{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T23:02:27Z","timestamp":1791759747091,"version":"4.3.4"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T00:00:00Z","timestamp":1554336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["04435"],"award-info":[{"award-number":["04435"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Streptococcus suis serotype 2 is an important porcine bacterial pathogen and a zoonotic agent responsible for sudden death, septic shock and meningitis, with exacerbated inflammation being a hallmark of the systemic and central nervous system (CNS) infections. However, S. suis serotype 2 strains are genetically and phenotypically heterogeneous, being composed of a multitude of sequence types (STs) whose virulence greatly varies. Yet, most studies have used \u2018classical\u2019 virulent Eurasian ST1 or ST7 strains, even though ST25 and ST28 strains account for most isolates in North America. While recognition of S. suis by innate immune cells has been associated with the myeloid differentiation primary response 88 (MyD88)-dependent Toll-like receptor (TLR) pathway in vitro, particularly surface-associated TLR2, little information is available regarding its role in vivo. This study demonstrates for the first time a differential role of MyD88 signaling in S. suis-induced systemic and CNS diseases, regardless of strain background diversity. The MyD88-dependent pathway is critical for the development of systemic disease via its role in inflammation, which subsequently controls bacterial burden. However, and differently from what has been described in vitro, TLR2 and TLR4 individually do not contribute to systemic disease, suggesting possible compensation in their absence and\/or a collaborative role with other MyD88-dependent TLRs. On the other hand, CNS disease does not necessarily require MyD88 signaling and, consequently, neither TLR2 nor TLR4, suggesting a partial implication of other pathways. Finally, regardless of its notable heterogeneity, recognition of S. suis serotype 2 appears to be similar, indicating that recognized components are conserved motifs.<\/jats:p>","DOI":"10.1093\/intimm\/dxz033","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T20:13:08Z","timestamp":1553890388000},"page":"697-714","source":"Crossref","is-referenced-by-count":11,"title":["Differential role of MyD88 signaling in <i>Streptococcus suis<\/i> serotype 2-induced systemic and central nervous system diseases"],"prefix":"10.1093","volume":"31","author":[{"given":"Jean-Philippe","family":"Auger","sequence":"first","affiliation":[{"name":"Research Group on Infectious Diseases in Production Animals (GREMIP) and Swine and Poultry Infectious Disease Research Center (CRIPA) , Saint-Hyacinthe, Quebec, Canada"},{"name":"Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal , Saint-Hyacinthe, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Odile","family":"Benoit-Biancamano","sequence":"additional","affiliation":[{"name":"Research Group on Infectious Diseases in Production Animals (GREMIP) and Swine and Poultry Infectious Disease Research Center (CRIPA) , Saint-Hyacinthe, Quebec, Canada"},{"name":"Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal , Saint-Hyacinthe, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"B\u00e9dard","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal , Saint-Hyacinthe, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Segura","sequence":"additional","affiliation":[{"name":"Research Group on Infectious Diseases in Production Animals (GREMIP) and Swine and Poultry Infectious Disease Research Center (CRIPA) , Saint-Hyacinthe, Quebec, Canada"},{"name":"Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal , Saint-Hyacinthe, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Gottschalk","sequence":"additional","affiliation":[{"name":"Research Group on Infectious Diseases in Production Animals (GREMIP) and Swine and Poultry Infectious Disease Research Center (CRIPA) , Saint-Hyacinthe, Quebec, Canada"},{"name":"Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University of Montreal , Saint-Hyacinthe, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,4]]},"reference":[{"key":"2022071009271408200_CIT0001","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2217\/fmb.10.2","article-title":"Streptococcus suis: a new emerging or an old neglected zoonotic pathogen?","volume":"5","author":"Gottschalk","year":"2010","journal-title":"Future Microbiol"},{"key":"2022071009271408200_CIT0002","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1086\/596763","article-title":"Streptococcus suis: an emerging human pathogen","volume":"48","author":"Wertheim","year":"2009","journal-title":"Clin. Infect. Dis"},{"key":"2022071009271408200_CIT0003","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.4049\/jimmunol.179.3.1842","article-title":"Streptococcus suis serotype 2, an important swine and human pathogen, induces strong systemic and cerebral inflammatory responses in a mouse model of