{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T17:30:08Z","timestamp":1792949408775,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T00:00:00Z","timestamp":1536969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"AMED-CREST"},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"crossref","award":["18059042"],"award-info":[{"award-number":["18059042"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health, Labour and Welfare of Japan"},{"name":"JSPS"},{"name":"MEXT\/JPS KAKENHI","award":["16H06958"],"award-info":[{"award-number":["16H06958"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,6]]},"DOI":"10.1093\/intimm\/dxy061","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T07:45:40Z","timestamp":1536738340000},"page":"33-40","source":"Crossref","is-referenced-by-count":65,"title":["Eosinophil-derived neurotoxin enhances airway remodeling in eosinophilic chronic rhinosinusitis and correlates with disease severity"],"prefix":"10.1093","volume":"31","author":[{"given":"Takeshi","family":"Tsuda","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Nishide","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitomo","family":"Hayama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nojima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Yamadaoka, Suita, Osaka, Japan"},{"name":"Department of Pathology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyota","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Okuzaki","sequence":"additional","affiliation":[{"name":"Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhei","family":"Kinehara","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Obata","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Osaka Rosai Hospital, Nagasone-cho, Sakai, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Akazawa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Shikina","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Department of Otolaryngology, Ikeda Municipal Hospital, Jyonan, Ikeda, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Hayama","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Inohara","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kumanogoh","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka, Japan"},{"name":"Laboratory of Immunopathology, World Premier International Immunology Frontier Research Center, Yamadaoka, Suita, Osaka, Japan"},{"name":"The Institute for Open and Transdisciplinary Research Initiatives (OTRI), 2-2 Yamadaoka, Suita, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,9,15]]},"reference":[{"key":"key\n\t\t\t\t2019020608493764900_CIT0001","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.jaci.2013.02.036","article-title":"Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology","volume":"131","author":"Akdis","year":"2013","journal-title":"J. Allergy Clin. Immunol"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino50E2","article-title":"European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0003","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/all.12644","article-title":"Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study","volume":"70","author":"Tokunaga","year":"2015","journal-title":"Allergy"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0004","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.jaci.2006.09.005","article-title":"Rhinosinusitis: developing guidance for clinical trials","volume":"118","author":"Meltzer","year":"2006","journal-title":"J. Allergy Clin. Immunol"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0005","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2332\/allergolint.10-RAI-0231","article-title":"Eosinophilic chronic rhinosinusitis in Japan","volume":"59","author":"Ishitoya","year":"2010","journal-title":"Allergol. Int"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0006","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jaci.2003.08.009","article-title":"Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma","volume":"112","author":"Ponikau","year":"2003","journal-title":"J Allergy Clin. Immunol"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0007","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s11882-007-0073-4","article-title":"Inflammatory mechanisms and remodeling in chronic rhinosinusitis and nasal polyps","volume":"7","author":"Pawankar","year":"2007","journal-title":"Curr. Allergy Asthma Rep"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0008","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1189\/jlb.0108058","article-title":"Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentially","volume":"85","author":"Spencer","year":"2009","journal-title":"J. Leukoc. Biol"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0009","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1398-9995.2003.00442.x","article-title":"Eosinophils: \u2018new\u2019 roles for \u2018old\u2019 cells","volume":"59","author":"Munitz","year":"2004","journal-title":"Allergy"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0010","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1086\/515322","article-title":"Recombinant human eosinophil-derived neurotoxin\/RNase 2 functions as an effective antiviral agent against respiratory syncytial virus","volume":"177","author":"Domachowske","year":"1998","journal-title":"J. Infect. Dis"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0011","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.4049\/jimmunol.177.7.4861","article-title":"Eosinophil-derived cationic proteins activate the synthesis of remodeling factors by airway epithelial cells","volume":"177","author":"P\u00e9gorier","year":"2006","journal-title":"J. Immunol"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0012","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1073\/pnas.83.10.3146","article-title":"Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease","volume":"83","author":"Gleich","year":"1986","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0013","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.2500\/aap.2015.36.3884","article-title":"Serum eosinophil-derived neurotoxin: correlation with persistent airflow limitation in adults with house-dust mite allergic