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Studies of gene-deficient mice, in which each immunoproteasomal subunit was affected, have demonstrated that dysfunction of immunoproteasomes leads to immunodeficiency, i.e. reduced expression of MHC class I and attenuation of CD8 T-cell responses. Recent studies, however, have uncovered a new type of autoinflammatory syndrome characterized by fever, nodular erythema and progressive partial lipodystrophy that is caused by genetic mutations in immunoproteasome subunits. These mutations disturbed the assembly of immunoproteasomes, which led to reduced proteasomal activity and thus accumulation of ubiquitin-coupled proteins. Those findings suggest that immunoproteasomes function as anti-inflammatory machinery in humans. The discovery of a new type of autoinflammatory syndrome caused by dysregulated immunoproteasomes provides novel insights into the important roles of immunoproteasomes in inflammation as well as the spectrum of autoinflammatory diseases.<\/jats:p>","DOI":"10.1093\/intimm\/dxy059","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T12:28:54Z","timestamp":1535632134000},"page":"631-637","source":"Crossref","is-referenced-by-count":8,"title":["Dysregulation of immunoproteasomes in autoinflammatory syndromes"],"prefix":"10.1093","volume":"31","author":[{"given":"Koji","family":"Yasutomo","sequence":"first","affiliation":[{"name":"Department of Immunology & Parasitology, Graduate School of Medicine, Tokushima University , Kuramoto, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,8,31]]},"reference":[{"key":"2022071007560081400_CIT0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coi.2009.02.001","article-title":"Innate resistance and inflammation","volume":"21","author":"Gordon","year":"2009","journal-title":"Curr. 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