{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:15:10Z","timestamp":1772691310929,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2014,3,19]],"date-time":"2014-03-19T00:00:00Z","timestamp":1395187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>MiR-155 \u2212\/\u2212 mice are highly resistant to experimental autoimmune encephalomyelitis (EAE), while Pdcd1\u2212\/\u2212 mice develop a more severe form of the disease. To determine the conflicting roles of these two molecules in the disease, we generated miR-155\u2212\/\u2212Pdcd1\u2212\/\u2212 double knockout (DKO) mice. We found that ablation of programmed cell death protein 1 (PD-1) expression in miR-155-deficient mice restored the susceptibility to EAE. The increased severity of the disease in DKO mice was accompanied by an enhanced T-cell infiltration into the brain as well as an increased production of pro-inflammatory cytokines IFN-\u03b3 and IL-17. Furthermore, the major contribution of the DKO to EAE was T-cell intrinsic since adoptive transfer of CD4+ T cells from DKO donors promoted the disease in lymphopenic recipients. These results define PD-1 deficiency in miR-155\u2212\/\u2212 mice as a promoting factor of autoimmune inflammation by increasing antigen-driven T-cell expansion and infiltration.<\/jats:p>","DOI":"10.1093\/intimm\/dxu043","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T03:20:06Z","timestamp":1395285606000},"page":"407-415","source":"Crossref","is-referenced-by-count":17,"title":["PD-1 deletion restores susceptibility to experimental autoimmune encephalomyelitis in miR-155-deficient mice"],"prefix":"10.1093","volume":"26","author":[{"given":"Jinyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles 1 , Gosselies 1420 , Belgium"},{"name":"Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, Third Military Medical University 2 , Chongqing 400038 , People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel Y.","family":"Braun","sequence":"additional","affiliation":[{"name":"Institute for Medical Immunology, Universit\u00e9 Libre de Bruxelles 1 , Gosselies 1420 , Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,3,19]]},"reference":[{"key":"2022072023083808400_CIT0001","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nature07755","article-title":"A three-dimensional view of the molecular machinery of RNA interference","volume":"457","author":"Jinek","year":"2009","journal-title":"Nature"},{"key":"2022072023083808400_CIT0002","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1126\/science.1146067","article-title":"MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F","volume":"317","author":"Mathonnet","year":"2007","journal-title":"Science"},{"key":"2022072023083808400_CIT0003","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.immuni.2010.09.009","article-title":"MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development","volume":"33","author":"O\u2019Connell","year":"2010","journal-title":"Immunity"},{"key":"2022072023083808400_CIT0004","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.immuni.2008.11.010","article-title":"Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein","volume":"30","author":"Lu","year":"2009","journal-title":"Immunity"},{"key":"2022072023083808400_CIT0005","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1126\/science.1139253","article-title":"Requirement of bic\/microRNA-155 for normal immune function","volume":"316","author":"Rodriguez","year":"2007","journal-title":"Science"},{"key":"2022072023083808400_CIT0006","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.4049\/jimmunol.1101772","article-title":"MicroRNA-155 is essential for the T cell-mediated control of Helicobacter pylori infection and for the induction of chronic Gastritis and Colitis","volume":"187","author":"Oertli","year":"2011","journal-title":"J. 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