{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:51:48Z","timestamp":1767844308837,"version":"3.49.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adenovirus vectors (Adv) elicit innate immune responses via several pattern-recognition receptors. Although it has been suggested that various Adv-induced mechanisms play important roles in the induction of innate immunity in vitro , the impacts of these mechanisms in vivo remain unclear. Viral nucleic acids elicit innate immune responses through the recognition of cytosolic nucleic acid sensors and transduce intracellular signals to TANK-binding kinase (TBK) 1. In this study, to determine the impacts of viral nucleic acids on innate immune responses in vivo , we administered transgene-expressing Adv to Tbk1 -deficient mice. The systemic Adv administration failed to induce type I interferons (type I IFNs) in the spleen, but not the liver, of Tbk1 -deficient mice, resulting in the increase of transgene-expressing cells in the spleen, but not the liver. Moreover, Adv failed to induce type I IFNs in the bone-marrow-derived dendritic cells, but not the mouse embryonic fibroblasts, from Tbk1 -deficient mice in vitro . These results support the idea that Adv elicit innate immunity in immune cells and non-immune cells in a TBK1-dependent and TBK1-independent manner, respectively.<\/jats:p>","DOI":"10.1093\/intimm\/dxv058","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T00:52:52Z","timestamp":1445475172000},"page":"105-115","source":"Crossref","is-referenced-by-count":13,"title":["TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector"],"prefix":"10.1093","volume":"28","author":[{"given":"Sayaka","family":"Tsuzuki","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University 1 , Osaka 565\u20130871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kawabata","sequence":"additional","affiliation":[{"name":"Laboratory of Stem Cell Regulation, National Institute of Biomedical Innovation, Health and Nutrition 2 , Osaka 567-0085 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken J.","family":"Ishii","sequence":"additional","affiliation":[{"name":"Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation, Health and Nutrition 4 , Osaka 567-0085 , Japan"},{"name":"Laboratory of Vaccine Science, World Premier International Immunology Frontier Research Center, Osaka University 5 , Osaka 565\u20130871 , Japan"},{"name":"Laboratory of Vaccine Design, National Institute of Biomedical Innovation, Health and Nutrition 6 , Osaka 567-0085 , Japan"},{"name":"Center for Drug Design Research, National Institute of Biomedical Innovation, Health and Nutrition 7 , Osaka 567-0085 , Japan"},{"name":"Department of Virology and Immunology, Graduate School of Medicine, Osaka University 8 , Osaka 565\u20130871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuo","family":"Akira","sequence":"additional","affiliation":[{"name":"Laboratory of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University 9 , Osaka 565\u20130871 , Japan"},{"name":"Department of Host Defense, The Research Institute for Microbial Diseases, Osaka University 10 , Osaka 565\u20130871 , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Mizuguchi","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University 1 , Osaka 565\u20130871 , Japan"},{"name":"iPS Cell-Based Research Project on Hepatic Toxicity and Metabolism, Graduate School of Pharmaceutical Sciences, Osaka University 11 , Osaka 565\u20130871 , Japan"},{"name":"Laboratory 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