{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:51:45Z","timestamp":1789782705667,"version":"4.0.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cell-mediated immunity, cytokines induced during the specific immune response and T-cell populations are crucial factors for containing Mycobacterium tuberculosis infection. Recent reports suggest a cross-regulation between adrenal steroids (glucocorticoids and dehydroepiandrosterone, DHEA) and the function of antigen-presenting cells (APCs). Therefore, we investigated the role of adrenal hormones on the functional capacity of M. tuberculosis-induced dendritic cells (DCs). Cortisol significantly inhibited the functions of M. tuberculosis-induced DCs. Interestingly, the presence of DHEA enhanced the M. tuberculosis-induced expression of MHC I, MHC II and CD86 and also increased ERK1\/2 phosphorylation. Moreover, DHEA improved the production of IL-12 in response to M. tuberculosis stimulation, diminished IL-10 secretion and could not modify TNF-\u03b1 synthesis. Importantly, we observed that DHEA enhanced the antigen-specific T-cell proliferation and IFN-\u03b3 production induced by M. tuberculosis-stimulated DC. These data show for the first time the relevance of the adrenal axis (especially of DHEA) in the modulation of DC function in the context of tuberculosis, a disease where the induction of a Th1 environment by APCs is crucial for the development of an effective immune response to the mycobacteria.<\/jats:p>","DOI":"10.1093\/intimm\/dxt004","type":"journal-article","created":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T23:02:14Z","timestamp":1362092534000},"page":"405-411","source":"Crossref","is-referenced-by-count":17,"title":["Modulation of the phenotype and function of<i>Mycobacterium tuberculosis<\/i>-stimulated dendritic cells by adrenal steroids"],"prefix":"10.1093","volume":"25","author":[{"given":"Matias","family":"Angerami","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas en Retrovirus y SIDA, University of Buenos Aires 1 , Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Suarez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas en Retrovirus y SIDA, University of Buenos Aires 1 , Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda","family":"Pascutti","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas en Retrovirus y SIDA, University of Buenos Aires 1 , Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"Salomon","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas en Retrovirus y SIDA, University of Buenos Aires 1 , Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Bottasso","sequence":"additional","affiliation":[{"name":"Instituto de Inmunolog\u00eda, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Rosario 2 , Rosario , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Florencia","family":"Quiroga","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas en Retrovirus y SIDA, University of Buenos Aires 1 , Buenos Aires , Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"2022073001492351400_CIT0001","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/emmm.200900008","article-title":"Spotlight on Mycobacteria and dendritic cells: will novel targets to fight tuberculosis emerge?","volume":"1","author":"Mortellaro","year":"2009","journal-title":"EMBO Mol. Med."},{"key":"2022073001492351400_CIT0002","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.coi.2005.06.006","article-title":"Host innate and Th1 responses and the bacterial factors that control Mycobacterium tuberculosis infection","volume":"17","author":"Salgame","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"2022073001492351400_CIT0003","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1530\/eje.0.1430687","article-title":"Opposing effects of dehydroepiandrosterone and dexamethasone on the generation of monocyte-derived dendritic cells","volume":"143","author":"Canning","year":"2000","journal-title":"Eur. J. Endocrinol."},{"key":"2022073001492351400_CIT0004","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2567.2007.02637.x","article-title":"Corticosterone impairs dendritic cell maturation and function","volume":"122","author":"Elftman","year":"2007","journal-title":"Immunology"},{"key":"2022073001492351400_CIT0005","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s10517-009-0619-7","article-title":"Effect of dehydroepiandrosterone sulfate on maturation and functional properties of interferon-alpha-induced dendritic cells","volume":"148","author":"Leplina","year":"2009","journal-title":"Bull. Exp. Biol. Med."},{"key":"2022073001492351400_CIT0006","doi-asserted-by":"crossref","first-page":"S103","DOI":"10.1016\/S0306-4530(97)00005-X","article-title":"Antiglucocorticoid function of androstenetriol","volume":"22","author":"Loria","year":"1997","journal-title":"Psychoneuroendocrinology"},{"key":"2022073001492351400_CIT0007","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0899-9007(99)00111-2","article-title":"Correlation between increased cortisol:DHEA ratio and malnutrition in HIV-positive men","volume":"15","author":"Christeff","year":"1999","journal-title":"Nutrition"},{"key":"2022073001492351400_CIT0008","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-3083.2007.01952.x","article-title":"Altered cortisol\/DHEA ratio in tuberculosis patients and its relationship with abnormalities in the mycobacterial-driven cytokine production by peripheral blood mononuclear cells","volume":"66","author":"Bozza","year":"2007","journal-title":"Scand. J. Immunol."},{"key":"2022073001492351400_CIT0009","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jsbmb.2009.12.016","article-title":"Dehydroepiandrosterone as a regulator of immune cell function","volume":"120","author":"Hazeldine","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"2022073001492351400_CIT0010","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1749-6632.2008.03976.x","article-title":"The adrenal steroid response during tuberculosis and its effects on the mycobacterial-driven IFN-gamma production of patients and their household contacts","volume":"1153","author":"Bozza","year":"2009","journal-title":"Ann. NY Acad. Sci."},{"key":"2022073001492351400_CIT0011","doi-asserted-by":"crossref","first-page":"e33061","DOI":"10.1371\/journal.pone.0033061","article-title":"Dynamics of adrenal steroids are related to variations in Th1 and Treg populations during Mycobacterium tuberculosis infection in HIV positive persons","volume":"7","author":"Quiroga","year":"2012","journal-title":"PLoS ONE"},{"key":"2022073001492351400_CIT0012","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1084\/jem.20091579","article-title":"Spermatozoa capture HIV-1 through heparan sulfate and efficiently transmit the virus to dendritic cells","volume":"206","author":"Ceballos","year":"2009","journal-title":"J. Exp. Med."