{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:51:12Z","timestamp":1722127872294},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Single nucleotide polymorphisms (SNPs) of the tumour necrosis factor alpha (TNF\u03b1) gene (TNFA) have been extensively studied and shown to be associated with an increased risk of the development of various chronic inflammatory diseases. Inflammation has been demonstrated to play a central role in the pathogenesis of chronic rhinosinusitis (CRS), and TNF\u03b1 is a key pro-inflammatory cytokine with important functions in these processes. In order to determine whether the well-known TNFA \u2013308 G&amp;gt;A SNP has a role in a genetic predisposition to CRS in the Hungarian population, we analyzed our genomic collection containing control and CRS patient samples in a case\u2013control study, and compared the genotype and allele frequencies. There was no significant difference in the observed genotype or allele frequencies between the controls and the total CRS group. However, after careful stratification of the patient group on the basis of the observed clinical symptoms, we found a significantly higher carriage rate of the rare A allele-containing genotypes among the CRS patients with nasal polyposis (NP) who also exhibited sensitivity to aspirin (acetylsalicylic acid, ASA+). It is concluded that genetic variants of the TNFA gene may affect the risk of CRS in a clinically well-defined group of CRSNP+ASA+ patients in the Hungarian population. Our results also emphasize that the group of CRS patients is not homogenous in that patients exhibiting different clinical symptoms exist. Their carried genetic predisposing factors, and as a result, the exact molecular events leading to the development of various forms of CRS, may also differ.<\/jats:p>","DOI":"10.1093\/intimm\/dxs162","type":"journal-article","created":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T23:02:14Z","timestamp":1362092534000},"page":"383-388","source":"Crossref","is-referenced-by-count":17,"title":["The \u2013308 G&amp;gt;A SNP of <i>TNFA<\/i> is a factor predisposing to chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarian individuals: conclusions of a genetic study with multiple stratifications"],"prefix":"10.1093","volume":"25","author":[{"given":"Korn\u00e9lia","family":"Szab\u00f3","sequence":"first","affiliation":[{"name":"MTA-SZTE Dematological Research Group 1 , Szeged , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Kiricsi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University of Szeged, Albert Szent-Gy\u00f6rgyi Medical and Pharmaceutical Centre 2 , Szeged , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nika","family":"R\u00e9v\u00e9sz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University Faculty of Medicine 3 , Budapest , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"V\u00f3na","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, P\u00e9cs University Faculty of Medicine 4 , P\u00e9cs , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Borsod-Aba\u00faj-Zempl\u00e9n County Hospital and University Teaching Hospital 5 , Miskolc , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Bella","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University of Szeged, Albert Szent-Gy\u00f6rgyi Medical and Pharmaceutical Centre 2 , Szeged , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilda","family":"Poly\u00e1nka","sequence":"additional","affiliation":[{"name":"MTA-SZTE Dematological Research Group 1 , Szeged , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edit","family":"Kadocsa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, University of Szeged, Albert Szent-Gy\u00f6rgyi Medical and Pharmaceutical Centre 2 , Szeged , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Kem\u00e9ny","sequence":"additional","affiliation":[{"name":"MTA-SZTE Dematological Research Group 1 , Szeged , Hungary"},{"name":"Department of Dermatology and Allergology, University of Szeged, Albert Szent-Gy\u00f6rgyi Medical and Pharmaceutical Centre 6 , Szeged , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rta","family":"Sz\u00e9ll","sequence":"additional","affiliation":[{"name":"MTA-SZTE Dematological Research Group 1 , Szeged , Hungary"},{"name":"Department of Medical Genetics, University of Szeged, Albert Szent-Gy\u00f6rgyi Medical and Pharmaceutical 7 , Budapest , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andor","family":"Hirschberg","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, St John\u2019s and North-Buda Hospitals of the Municipality of Centre 8 , Budapest , Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"2022073002090797100_CIT0001","first-page":"114","article-title":"Chronic rhinosinusitis","volume":"70","author":"Wang","year":"2011","journal-title":"Adv. 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