{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T03:27:42Z","timestamp":1784431662350,"version":"3.55.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K06843"],"award-info":[{"award-number":["15K06843"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been reported that splenic immune responses play pivotal roles in the development of allergic diseases; however, the precise role of the spleen remains unclear. Herein, we demonstrated a novel role of the spleen in the pathogenesis of food allergy (FA). We found that mast cells (MCs) developed from progenitor cells present in spleen during an antigen-specific T-cell response in vitro. In a Th2 response-mediated FA model, significant expansion of MCs was also observed in spleen. The incidence of allergic diarrhea was profoundly reduced in splenectomized mice, whereas adoptive transfer of in vitro-induced splenic MCs into these mice restored allergic symptoms, suggesting that the splenic MCs functioned as the pathogenic cells in the development of FA. The in vitro-generated MCs required not only IL-3 but also IFN-\u03b3, and treatment of FA-induced mice with anti-IFN-\u03b3 antibody suppressed expansion of MCs in spleen as well as diarrhea development, highlighting that IFN-\u03b3 in the spleen orchestrated the development of FA, which was followed by a Th2 response in the local lesion. Overall, we propose that the role of the spleen in the development of FA is to provide a unique site where antigen-specific T cells induce development of pathogenic MCs.<\/jats:p>","DOI":"10.1093\/intimm\/dxx005","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T13:28:35Z","timestamp":1485782915000},"page":"31-45","source":"Crossref","is-referenced-by-count":31,"title":["The spleen is the site where mast cells are induced in the development of food allergy"],"prefix":"10.1093","volume":"29","author":[{"given":"Shota","family":"Toyoshima","sequence":"first","affiliation":[{"name":"Division of Immunobiology, Research Institute for Biomedical Sciences, Tokyo University of Science , Yamazaki 2669, Noda, Chiba 278-0022 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ei","family":"Wakamatsu","sequence":"additional","affiliation":[{"name":"Division of Immunobiology, Research Institute for Biomedical Sciences, Tokyo University of Science , Yamazaki 2669, Noda, Chiba 278-0022 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Pathology, Teikyo University Chiba Medical Center , Ichihara, Chiba 299-0111 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuuki","family":"Obata","sequence":"additional","affiliation":[{"name":"Division of Immunobiology, Research Institute for Biomedical Sciences, Tokyo University of Science , Yamazaki 2669, Noda, Chiba 278-0022 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Kurashima","sequence":"additional","affiliation":[{"name":"Division of Mucosal Immunology, Department of Microbiology and Immunology and"},{"name":"International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo , Tokyo 108-8639 , Japan"},{"name":"Department of Innovative Medicine, Graduate School of Medicine ,"},{"name":"Institute for Global Prominent Research and"},{"name":"Departments of Mucosal Immunology and Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kiyono","sequence":"additional","affiliation":[{"name":"Division of Mucosal Immunology, Department of Microbiology and Immunology and"},{"name":"International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo , Tokyo 108-8639 , Japan"},{"name":"Departments of Mucosal Immunology and Immunology, Graduate School of Medicine, Chiba University , Chiba 260-8670 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Immunobiology, Research Institute for Biomedical Sciences, Tokyo University of Science , Yamazaki 2669, Noda, Chiba 278-0022 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,2,8]]},"reference":[{"key":"2022082713092346200_CIT0001","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jaci.2010.10.008","article-title":"Guidelines for the Diagnosis and Management of Food Allergy in the United States: summary of the NIAID-Sponsored Expert Panel Report","volume":"126","author":"Boyce","year":"2010","journal-title":"J. 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