{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:31:05Z","timestamp":1772796665873,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2017,11,7]],"date-time":"2017-11-07T00:00:00Z","timestamp":1510012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004442","name":"National Science Centre","doi-asserted-by":"crossref","award":["NN402420738"],"award-info":[{"award-number":["NN402420738"]}],"id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004442","name":"National Science Centre","doi-asserted-by":"crossref","award":["NN402562440"],"award-info":[{"award-number":["NN402562440"]}],"id":[{"id":"10.13039\/501100004442","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005632","name":"National Centre for Research and Development","doi-asserted-by":"crossref","award":["STRATEGMED1\/233368\/1\/NCBR\/2014"],"award-info":[{"award-number":["STRATEGMED1\/233368\/1\/NCBR\/2014"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Human cytomegalovirus (HCMV) is considered to be a major pathogen that affects the outcome of solid organ transplantation (TX). Both recipient and donor may be HCMV positive, therefore HCMV re-infection is possible after TX. However, little is known how cytomegalovirus (CMV) transmitted from an infected donor to an infected recipient modulates the recipient\u2019s already suppressed immunity, and what the clinical consequences are. To investigate these issues, 52 kidney recipients were followed up for 2 years after TX. T, B and natural killer (NK) lymphocytes, naive and memory T subsets, CD28 expression, relative telomere length, CMV-specific lymphocytes and serum cytokines were measured several times post-TX. Patients were monitored for signs of CMV viremia and other infections. The most important observation was that CMV-specific lymphocytes expand vastly in HCMV-infected recipients who received kidneys from infected donors, in comparison with uninfected donors. Despite this, a higher rate of HCMV viremia was found. Immune deterioration was confirmed by an increased number of CD28-negative T lymphocytes, inverted CD4\/CD8 index and shortened telomeres. This was superior in HCMV-infected recipients transplanted from infected donors, when compared with uninfected. In conclusion, CMV alters the immune system in kidney transplant recipients and promotes immune exhaustion.<\/jats:p>","DOI":"10.1093\/intimm\/dxx062","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T12:14:17Z","timestamp":1509624857000},"page":"541-549","source":"Crossref","is-referenced-by-count":17,"title":["Impact of donor and recipient human cytomegalovirus status on kidney transplantation"],"prefix":"10.1093","volume":"29","author":[{"given":"Maciej","family":"Zieli\u0144ski","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Transplantology, Medical University of Gda\u0144sk, Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Tarasewicz","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gda\u0144sk, Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Zieli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Transplantology, Medical University of Gda\u0144sk, Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Jankowska","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gda\u0144sk, Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gra\u017cyna","family":"Moszkowska","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Transplantology, Medical University of Gda\u0144sk, Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicja","family":"D\u0119bska-\u015alizie\u0144","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gda\u0144sk, Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boles\u0142aw","family":"Rutkowski","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gda\u0144sk, Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Trzonkowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Transplantology, Medical University of Gda\u0144sk, Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,11,7]]},"reference":[{"key":"2022082522472196300_CIT0001","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/01.TP.0000148239.00384.F0","article-title":"Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients","volume":"79","author":"Rowshani","year":"2005","journal-title":"Transplantation"},{"key":"2022082522472196300_CIT0002","doi-asserted-by":"crossref","first-page":"28","DOI":"10.12703\/P6-28","article-title":"Cell-mediated immunity to human CMV infection: a brief overview","volume":"6","author":"Terrazzini","year":"2014","journal-title":"F1000Prime Rep"},{"key":"2022082522472196300_CIT0003","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.virusres.2010.09.010","article-title":"Role of CMV in immune senescence","volume":"157","author":"Pawelec","year":"2011","journal-title":"Virus Res"},{"key":"2022082522472196300_CIT0004","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nm0402-379","article-title":"Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections","volume":"8","author":"Appay","year":"2002","journal-title":"Nat. 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