{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:50:28Z","timestamp":1791003028207,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T00:00:00Z","timestamp":1379030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CD4+ T cells that recognize dietary gluten antigens presented by the disease-associated HLA-DQ2 or DQ8 molecules are central players in coeliac disease. Unbiased sequencing of the human TCR\u03b1 variable (TRAV) and humanTCR\u03b2 variable (TRBV) genes of 68 HLA-DQ2.5-glia-\u03b12-specific T cells from coeliac disease patients confirmed previous reports of over-usage of the TRBV7-2 gene segment, a conserved Arg residue in the complementarity-determining region (CDR) 3\u03b2 loop and prevalent usage of the canonical ASSxRxTDTQY CDR3\u03b2 loop among T cells with this specificity. In 30 clones that had the canonical TCR\u03b2 chain, we found a strict usage of the TRAV26-1 gene segment in the TCR\u03b1 chain. There was variable usage of the TRAJ genes and diverse CDR3\u03b1 sequences with no apparent conserved motifs. This study extends previous reports on biased TCR usage in both HLA-DQ2.5- and DQ8-restricted gluten-specific TCRs and provides data for further studies on TRAV and TRBV pairing.<\/jats:p>","DOI":"10.1093\/intimm\/dxt037","type":"journal-article","created":{"date-parts":[[2013,9,14]],"date-time":"2013-09-14T03:09:26Z","timestamp":1379128166000},"page":"13-19","source":"Crossref","is-referenced-by-count":57,"title":["Biased usage and preferred pairing of \u03b1- and \u03b2-chains of TCRs specific for an immunodominant gluten epitope in coeliac disease"],"prefix":"10.1093","volume":"26","author":[{"given":"Shuo-Wang","family":"Qiao","sequence":"first","affiliation":[{"name":"Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital - Rikshospitalet 1 , 0372 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asbj\u00f8rn","family":"Christophersen","sequence":"additional","affiliation":[{"name":"Centre for Immune Regulation and Department of Immunology, University of Oslo and Oslo University Hospital - Rikshospitalet 1 , 0372 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut E. 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