infection","volume":"179","author":"Dom\u00ednguez-Punaro","year":"2007","journal-title":"J. Immunol"},{"key":"2022071009271408200_CIT0004","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/pathogens5030048","article-title":"Virulence studies of different sequence types and geographical origins of Streptococcus suis serotype 2 in a mouse model of infection","volume":"5","author":"Auger","year":"2016","journal-title":"Pathogens"},{"key":"2022071009271408200_CIT0005","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1038\/emi.2014.45","article-title":"Streptococcus suis, an important pig pathogen and emerging zoonotic agent-an update on the worldwide distribution based on serotyping and sequence typing","volume":"3","author":"Goyette-Desjardins","year":"2014","journal-title":"Emerg. Microbes Infect"},{"key":"2022071009271408200_CIT0006","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1128\/JCM.40.10.3671-3680.2002","article-title":"Development of a multilocus sequence typing scheme for the pig pathogen Streptococcus suis: identification of virulent clones and potential capsular serotype exchange","volume":"40","author":"King","year":"2002","journal-title":"J. Clin. Microbiol"},{"key":"2022071009271408200_CIT0007","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1128\/IAI.01317-12","article-title":"Exacerbated type II interferon response drives hypervirulence and toxic shock by an emergent epidemic strain of Streptococcus suis","volume":"81","author":"Lachance","year":"2013","journal-title":"Infect. Immun"},{"key":"2022071009271408200_CIT0008","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.3389\/fimmu.2017.01039","article-title":"Type I interferon induced by streptococcus suis Serotype 2 is strain-dependent and may be beneficial for host survival","volume":"8","author":"Auger","year":"2017","journal-title":"Front. Immunol"},{"key":"2022071009271408200_CIT0009","doi-asserted-by":"crossref","first-page":"e87866","DOI":"10.1371\/journal.pone.0087866","article-title":"Comparative genomic hybridization identifies virulence differences in Streptococcus suis","volume":"9","author":"Zheng","year":"2014","journal-title":"PLoS One"},{"key":"2022071009271408200_CIT0010","first-page":"236","article-title":"Dilemma of virulence of Streptococcus suis: Canadian isolate 89-1591 characterized as a virulent strain using a standardized experimental model in pigs","volume":"69","author":"Berthelot-H\u00e9rault","year":"2005","journal-title":"Can. J. Vet. Res"},{"key":"2022071009271408200_CIT0011","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3201\/eid1405.070437","article-title":"Spread of Streptococcus suis sequence type 7, China","volume":"14","author":"Ye","year":"2008","journal-title":"Emerg. Infect. Dis"},{"key":"2022071009271408200_CIT0012","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1128\/iai.63.5.1975-1979.1995","article-title":"Discrimination of virulent and avirulent Streptococcus suis capsular type 2 isolates from different geographical origins","volume":"63","author":"Quessy","year":"1995","journal-title":"Infect. Immun"},{"key":"2022071009271408200_CIT0013","doi-asserted-by":"crossref","first-page":"e0137760","DOI":"10.1371\/journal.pone.0137760","article-title":"Complex population structure and virulence differences among serotype 2 streptococcus suis strains belonging to sequence type 28","volume":"10","author":"Athey","year":"2015","journal-title":"PLoS One"},{"key":"2022071009271408200_CIT0014","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2217\/fmb.11.149","article-title":"Virulence factors involved in the pathogenesis of the infection caused by the swine pathogen and zoonotic agent Streptococcus suis","volume":"7","author":"Fittipaldi","year":"2012","journal-title":"Future Microbiol"},{"key":"2022071009271408200_CIT0015","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1002\/1873-3468.12364","article-title":"Initial steps of the pathogenesis of the infection caused by Streptococcus suis: fighting against nonspecific defenses","volume":"590","author":"Segura","year":"2016","journal-title":"FEBS Lett"},{"key":"2022071009271408200_CIT0016","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.tim.2017.02.005","article-title":"Critical streptococcus suis virulence factors: are they all really critical?","volume":"25","author":"Segura","year":"2017","journal-title":"Trends Microbiol"},{"key":"2022071009271408200_CIT0017","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1017\/S146625230999003X","article-title":"Surface-associated and secreted factors of Streptococcus suis in epidemiology, pathogenesis and vaccine development","volume":"10","author":"Baums","year":"2009","journal-title":"Anim. Health Res. Rev"},{"key":"2022071009271408200_CIT0018","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1017\/S1466252307001247","article-title":"Streptococcus suis infections in humans: the Chinese experience and the situation in North America","volume":"8","author":"Gottschalk","year":"2007","journal-title":"Anim. Health Res. Rev"},{"key":"2022071009271408200_CIT0019","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tim.2009.12.003","article-title":"Uncovering newly emerging variants of Streptococcus suis, an