{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:19:59Z","timestamp":1787851199080,"version":"build-2784847793"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Japanese Grant-in-Aid for Scientific Research","award":["26293083"],"award-info":[{"award-number":["26293083"]}]},{"name":"Japanese Grant-in-Aid for Scientific Research","award":["16K15253"],"award-info":[{"award-number":["16K15253"]}]},{"name":"Japanese Grant-in-Aid for Scientific Research","award":["24117706"],"award-info":[{"award-number":["24117706"]}]},{"name":"Japanese Grant-in-Aid for Scientific Research","award":["25670189"],"award-info":[{"award-number":["25670189"]}]},{"name":"Japanese Grant-in-Aid for Scientific Research","award":["18H04856"],"award-info":[{"award-number":["18H04856"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Toll-like receptor 7 (TLR7) and type I interferons (IFN-1) are essential for the development of systemic lupus erythematosus (SLE) models such as BXSB.Yaa and 2,6,10,14-tetramethyl-pentadecane (TMPD)-induced experimental lupus. However, the mechanism underlying the development of SLE remains undefined. We report a requirement for ADP-ribosylation factor-like 8b (Arl8b) for TLR7-dependent IFN-1 production in plasmacytoid dendritic cells (pDCs). We analyzed whether Arl8b plays a role in two SLE models by comparing wild-type and Arl8b-deficient Arl8b GeneTrap (Arl8bGt\/Gt) mice. We found that BXSB.Yaa Arl8bGt\/Gt mice showed none of the abnormalities characterized in BXSB.Yaa mice. TMPD treatment of Arl8bGt\/Gt mice significantly inhibited the development of SLE. pDCs were required for TMPD-induced peritonitis. Our data demonstrate that Arl8b contributes to disease pathogenesis in two SLE models via IFN-1-dependent and -independent mechanisms and suggest that Arl8b is an attractive new target for therapeutic intervention in SLE.<\/jats:p>","DOI":"10.1093\/intimm\/dxy084","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T12:09:56Z","timestamp":1544184596000},"page":"225-237","source":"Crossref","is-referenced-by-count":1,"title":["ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus"],"prefix":"10.1093","volume":"31","author":[{"given":"Shin-Ichiroh","family":"Saitoh","sequence":"first","affiliation":[{"name":"Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minatoku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko Mori","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minatoku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kontani","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuaki","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan"},{"name":"Japan Agency for Medical Research and Development (AMED), Chiyoda-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Miyake","sequence":"additional","affiliation":[{"name":"Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minatoku, Tokyo, Japan"},{"name":"Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"2022071819581236900_CIT0001","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1056\/NEJMoa021933","article-title":"Development of autoantibodies before the clinical onset of systemic lupus erythematosus","volume":"349","author":"Arbuckle","year":"2003","journal-title":"N. 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