{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:44:20Z","timestamp":1773279860411,"version":"3.50.1"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of allergic diseases, which increased to epidemic proportions in developed countries over the last few decades, has been correlated with altered gut microbiota colonization. Although probiotics may play a critical role in the restoration of gut homeostasis, their efficiency in the control of allergy is controversial. Here, we aimed to investigate the effects of probiotic treatment initiated at neonatal or adult ages on the suppression of experimental ovalbumin (OVA)-induced asthma. Neonatal or adult mice were orally treated with probiotic bacteria and subjected to OVA-induced allergy. Asthma-like symptoms, microbiota composition and frequencies of the total CD4+ T lymphocytes and CD4+Foxp3+ regulatory T (Treg) cells were evaluated in both groups. Probiotic administration to neonates, but not to adults, was necessary and sufficient for the absolute prevention of experimental allergen-induced sensitization. The neonatally acquired tolerance, transferrable to probiotic-untreated adult recipients by splenic cells from tolerant donors, was associated with modulation of gut bacterial composition, augmented levels of cecum butyrate and selective accumulation of Treg cells in the airways. Our findings reveal that a cross-talk between a healthy microbiota and qualitative features inherent to neonatal T cells, especially in the Treg cell subset, might support the beneficial effect of perinatal exposure to probiotic bacteria on the development of long-term tolerance to allergens.<\/jats:p>","DOI":"10.1093\/intimm\/dxy011","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T12:09:23Z","timestamp":1517573363000},"page":"155-169","source":"Crossref","is-referenced-by-count":19,"title":["Probiotic treatment during neonatal age provides optimal protection against experimental asthma through the modulation of microbiota and T cells"],"prefix":"10.1093","volume":"30","author":[{"given":"Caroline Fraga","family":"Nunes","sequence":"first","affiliation":[{"name":"Departamento de Imunologia, Instituto de Microbiologia Paulo de Go\u00e9s (IMPG) \u2013 Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"},{"name":"Departamento de Imunobiologia, Instituto de Biologia \u2013 Universidade Federal Fluminense, Niter\u00f3i \u2013 RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeane S","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Microbiologia Paulo de Go\u00e9s (IMPG) \u2013 Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"},{"name":"Departamento de Imunobiologia, Instituto de Biologia \u2013 Universidade Federal Fluminense, Niter\u00f3i \u2013 RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Henrique Oliveira","family":"Vianna","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Microbiologia Paulo de Go\u00e9s (IMPG) \u2013 Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca Torres","family":"Ciambarella","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o \u2013 Instituto Oswaldo Cruz \u2013 FIOCRUZ, Rio de Janeiro \u2013 RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia Machado","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inflama\u00e7\u00e3o \u2013 Instituto Oswaldo Cruz \u2013 FIOCRUZ, Rio de Janeiro \u2013 RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla Rodrigues","family":"Miranda","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia \u2013 Universidade Federal do Rio de Janeiro, Rio de Janeiro\/Campus Maca\u00e9, Maca\u00e9 \u2013 RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro Ara\u00fajo","family":"Lobo","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia M\u00e9dica, Instituto de Microbiologia Paulo de Go\u00e9s (IMPG) \u2013 Universidade Federal do Rio de Janeiro, Rio de Janeiro \u2013 RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina Maria Cavalcanti Pillotto","family":"Domingues","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia M\u00e9dica, Instituto de Microbiologia Paulo de Go\u00e9s (IMPG) \u2013 Universidade Federal do Rio de Janeiro, Rio de Janeiro \u2013 RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mileane","family":"Busch","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u00edmica M\u00e9dica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro \u2013 RJ, Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Entomologia Molecular, INCT-EM, Rio de Janeiro - RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia Correa","family":"Atella","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u00edmica M\u00e9dica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro \u2013 RJ, Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Entomologia Molecular, INCT-EM, Rio de Janeiro - RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Macedo","family":"Vale","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunorreceptores e Sinaliza\u00e7\u00e3o, Instituto de Biof\u00edsica Carlos Chagas Filho \u2013 Universidade Federal do Rio de Janeiro, Rio de Janeiro \u2013 RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Bellio","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Microbiologia Paulo de Go\u00e9s (IMPG) \u2013 Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"N\u00f3brega","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Microbiologia Paulo de Go\u00e9s (IMPG) \u2013 Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7574-2613","authenticated-orcid":false,"given":"F\u00e1bio B","family":"Canto","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia, Instituto de Microbiologia Paulo de Go\u00e9s (IMPG) \u2013 Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"},{"name":"Departamento de Imunobiologia, Instituto de Biologia \u2013 Universidade Federal Fluminense, Niter\u00f3i \u2013 RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Fucs","sequence":"additional","affiliation":[{"name":"Departamento de Imunobiologia, Instituto de Biologia \u2013 Universidade Federal Fluminense, Niter\u00f3i \u2013 RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,2,6]]},"reference":[{"key":"2022071302391742800_CIT0001","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1056\/NEJMra054308","article-title":"The asthma epidemic","volume":"355","author":"Eder","year":"2006","journal-title":"N. 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