important zoonotic agent","volume":"18","author":"Feng","year":"2010","journal-title":"Trends Microbiol"},{"key":"2022071009271408200_CIT0020","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"2022071009271408200_CIT0021","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat. Rev. Immunol"},{"key":"2022071009271408200_CIT0022","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fimmu.2014.00461","article-title":"Toll-like receptor signaling pathways","volume":"5","author":"Kawasaki","year":"2014","journal-title":"Front. Immunol"},{"key":"2022071009271408200_CIT0023","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1093\/intimm\/dxm003","article-title":"TLR2-dependent recognition of Streptococcus suis is modulated by the presence of capsular polysaccharide which modifies macrophage responsiveness","volume":"19","author":"Graveline","year":"2007","journal-title":"Int. Immunol"},{"key":"2022071009271408200_CIT0024","doi-asserted-by":"crossref","first-page":"e44746","DOI":"10.1371\/journal.pone.0044746","article-title":"Immune receptors involved in Streptococcus suis recognition by dendritic cells","volume":"7","author":"Lecours","year":"2012","journal-title":"PLoS One"},{"key":"2022071009271408200_CIT0025","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.vetmic.2009.12.010","article-title":"Differential activation of the Toll-like receptor 2\/6 complex by lipoproteins of Streptococcus suis serotypes 2 and 9","volume":"143","author":"Wichgers Schreur","year":"2010","journal-title":"Vet. Microbiol"},{"key":"2022071009271408200_CIT0026","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3389\/fmicb.2015.00644","article-title":"Toll-like receptor 4 confers inflammatory response to suilysin","volume":"6","author":"Bi","year":"2015","journal-title":"Front. Microbiol"},{"key":"2022071009271408200_CIT0027","doi-asserted-by":"crossref","first-page":"e65031","DOI":"10.1371\/journal.pone.0065031","article-title":"Toll-like receptor 2-independent host innate immune response against an epidemic strain of Streptococcus suis that causes a toxic shock-like syndrome in humans","volume":"8","author":"Lachance","year":"2013","journal-title":"PLoS One"},{"key":"2022071009271408200_CIT0028","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0378-1135(03)00030-0","article-title":"Mutagenesis of Streptococcus equi and Streptococcus suis by transposon Tn917","volume":"93","author":"Slater","year":"2003","journal-title":"Vet. Microbiol"},{"key":"2022071009271408200_CIT0029","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3201\/eid1708.060232","article-title":"Streptococcus suis sequence type 7 outbreak, Sichuan, China","volume":"12","author":"Ye","year":"2006","journal-title":"Emerg. Infect. Dis"},{"key":"2022071009271408200_CIT0030","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0378-1135(92)90094-A","article-title":"Production and characterization of two Streptococcus suis capsular type 2 mutants","volume":"30","author":"Gottschalk","year":"1992","journal-title":"Vet. Microbiol"},{"issue":"Pt 4","key":"2022071009271408200_CIT0031","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1099\/jmm.0.47755-0","article-title":"Allelic variation and prevalence of serum opacity factor among the Streptococcus suis population","volume":"57","author":"Takamatsu","year":"2008","journal-title":"J. Med. Microbiol"},{"key":"2022071009271408200_CIT0032","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.3201\/eid1712.110609","article-title":"Lineage and virulence of Streptococcus suis serotype 2 isolates from North America","volume":"17","author":"Fittipaldi","year":"2011","journal-title":"Emerg. Infect. Dis"},{"key":"2022071009271408200_CIT0033","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/eji.200636553","article-title":"Impairment of dendritic cell function by excretory-secretory products: a potential mechanism for nematode-induced immunosuppression","volume":"37","author":"Segura","year":"2007","journal-title":"Eur. J. Immunol"},{"key":"2022071009271408200_CIT0034","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/infdis\/jir415","article-title":"Critical role for Streptococcus suis cell wall modifications and suilysin in resistance to complement-dependent killing by dendritic cells","volume":"204","author":"Lecours","year":"2011","journal-title":"J. Infect. Dis"},{"key":"2022071009271408200_CIT0035","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1128\/IAI.00350-08","article-title":"Comparison of the susceptibilities of C57BL\/6 and A\/J mouse strains to Streptococcus suis serotype 2 infection","volume":"76","author":"Dom\u00ednguez-Punaro","year":"2008","journal-title":"Infect. Immun"},{"key":"2022071009271408200_CIT0036","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1007\/s10096-012-1581-2","article-title":"Severe cochlear inflammation and vestibular syndrome in an experimental model of Streptococcus suis infection in mice","volume":"31","author":"Dom\u00ednguez-Punaro","year":"2012","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis"},{"key":"2022071009271408200_CIT0037","doi-asserted-by":"crossref","first-page":"e0200453","DOI":"10.1371\/journal.pone.0200453","article-title":"Role