{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:03:32Z","timestamp":1791273812435,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Myocarditis is a common clinical cardiovascular disease, and some patients progress to dilated cardiomyopathy (DCM) with chronic heart failure. Common viral infections are the most frequent cause of myocarditis, but other pathogens and autoimmune diseases have also been implicated. Th17 cells are novel IL-17-producing effector T helper cells that play an important role in the development of autoimmune myocarditis. Furthermore, IL-17 is also important in post-myocarditis cardiac remodeling and progression to DCM. However, the mechanisms whereby IL-17 and IL-17-producing cells promote the progression of cardiac fibrosis remain unclear. We therefore investigated whether IL-17 directly induced cardiac fibrosis in experimental autoimmune myocarditis (EAM) and explored the possible molecular mechanisms. The EAM model was induced and serum IL-17 level was detected by ELISA; western blot, immunofluorescence and sirius red staining were used to analyze the collagen expression. PCR was used to assay the IL-17RA and IL-17RC. The results indicated that IL-17 induced cardiac fibrosis both in vitro and in vivo. The protein kinase C (PKC)\u03b2\/Erk1\/2\/NF-\u03baB (Nuclear Factor \u03baappa B) pathway was involved in the development of myocardial fibrosis and IL-17 contributed to cardiac fibrosis following EAM via this pathway. These results provide the first direct evidence for the involvement of the PKC\u03b2\/Erk1\/2\/NF-\u03baB signaling pathway in IL-17-induced myocardial fibrosis.<\/jats:p>","DOI":"10.1093\/intimm\/dxs056","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T01:00:18Z","timestamp":1335315618000},"page":"605-612","source":"Crossref","is-referenced-by-count":105,"title":["IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKC\u03b2\/Erk1\/2\/NF-\u03baB-dependent signaling pathway"],"prefix":"10.1093","volume":"24","author":[{"given":"Yanfang","family":"Liu","sequence":"first","affiliation":[{"name":"1Department of Immunology, Center of Clinical Medicine and Laboratory, Jiangsu University, Zhenjiang 212013, China"},{"name":"2Department of Central Laboratory, The First People\u2019 Hospital of Zhenjiang, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Zhu","sequence":"additional","affiliation":[{"name":"1Department of Immunology, Center of Clinical Medicine and Laboratory, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoliang","family":"Su","sequence":"additional","affiliation":[{"name":"1Department of Immunology, Center of Clinical Medicine and Laboratory, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Sun","sequence":"additional","affiliation":[{"name":"3Zhenjiang Key Laboratory of Medical Immunology, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Yin","sequence":"additional","affiliation":[{"name":"1Department of Immunology, Center of Clinical Medicine and Laboratory, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Yuan","sequence":"additional","affiliation":[{"name":"1Department of Immunology, Center of Clinical Medicine and Laboratory, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamak","family":"Sandoghchian","sequence":"additional","affiliation":[{"name":"1Department of Immunology, Center of Clinical Medicine and Laboratory, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Jiao","sequence":"additional","affiliation":[{"name":"3Zhenjiang Key Laboratory of Medical Immunology, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjun","family":"Wang","sequence":"additional","affiliation":[{"name":"1Department of Immunology, Center of Clinical Medicine and Laboratory, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaxi","family":"Xu","sequence":"additional","affiliation":[{"name":"1Department of Immunology, Center of Clinical Medicine and Laboratory, Jiangsu University, Zhenjiang 212013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,4,24]]},"reference":[{"key":"2023120117272377000_bib1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.pcad.2009.11.006","article-title":"Myocarditis","volume":"52","author":"Blauwet","year":"2010","journal-title":"Prog. 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