{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:49:00Z","timestamp":1790232540798,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T00:00:00Z","timestamp":1445904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Modulation of TCR signaling upon ligand binding is achieved by changes in the equilibrium between TCR degradation, recycling and synthesis; surprisingly, the molecular mechanism of such an important process is not fully understood. Here, we describe the role of a new player in the mediation of TCR degradation: the endocytic adaptor Numb. Our data show that Numb inhibition leads to abnormal intracellular distribution and defective TCR degradation in mature T lymphocytes. In addition, we find that Numb simultaneously binds to both Cbl and a site within CD3\u03b5 that overlaps with the Nck binding site. As a result, Cbl couples specifically to the CD3\u03b5 chain to mediate TCR degradation. The present study unveils a novel role of Numb that lies at the heart of TCR signaling initiation and termination.<\/jats:p>","DOI":"10.1093\/intimm\/dxv060","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T01:53:39Z","timestamp":1446515619000},"page":"127-137","source":"Crossref","is-referenced-by-count":13,"title":["CD3\u03b5 recruits Numb to promote TCR degradation"],"prefix":"10.1093","volume":"28","author":[{"given":"Nadia","family":"Martin-Blanco","sequence":"first","affiliation":[{"name":"Instituto de Parasitolog\u00eda y Biomedicina, CSIC, P. T. Ciencias de la Salud 1 , 18100 Granada , Spain"},{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, CSIC, Universidad Aut\u00f3noma de Madrid, Cantoblanco 3 , Madrid 28049 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Jim\u00e9nez Teja","sequence":"additional","affiliation":[{"name":"Instituto de Parasitolog\u00eda y Biomedicina, CSIC, P. T. Ciencias de la Salud 1 , 18100 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Bretones","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular, Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-CSIC-SODERCAN 2 , Santander , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Borroto","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, CSIC, Universidad Aut\u00f3noma de Madrid, Cantoblanco 3 , Madrid 28049 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Caraballo","sequence":"additional","affiliation":[{"name":"Instituto de Parasitolog\u00eda y Biomedicina, CSIC, P. T. Ciencias de la Salud 1 , 18100 Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Screpanti","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pathology, Department of Experimental Medicine, Sapienza University of Rome 4 , Viale Regina Elena, 324, 00161 Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular, Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, Universidad de Cantabria-CSIC-SODERCAN 2 , Santander , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balbino","family":"Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Molecular Severo Ochoa, CSIC, Universidad Aut\u00f3noma de Madrid, Cantoblanco 3 , Madrid 28049 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Canelles","sequence":"additional","affiliation":[{"name":"Instituto de Parasitolog\u00eda y Biomedicina, CSIC, P. 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