{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:56:40Z","timestamp":1788058600523,"version":"build-2784847793"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Infectious Diseases Research","award":["2008ZX10002002"],"award-info":[{"award-number":["2008ZX10002002"]}]},{"name":"Infectious Diseases Research","award":["2012ZX10002-006-002-003"],"award-info":[{"award-number":["2012ZX10002-006-002-003"]}]},{"name":"New Drug Research & Development","award":["2009ZX0913-710"],"award-info":[{"award-number":["2009ZX0913-710"]}]},{"name":"New Drug Research & Development","award":["2011AA02A11"],"award-info":[{"award-number":["2011AA02A11"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30571650"],"award-info":[{"award-number":["30571650"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31370927"],"award-info":[{"award-number":["31370927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Commission of Shanghai","award":["13431900602"],"award-info":[{"award-number":["13431900602"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The induction of a dominant Th2-type response is the main cause of harmful inflammation in respiratory syncytial virus (RSV) vaccine trials. A balanced Th1 versus Th2 immune response is needed for a safe and effective RSV vaccine. In this study, we evaluated the potential of a recombinant protein SBP-FG as a vaccine candidate with the main focus on shifting the harmful Th2 response to a Th1 response. SBP-FG consists of epitopes from RSV fusion (F) and attachment (G) proteins conjugated to the N-terminus of HBsAg-binding protein (SBP). SBP-FG induced significantly stronger immune responses assessed at the level of total IgG, IgA and neutralizing antibodies as compared with formalin-inactivated RSV (FI-RSV) and live RSV. Analysis of IgG isotypes, lung cytokines and T helper cells showed that SBP-FG induced a dominant Th1-type response. Further, SBP-FG immunized mice showed significantly reduced lung eosinophilia, reduced viral multiplication in lungs after challenge infection and provided protection against RSV infection. These results suggest that SBP-FG can be developed into a safe and effective vaccine against RSV. However, more studies are required to further evaluate SBP-FG as a potent vaccine candidate against RSV.<\/jats:p>","DOI":"10.1093\/intimm\/dxy078","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T02:13:09Z","timestamp":1542420789000},"page":"199-209","source":"Crossref","is-referenced-by-count":6,"title":["Respiratory syncytial virus F and G protein core fragments fused to HBsAg-binding protein (SBP) induce a Th1-dominant immune response without vaccine-enhanced disease"],"prefix":"10.1093","volume":"31","author":[{"given":"Inam Ullah","family":"Khan","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Immunology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farooq","family":"Ahmad","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Metal Matrix Composites and Shanghai Center for System Biomedicine, Shanghai Jiaotong University, Minhang, Shanghai, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuren","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Molecular Virology of the Ministry of Health and the Ministry of Education, Shanghai Medical College, Fudan University, Shanghai, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Lu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xie","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naishuo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"2022071819581063800_CIT0001","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.virol.2014.12.004","article-title":"Recombinant influenza virus carrying the conserved domain of respiratory syncytial virus (RSV) G protein confers protection against RSV without inflammatory disease","volume":"476","author":"Lee","year":"2015","journal-title":"Virology"},{"key":"2022071819581063800_CIT0002","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/icb.2009.115","article-title":"Eosinophils and Th2 immunity: contemporary insights","volume":"88","author":"Spencer","year":"2010","journal-title":"Immunol. 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