{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T06:40:09Z","timestamp":1686120009649},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1093\/intimm\/dxr031","type":"journal-article","created":{"date-parts":[[2011,6,4]],"date-time":"2011-06-04T04:07:03Z","timestamp":1307160423000},"page":"433-441","source":"Crossref","is-referenced-by-count":2,"title":["HIV-1 Nef impairs multiple T-cell functions in antigen-specific immune response in mice"],"prefix":"10.1093","volume":"23","author":[{"given":"Hideki","family":"Fujii","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Ato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Otake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-ichi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuko","family":"Tsunetsugu-Yokota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikako","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinori","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Koyasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitada","family":"Takemori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,6,3]]},"reference":[{"key":"key\n\t\t\t\t20170522171742_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S1074-7613(02)00307-2","article-title":"Live and let die: Nef functions beyond HIV replication","volume":"16","author":"Fackler","year":"2002","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170522171742_bib2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1073\/pnas.97.1.394","article-title":"The Nef protein of HIV-1 associates with rafts and primes T cells for activation","volume":"97","author":"Wang","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522171742_bib3","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1074-7613(01)00158-3","article-title":"Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators","volume":"14","author":"Simmons","year":"2001","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170522171742_bib4","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1084\/jem.20012039","article-title":"HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells","volume":"195","author":"Manninen","year":"2002","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170522171742_bib5","doi-asserted-by":"crossref","first-page":"39520","DOI":"10.1074\/jbc.M407477200","article-title":"Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-\u03baB, and AP-1 induction","volume":"279","author":"Fortin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522171742_bib6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1034\/j.1600-065X.2003.00067.x","article-title":"Chemokines in the systemic organization of immunity","volume":"195","author":"Campbell","year":"2003","journal-title":"Immunol. Rev."},{"key":"key\n\t\t\t\t20170522171742_bib7","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.1371\/journal.pbio.0020006","article-title":"HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis","volume":"2","author":"Janardhan","year":"2004","journal-title":"PLoS Biol."},{"key":"key\n\t\t\t\t20170522171742_bib8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(00)81748-1","article-title":"Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice","volume":"95","author":"Hanna","year":"1998","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522171742_bib9","doi-asserted-by":"crossref","first-page":"11830","DOI":"10.1128\/JVI.01466-09","article-title":"Adult AIDS-like disease in a novel inducible human immunodeficiency virus type 1 Nef transgenic mouse model: CD4+ T-cell activation is Nef dependent and can occur in the absence of lymphophenia","volume":"83","author":"Rahim","year":"2009","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20170522171742_bib10","doi-asserted-by":"crossref","first-page":"5762","DOI":"10.4049\/jimmunol.178.9.5762","article-title":"T cell activation and proliferation characteristic for HIV-Nef transgenic mice is lymphopenia induced","volume":"178","author":"Koenen","year":"2007","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170522171742_bib11","doi-asserted-by":"crossref","first-page":"13784","DOI":"10.1073\/pnas.250356297","article-title":"Transgenic expression of the coxsackie\/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells","volume":"97","author":"Wan","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522171742_bib12","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1126\/science.2125367","article-title":"Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo","volume":"250","author":"Murphy","year":"1990","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522171742_bib13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.7883\/yoken1952.47.157","article-title":"A simple and efficient method for purification of infectious recombinant adenovirus","volume":"47","author":"Kanegae","year":"1994","journal-title":"Jpn. J. Med. Sci. Biol."