{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:00:00Z","timestamp":1760608800816},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:00:00Z","timestamp":1404345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The IgM-Fc receptor (Fc\u03bcR) is involved in IgM homeostasis as evidenced by increased pre-immune serum IgM and natural auto-antibodies of both IgM and IgG isotypes in Fcmr-deficient C57BL\/6 (B6) mice. To determine the impact of Fcmr-ablation on autoimmunity, we introduced the Fcmr null mutation onto the Fas-deficient autoimmune-prone B6.MRL Faslpr\/lpr mouse background (B6\/lpr). Both IgM and IgG auto-antibodies against dsDNA or chromatin appeared earlier in Fc\u03bcR(\u2212) B6\/lpr than Fc\u03bcR(+) B6\/lpr mice, but this difference became less pronounced with age. Splenic B2 cells, which were 2-fold elevated in Fc\u03bcR(+) B6\/lpr mice, were reduced to normal B6 levels in Fc\u03bcR(\u2212) B6\/lpr mice, whereas splenic B1 cells were comparable in both groups of B6\/lpr mice. By contrast, marginal zone (MZ) B cells were markedly reduced in Fc\u03bcR(\u2212) B6\/lpr mice compared with either Fc\u03bcR(+) B6\/lpr or wild type (WT) B6 mice. This reduction appeared to result from rapid differentiation of MZ B cells into plasma cells in the absence of Fc\u03bcR, as IgM antibody to a Smith (Sm) antigen, to which MZ B cells are known to preferentially respond, was greatly increased in both groups (B6\/lpr and B6) of Fc\u03bcR(\u2212) mice compared with Fc\u03bcR(+) B6\/lpr or B6 mice. Mott cells, aberrant plasma cells with intra-cytoplasmic inclusions, were also increased in the absence of Fc\u03bcR. Despite these abnormalities, the severity of renal pathology and function and survival were all indistinguishable between Fc\u03bcR(\u2212) and Fc\u03bcR(+) B6\/lpr mice. Collectively, these findings suggest that Fc\u03bcR plays important roles in the regulation of auto-antibody production, Mott cell formation and the differentiation of MZ B cells into plasma cells in B6.MRL Faslpr\/lpr mice.<\/jats:p>","DOI":"10.1093\/intimm\/dxu070","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T02:34:31Z","timestamp":1404441271000},"page":"659-672","source":"Crossref","is-referenced-by-count":21,"title":["Enhanced auto-antibody production and Mott cell formation in Fc\u03bcR-deficient autoimmune mice"],"prefix":"10.1093","volume":"26","author":[{"given":"Kazuhito","family":"Honjo","sequence":"first","affiliation":[{"name":"Department of Pathology 1 , , Birmingham, AL 35294 , USA"},{"name":"University of Alabama at Birmingham 1 , , Birmingham, AL 35294 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Kubagawa","sequence":"additional","affiliation":[{"name":"Department of Pathology 1 , , Birmingham, AL 35294 , USA"},{"name":"University of Alabama at Birmingham 1 , , Birmingham, AL 35294 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 2 , , , Tokyo 113-8421 , Japan"},{"name":"Division of Nephrology 2 , , , Tokyo 113-8421 , Japan"},{"name":"Juntendo University School of Medicine 2 , , , Tokyo 113-8421 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 2 , , , Tokyo 113-8421 , Japan"},{"name":"Division of Nephrology 2 , , , Tokyo 113-8421 , Japan"},{"name":"Juntendo University School of Medicine 2 , , , Tokyo 113-8421 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohno","sequence":"additional","affiliation":[{"name":"Laboratory for Intestinal Ecosystem 3 , , Yokohama 230-0045 , Japan"},{"name":"RIKEN Center for Integrative Medical Sciences 3 , , Yokohama 230-0045 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Pat","family":"Bucy","sequence":"additional","affiliation":[{"name":"Department of Pathology 1 , , Birmingham, AL 35294 , USA"},{"name":"University of Alabama at Birmingham 1 , , Birmingham, AL 35294 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Izui","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology 4 , , 1211 Geneva 4 , Switzerland"},{"name":"University of Geneva 4 , , 1211 Geneva 4 , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Kubagawa","sequence":"additional","affiliation":[{"name":"Department of Pathology 1 , , Birmingham, AL 35294 , USA"},{"name":"University of Alabama at Birmingham 1 , , Birmingham, AL 35294 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,7,3]]},"reference":[{"key":"2022073002595355800_CIT0001","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nri2849","article-title":"The importance of natural IgM: scavenger, protector and regulator","volume":"10","author":"Ehrenstein","year":"2010","journal-title":"Nat. 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