{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:29:28Z","timestamp":1791221368027,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>If Bcl11b activity is compromised, CD4+CD8+ double-positive (DP) thymocytes produce a greatly increased fraction of innate CD8+ single-positive (SP) cells highly producing IFN-\u03b3, which are also increased in mice deficient of genes such as Itk, Id3 and NF-\u03baB1 that affect TCR signaling. Of interest, the increase in the former two is due to the bystander effect of IL-4 that is secreted by promyelocytic leukemia zinc finger-expressing NKT and \u03b3\u03b4T cells whereas the increase in the latter is cell intrinsic. Bcl11b zinc-finger proteins play key roles in T cell development and T cell-mediated immune response likely through TCR signaling. We examined thymocytes at and after the DP stage in Bcl11bF\/S826GCD4cre, Bcl11bF\/+CD4cre and Bcl11b+\/S826G mice, carrying the allele that substituted serine for glycine at the position of 826. Here we show that Bcl11b impairment leads to an increase in the population of TCR\u03b1\u03b2highCD44highCD122high innate CD8SP thymocytes, together with two different developmental abnormalities: impaired positive and negative selection accompanying a reduction in the number of CD8SP cells, and developmental arrest of NKT cells at multiple steps. The innate CD8SP thymocytes express Eomes and secrete IFN-\u03b3 after stimulation with PMA and ionomycin, and in this case their increase is not due to a bystander effect of IL-4 but cell intrinsic. Those results indicate that Bcl11b regulates development of different thymocyte subsets at multiple stages and prevents an excess of innate CD8SP thymocytes.<\/jats:p>","DOI":"10.1093\/intimm\/dxu104","type":"journal-article","created":{"date-parts":[[2014,11,25]],"date-time":"2014-11-25T02:15:03Z","timestamp":1416881703000},"page":"205-215","source":"Crossref","is-referenced-by-count":25,"title":["Bcl11b prevents the intrathymic development of innate CD8 T cells in a cell intrinsic manner"],"prefix":"10.1093","volume":"27","author":[{"given":"Satoshi","family":"Hirose","sequence":"first","affiliation":[{"name":"Division of Molecular Biology, Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Touma","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Niigata University, Niigata 950-2181, Japan 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rieka","family":"Go","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology, Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Katsuragi","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology, Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Sakuraba","sequence":"additional","affiliation":[{"name":"Mutagenesis and Genomics Team, RIKEN BioResource Center, Ibaragi 305-0074, Japan 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Gondo","sequence":"additional","affiliation":[{"name":"Mutagenesis and Genomics Team, RIKEN BioResource Center, Ibaragi 305-0074, Japan 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Abe","sequence":"additional","affiliation":[{"name":"Basic Neuroscience Branch, Brain Research Institute, Niigata University, Niigata 951-8510, Japan 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Sakimura","sequence":"additional","affiliation":[{"name":"Basic Neuroscience Branch, Brain Research Institute, Niigata University, Niigata 951-8510, Japan 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Mishima","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology, Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Kominami","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology, Department of Molecular Genetics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8510, Japan 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"2022071922582584600_CIT0001","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0952-7915(00)00208-9","article-title":"Signal strength in thymic selection and lineage commitment","volume":"13","author":"Hogquist","year":"2001","journal-title":"Curr. 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