},{"key":"2022073001492351400_CIT0013","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.4049\/jimmunol.173.6.4120","article-title":"Activation of signaling lymphocytic activation molecule triggers a signaling cascade that enhances Th1 responses in human intracellular infection","volume":"173","author":"Quiroga","year":"2004","journal-title":"J. Immunol."},{"key":"2022073001492351400_CIT0014","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.4049\/jimmunol.0903299","article-title":"PE_PGRS antigens of Mycobacterium tuberculosis induce maturation and activation of human dendritic cells","volume":"184","author":"Bansal","year":"2010","journal-title":"J. Immunol."},{"key":"2022073001492351400_CIT0015","doi-asserted-by":"crossref","first-page":"36511","DOI":"10.1074\/jbc.M110.158055","article-title":"Src homology 3-interacting domain of Rv1917c of Mycobacterium tuberculosis induces selective maturation of human dendritic cells by regulating PI3K-MAPK-NF-kappaB signaling and drives Th2 immune responses","volume":"285","author":"Bansal","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2022073001492351400_CIT0016","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1471-4914(03)00027-3","article-title":"A fatal attraction: Mycobacterium tuberculosis and HIV-1 target DC-SIGN to escape immune surveillance","volume":"9","author":"van Kooyk","year":"2003","journal-title":"Trends Mol. Med."},{"key":"2022073001492351400_CIT0017","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbi.2006.01.002","article-title":"Stress presents a problem for dendritic cells: corticosterone and the fate of MHC class I antigen processing and presentation","volume":"20","author":"Truckenmiller","year":"2006","journal-title":"Brain Behav. Immun."},{"key":"2022073001492351400_CIT0018","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1046\/j.1365-2249.1999.00811.x","article-title":"Glucocorticoids modulate the development of dendritic cells from blood precursors","volume":"115","author":"van den Heuvel","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"2022073001492351400_CIT0019","first-page":"225","article-title":"Differential suppression of dendritic cell cytokine production by anti-inflammatory drugs","volume":"158","author":"Toebak","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"2022073001492351400_CIT0020","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.4049\/jimmunol.162.11.6473","article-title":"Glucocorticoids affect human dendritic cell differentiation and maturation","volume":"162","author":"Piemonti","year":"1999","journal-title":"J. Immunol."},{"key":"2022073001492351400_CIT0021","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.micinf.2007.02.002","article-title":"Tumor necrosis factor is critical to control tuberculosis infection","volume":"9","author":"Jacobs","year":"2007","journal-title":"Microbes Infect."},{"key":"2022073001492351400_CIT0022","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/mi.2011.7","article-title":"The role of IL-10 in immune regulation during M. tuberculosis infection","volume":"4","author":"Redford","year":"2011","journal-title":"Mucosal Immunol."},{"key":"2022073001492351400_CIT0023","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.4049\/jimmunol.166.12.7033","article-title":"Infection of human macrophages and dendritic cells with Mycobacterium tuberculosis induces a differential cytokine gene expression that modulates T cell response","volume":"166","author":"Giacomini","year":"2001","journal-title":"J. Immunol."},{"key":"2022073001492351400_CIT0024","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0531-5565(95)02033-0","article-title":"Dysregulation of IL-10 production with aging: possible linkage to the age-associated decline in DHEA and its sulfated derivative","volume":"31","author":"Spencer","year":"1996","journal-title":"Exp. Gerontol."},{"key":"2022073001492351400_CIT0025","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.4049\/jimmunol.173.5.3392","article-title":"IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition","volume":"173","author":"Jang","year":"2004","journal-title":"J. Immunol."},{"key":"2022073001492351400_CIT0026","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/icb.2010.22","article-title":"Mycobacterium tuberculosis impairs dendritic cell response by altering CD1b, DC-SIGN and MR profile","volume":"88","author":"Balboa","year":"2010","journal-title":"Immunol. Cell Biol."},{"key":"2022073001492351400_CIT0027","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1210\/jc.2003-031441","article-title":"Dehydroepiandrosterone-sulfate inhibits nuclear factor-kappaB-dependent transcription in hepatocytes, possibly through antioxidant effect","volume":"89","author":"Iwasaki","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2022073001492351400_CIT0028","doi-asserted-by":"crossref","first-page":"6777","DOI":"10.4049\/jimmunol.178.11.6777","article-title":"Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells","volume":"178","author":"Wang","year":"2007","journal-title":"J. Immunol."},{"key":"2022073001492351400_CIT0029","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1086\/518937","article-title":"Immunotherapeutics for tuberculosis in experimental animals: is there a common pathway activated by effective protocols?","volume":"196","author":"Rook","year":"2007","journal-title":"J. Infect. Dis."},{"key":"2022073001492351400_CIT0030","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1440-1843.2010.01739.x","article-title":"The immunology of tuberculosis: from bench to bedside","volume":"15","author":"Dheda","year":"2010","journal-title":"Respirology"}],"container-title":["International Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/intimm\/article-pdf\/25\/7\/405\/45192757\/intimm_25_7_405.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/intimm\/article-pdf\/25\/7\/405\/45192757\/intimm_25_7_405.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T20:36:12Z","timestamp":1688070972000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/intimm\/article\/25\/7\/405\/732516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,26]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,2,26]]},"published-print":{"date-parts":[[2013,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/intimm\/dxt004","relation":{},"ISSN":["1460-2377","0953-8178"],"issn-type":[{"value":"1460-2377","type":"electronic"},{"value":"0953-8178","type":"print"}],"subject":[],"published-other":{"date-parts":[[2013,7]]},"published":{"date-parts":[[2013,2,26]]}}}