},{"key":"key\n\t\t\t\t20170522171742_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1074-7613(01)00100-5","article-title":"Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire","volume":"14","author":"Takahashi","year":"2001","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170522171742_bib15","doi-asserted-by":"crossref","first-page":"46079","DOI":"10.1074\/jbc.M204698200","article-title":"HIV Nef inhibits T cell migration","volume":"277","author":"Choe","year":"2002","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522171742_bib16","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1146\/annurev.immunol.22.012703.104554","article-title":"Control of T cell viability","volume":"22","author":"Marrack","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"key\n\t\t\t\t20170522171742_bib17","doi-asserted-by":"crossref","first-page":"9277","DOI":"10.1073\/pnas.161272698","article-title":"IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4+ T cells","volume":"98","author":"Dardalhon","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522171742_bib18","doi-asserted-by":"crossref","first-page":"11229","DOI":"10.1073\/pnas.95.19.11229","article-title":"Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity","volume":"95","author":"Craig","year":"1998","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522171742_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jcv.2008.03.026","article-title":"Downregulation of CCR5 on activated CD4 T cells in HIV-infected Indians","volume":"43","author":"Dubey","year":"2008","journal-title":"J. Clin. Virol."},{"key":"key\n\t\t\t\t20170522171742_bib20","doi-asserted-by":"crossref","first-page":"11141","DOI":"10.1128\/JVI.01556-06","article-title":"Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection","volume":"80","author":"Venzke","year":"2006","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20170522171742_bib21","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1084\/jem.188.12.2205","article-title":"Viral immune evasion due to persistence of activated T cells without effector function","volume":"188","author":"Zajac","year":"1998","journal-title":"J Exp Med."},{"key":"key\n\t\t\t\t20170522171742_bib22","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1084\/jem.191.6.1017","article-title":"Regulation of fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase","volume":"191","author":"Zhang","year":"2000","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20170522171742_bib23","doi-asserted-by":"crossref","first-page":"5128","DOI":"10.4049\/jimmunol.152.10.5128","article-title":"HIV-1 Nef activity in murine T cells. CD4 modulation and positive enhancement","volume":"152","author":"Rhee","year":"1994","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20170522171742_bib24","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1128\/JVI.02691-06","article-title":"Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice","volume":"81","author":"Priceputu","year":"2007","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20170522171742_bib25","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1083\/jcb.200203043","article-title":"T cell receptor ligation induces the formation of dynamically regulated signaling assemblies","volume":"158","author":"Bunnell","year":"2002","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522171742_bib26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.immuni.2009.03.010","article-title":"The cellular context of T cell signaling","volume":"30","author":"Dustin","year":"2009","journal-title":"Immunity."},{"key":"key\n\t\t\t\t20170522171742_bib27","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.immuni.2006.02.016","article-title":"Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse","volume":"24","author":"Thoulouze","year":"2006","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20170522171742_bib28","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/intimm\/dxq047","article-title":"Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses","volume":"22","author":"Pereira","year":"2010","journal-title":"Int. Immunol."},{"key":"key\n\t\t\t\t20170522171742_bib29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/338257a0","article-title":"Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck","volume":"338","author":"Veillette","year":"1989","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522171742_bib30","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1126\/science.289.5483.1349","article-title":"Differential clustering of CD4 and CD3\u03b6 during T cell recognition","volume":"289","author":"Krummel","year":"2000","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522171742_bib31","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/ni761","article-title":"Regulation of Lck activity by CD4 and CD28 in the immunological synapse","volume":"3","author":"Holdorf","year":"2002","journal-title":"Nat. Immunol."},{"key":"key\n\t\t\t\t20170522171742_bib32","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nm0703-853","article-title":"HIV-1 pathogenesis","volume":"9","author":"Stevenson","year":"2003","journal-title":"Nat. Med."}],"container-title":["International Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/intimm\/article-pdf\/23\/7\/433\/17414429\/dxr031.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T06:16:14Z","timestamp":1686118574000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/intimm\/article-lookup\/doi\/10.1093\/intimm\/dxr031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,3]]},"references-count":32,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2011,6,3]]},"published-print":{"date-parts":[[2011,7]]}},"URL":"https:\/\/doi.org\/10.1093\/intimm\/dxr031","relation":{},"ISSN":["1460-2377","0953-8178"],"issn-type":[{"value":"1460-2377","type":"electronic"},{"value":"0953-8178","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6,3]]}}}