{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T09:26:56Z","timestamp":1740130016272,"version":"3.37.3"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"JSPS KAKENHI","award":["JP15H05703","JP16H05202"],"award-info":[{"award-number":["JP15H05703","JP16H05202"]}]},{"name":"Practical Research Project for Rare\/Intractable Diseases","award":["JP17ek0109106"],"award-info":[{"award-number":["JP17ek0109106"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["26-105","29-1001"],"award-info":[{"award-number":["26-105","29-1001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003837","name":"Ichiro Kanehara Foundation","doi-asserted-by":"crossref","award":["29-23"],"award-info":[{"award-number":["29-23"]}],"id":[{"id":"10.13039\/501100003837","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\u03b3\u03b4T cells develop in the thymus and play important roles in protection against infection and tumor development, but the mechanisms by which the thymic microenvironment supports \u03b3\u03b4T cell differentiation remain largely unclear. Skint1, a B7-related protein expressed in thymic epithelial cells, was shown to be essential for the development of mouse V\u03b35V\u03b41 \u03b3\u03b4T cells. The Skint family in mouse consists of 11 members, Skint1-11. Here we generated mutant mice lacking the entire genomic region that contains all of the Skint genes. These mice exhibited a marked reduction of V\u03b35V\u03b41 \u03b3\u03b4T cells in the thymus and skin, but surprisingly, had normal development of other \u03b3\u03b4T cell subsets and leukocytes including \u03b1\u03b2T, B and myeloid cells. This phenotype is essentially identical to that of Skint1-deficient mice. These results indicate that the Skint family exerts an exclusive function in regulating the development of V\u03b35V\u03b41 \u03b3\u03b4T cells and is dispensable for development of other leukocytes.<\/jats:p>","DOI":"10.1093\/intimm\/dxy030","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T06:44:47Z","timestamp":1524638687000},"page":"301-309","source":"Crossref","is-referenced-by-count":10,"title":["Mice lacking all of the <i>Skint<\/i> family genes"],"prefix":"10.1093","volume":"30","author":[{"given":"Tomoya","family":"Narita","sequence":"first","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Nitta","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Okamura","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Medicine, Research Institute, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan"},{"name":"Section of Animal Models, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takayanagi","sequence":"additional","affiliation":[{"name":"Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"2022071011254584600_CIT0001","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nri3667","article-title":"Positive and negative selection of the T cell repertoire: what thymocytes see (and don\u2019t see)","volume":"14","author":"Klein","year":"2014","journal-title":"Nat. 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