev. Microbiol."},{"key":"key\n\t\t\t\t20170710092949_bib45","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1084\/jem.187.7.1069","article-title":"Yersinia enterocolitica impairs activation of transcription factor NF-\u03baB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production","volume":"187","author":"Ruckdeschel","year":"1998","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170710092949_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","article-title":"Caspases: the executioner of apoptosis","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170710092949_bib47","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1083\/jcb.144.5.891","article-title":"Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis","volume":"144","author":"Desagher","year":"1999","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170710092949_bib48","doi-asserted-by":"crossref","first-page":"19706","DOI":"10.1074\/jbc.M101573200","article-title":"Yersinia enterocolitica YopP-induced apoptosis of macrophages involves the apoptotic signaling cascade upstream of bid","volume":"276","author":"Denecker","year":"2001","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170710092949_bib49","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1128\/IAI.71.3.1513-1519.2003","article-title":"Role of Toll-like receptor signaling in the apoptotic response of macrophages to Yersinia infection","volume":"71","author":"Zhang","year":"2003","journal-title":"Infect. Immun."},{"key":"key\n\t\t\t\t20170710092949_bib50","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1074\/jbc.274.2.1156","article-title":"Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1\/Fas death","volume":"274","author":"Gross","year":"1999","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170710092949_bib51","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.4049\/jimmunol.176.11.6443","article-title":"Suppression of Alveolar macrophages apoptosis prolongs survival of rats and mice with pneumocystis pneumonia","volume":"176","author":"Lasbury","year":"2006","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170710092949_bib52","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1083\/jcb.62.3.647","article-title":"Inhibition of phagocytosis and plasma membrane mobility of the cultured macrophages by cytochalasin B","volume":"62","author":"Axline","year":"1974","journal-title":"J. Cell Biol."}],"container-title":["International Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/intimm\/article-pdf\/21\/11\/1239\/18322264\/dxp086.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T12:09:16Z","timestamp":1633867756000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/intimm\/article-lookup\/doi\/10.1093\/intimm\/dxp086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,7]]},"references-count":52,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2009,9,7]]},"published-print":{"date-parts":[[2009,11]]}},"URL":"https:\/\/doi.org\/10.1093\/intimm\/dxp086","relation":{},"ISSN":["1460-2377","0953-8178"],"issn-type":[{"value":"1460-2377","type":"electronic"},{"value":"0953-8178","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9,7]]}}}