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CC chemokine receptor 8 (CCR8) is one such molecule, of which expression is up-regulated in inflammatory sites of ACD patients. In this study, we found that Ccr8\u2212\/\u2212 mice developed severer contact hypersensitivity (CHS) responses to 2,4-dinitrofluorobenzene, a murine model of ACD, compared with wild-type mice. T cells from Ccr8\u2212\/\u2212 mice showed enhanced proliferative recall responses and Th1 and Th17 cell populations were expanded in these mice. However, CHS responses were similar between SCID mice adoptively transferred with Ccr8\u2212\/\u2212 and wild-type T cells, suggesting that CCR8 in T cells is not responsible for the exacerbation of CHS. Notably, skin-resident dendritic cells (DCs), such as Langerhans cells and dermal DCs, and inflammatory DCs were highly accumulated in lymph nodes (LNs) of Ccr8\u2212\/\u2212 mice after sensitization. Consistent with this, Ccr8\u2212\/\u2212 antigen-presenting cells readily migrated from the skin to the draining LNs after sensitization. These observations suggest that CCR8 negatively regulates migration of cutaneous DCs from the skin to the draining LNs in CHS by keeping these cells in the skin.<\/jats:p>","DOI":"10.1093\/intimm\/dxu098","type":"journal-article","created":{"date-parts":[[2014,10,26]],"date-time":"2014-10-26T01:15:43Z","timestamp":1414286143000},"page":"169-181","source":"Crossref","is-referenced-by-count":21,"title":["CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes"],"prefix":"10.1093","volume":"27","author":[{"given":"Rikio","family":"Yabe","sequence":"first","affiliation":[{"name":"Center for Animal Disease Models, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science 1 , Noda, Chiba 278-0022 , Japan"},{"name":"Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, University of Tokyo (IMSUT) 2 , Minato-ku, Tokyo 108-8639 , Japan"},{"name":"Medical Mycology Research Center, Chiba University 3 , Inohana Chuo-ku, Chiba 260-8673 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Center for Animal Disease Models, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science 1 , Noda, Chiba 278-0022 , Japan"},{"name":"Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, University of Tokyo (IMSUT) 2 , Minato-ku, Tokyo 108-8639 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, University of Tokyo (IMSUT) 2 , Minato-ku, Tokyo 108-8639 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoe","family":"Azechi","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, University of Tokyo (IMSUT) 2 , Minato-ku, Tokyo 108-8639 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Il","family":"Choi","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, University of Tokyo (IMSUT) 2 , Minato-ku, Tokyo 108-8639 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuko","family":"Sudo","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, University of Tokyo (IMSUT) 2 , Minato-ku, Tokyo 108-8639 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Kubo","sequence":"additional","affiliation":[{"name":"Center for Animal Disease Models, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science 1 , Noda, Chiba 278-0022 , Japan"},{"name":"Center for 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Tokyo 113-8657 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Center for Animal Disease Models, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science 1 , Noda, Chiba 278-0022 , Japan"},{"name":"Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, University of Tokyo (IMSUT) 2 , Minato-ku, Tokyo 108-8639 , Japan"},{"name":"Medical Mycology Research Center, Chiba University 3 , Inohana Chuo-ku, Chiba 260-8673 , Japan"},{"name":"Core Research for Evolutional and Technology (CREST), Japan Science and Technology Agency 5 , Kawaguchi, Saitama 332-0012 , 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