asthma","volume":"36","author":"Gon","year":"2015","journal-title":"Allergy Asthma Proc"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0014","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0923-1811(00)00151-1","article-title":"Serum eosinophil derived neurotoxin may reflect more strongly disease severity in childhood atopic dermatitis than eosinophil cationic protein","volume":"26","author":"Taniuchi","year":"2001","journal-title":"J. Dermatol. Sci"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0015","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.cgh.2006.08.013","article-title":"Potential of blood eosinophils, eosinophil-derived neurotoxin, and eotaxin-3 as biomarkers of eosinophilic esophagitis","volume":"4","author":"Konikoff","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0016","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.alit.2016.05.008","article-title":"Utility of serum eosinophil-derived neurotoxin (EDN) measurement by ELISA in young children with asthma","volume":"66","author":"Kim","year":"2017","journal-title":"Allergol. Int"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0017","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1440-1592.2004.00357.x","article-title":"Concentrations of eosinophil-derived neurotoxin in the blood and urine of patients with allergic diseases","volume":"53","author":"Morioka","year":"2004","journal-title":"Allergol. Int"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0018","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00408-006-0054-8","article-title":"Serum eosinophil-derived neurotoxin (EDN) in diagnosis and evaluation of severity and bronchial hyperresponsiveness in childhood asthma","volume":"185","author":"Kim","year":"2007","journal-title":"Lung"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0019","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.anai.2017.06.022","article-title":"Eosinophil-derived neurotoxin as a biomarker for disease severity and relapse in recalcitrant atopic dermatitis","volume":"119","author":"Kim","year":"2017","journal-title":"Ann. Allergy Asthma Immunol"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0020","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/alr.21687","article-title":"A pilot study of symptom profiles from a polyp vs an eosinophilic-based classification of chronic rhinosinusitis","volume":"6","author":"Thompson","year":"2016","journal-title":"Int. Forum Allergy Rhinol"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0021","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/intimm\/dxx045","article-title":"Antibody therapy for the management of severe asthma with eosinophilic inflammation","volume":"29","author":"Ohta","year":"2017","journal-title":"Int. Immunol"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0022","doi-asserted-by":"crossref","first-page":"642","DOI":"10.4049\/jimmunol.144.2.642","article-title":"Regulatory effect of cytokines on eosinophil degranulation","volume":"144","author":"Fujisawa","year":"1990","journal-title":"J. Immunol"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0023","doi-asserted-by":"crossref","first-page":"629","DOI":"10.4049\/jimmunol.149.2.629","article-title":"Release of granule proteins from eosinophils cultured with IL-5","volume":"149","author":"Kita","year":"1992","journal-title":"J. Immunol"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0024","doi-asserted-by":"crossref","first-page":"6134","DOI":"10.4049\/jimmunol.173.10.6134","article-title":"Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation","volume":"173","author":"Yang","year":"2004","journal-title":"J. Immunol"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0025","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1182\/blood-2003-01-0151","article-title":"Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells","volume":"102","author":"Yang","year":"2003","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0026","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1084\/jem.20062027","article-title":"Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses","volume":"205","author":"Yang","year":"2008","journal-title":"J. Exp. Med"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0027","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1074\/jbc.M107611200","article-title":"Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration","volume":"277","author":"Mohan","year":"2002","journal-title":"J. Biol. Chem"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0028","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1053\/rmed.2001.1162","article-title":"Expression of matrix metalloproteinases MMP-9 within the airways in asthma","volume":"97","author":"Han","year":"2003","journal-title":"Respir. Med"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0029","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1398-9995.2006.01255.x","article-title":"Relationship between matrix metalloproteinases MMP-2, MMP-9, tissue inhibitor of matrix metalloproteinases-1 and IL-5, IL-8 in nasal polyps","volume":"62","author":"Chen","year":"2007","journal-title":"Allergy"},{"key":"key\n\t\t\t\t2019020608493764900_CIT0030","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1046\/j.1398-9995.2003.00364.x","article-title":"Matrix metalloproteinases MMP-7, MMP-9 and their tissue inhibitor TIMP-1: expression in chronic sinusitis vs nasal polyposis","volume":"59","author":"Watelet","year":"2004","journal-title":"Allergy"}],"container-title":["International Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/intimm\/article-pdf\/31\/1\/33\/27716319\/dxy061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T21:52:03Z","timestamp":1693864323000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/intimm\/article\/31\/1\/33\/5098282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,15]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,9,15]]},"published-print":{"date-parts":[[2019,2,6]]}},"URL":"https:\/\/doi.org\/10.1093\/intimm\/dxy061","relation":{},"ISSN":["0953-8178","1460-2377"],"issn-type":[{"value":"0953-8178","type":"print"},{"value":"1460-2377","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2018,9,15]]}}}