of the Streptococcus suis serotype 2 capsular polysaccharide in the interactions with dendritic cells is strain-dependent but remains critical for virulence","volume":"13","author":"Auger","year":"2018","journal-title":"PLoS One"},{"key":"2022071009271408200_CIT0038","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.4049\/jimmunol.172.10.6324","article-title":"Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease","volume":"172","author":"Mancuso","year":"2004","journal-title":"J. Immunol"},{"key":"2022071009271408200_CIT0039","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/10408363.2013.764490","article-title":"Biomarkers of sepsis","volume":"50","author":"Faix","year":"2013","journal-title":"Crit. Rev. Clin. Lab. Sci"},{"key":"2022071009271408200_CIT0040","doi-asserted-by":"crossref","first-page":"635670","DOI":"10.1155\/2015\/635670","article-title":"Clinical applications of hemolytic markers in the differential diagnosis and management of hemolytic anemia","volume":"2015","author":"Barcellini","year":"2015","journal-title":"Dis. Markers"},{"key":"2022071009271408200_CIT0041","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.3201\/eid2006.131167","article-title":"Streptococcus suis infection and malignancy in man, Spain","volume":"20","author":"G\u00f3mez-Zorrilla","year":"2014","journal-title":"Emerg. Infect. Dis"},{"key":"2022071009271408200_CIT0042","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/s12879-015-1136-0","article-title":"First human case report of sepsis due to infection with Streptococcus suis serotype 31 in Thailand","volume":"15","author":"Hatrongjit","year":"2015","journal-title":"BMC Infect. Dis"},{"issue":"Pt 6","key":"2022071009271408200_CIT0043","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/brain\/awh171","article-title":"MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS","volume":"127","author":"Koedel","year":"2004","journal-title":"Brain"},{"key":"2022071009271408200_CIT0044","doi-asserted-by":"crossref","first-page":"438","DOI":"10.4049\/jimmunol.170.1.438","article-title":"Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis","volume":"170","author":"Koedel","year":"2003","journal-title":"J. Immunol"},{"key":"2022071009271408200_CIT0045","doi-asserted-by":"crossref","first-page":"e0119727","DOI":"10.1371\/journal.pone.0119727","article-title":"Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2","volume":"10","author":"Fieber","year":"2015","journal-title":"PLoS One"},{"key":"2022071009271408200_CIT0046","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1128\/IAI.00965-08","article-title":"Toll-like receptor 2 deficiency is associated with enhanced severity of group B streptococcal disease","volume":"77","author":"Puliti","year":"2009","journal-title":"Infect. Immun"},{"key":"2022071009271408200_CIT0047","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1128\/IAI.72.2.788-794.2004","article-title":"Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice","volume":"72","author":"Branger","year":"2004","journal-title":"Infect. Immun"},{"key":"2022071009271408200_CIT0048","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1001\/archotol.131.11.1001","article-title":"Evaluation of importance of Toll-like receptor 4 in acute Streptococcus pneumoniae sinusitis in mice","volume":"131","author":"Luxameechanporn","year":"2005","journal-title":"Arch. Otolaryngol. Head Neck Surg"},{"key":"2022071009271408200_CIT0049","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1128\/IAI.02282-14","article-title":"Role of Toll-like receptor 13 in innate immune recognition of group B streptococci","volume":"82","author":"Signorino","year":"2014","journal-title":"Infect. Immun"},{"key":"2022071009271408200_CIT0050","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1073\/pnas.75.3.1534","article-title":"Haemophilus influenzae bacteremia and meningitis resulting from survival of a single organism","volume":"75","author":"Moxon","year":"1978","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2022071009271408200_CIT0051","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1128\/IAI.01349-12","article-title":"Resistance of the brain to Escherichia coli K1 infection depends on MyD88 signaling and the contribution of neutrophils and monocytes","volume":"81","author":"Ribes","year":"2013","journal-title":"Infect. Immun"},{"key":"2022071009271408200_CIT0052","doi-asserted-by":"crossref","first-page":"e00007","DOI":"10.1042\/AN20090004","article-title":"MyD88 expression by CNS-resident cells is pivotal for eliciting protective immunity in brain abscesses","volume":"1","author":"Garg","year":"2009","journal-title":"ASN Neuro"},{"key":"2022071009271408200_CIT0053","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/glia.20770","article-title":"NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens","volume":"57","author":"Chauhan","year":"2009","journal-title":"Glia"},{"key":"2022071009271408200_CIT0054","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neulet.2018.01.057","article-title":"NOD2-RIP2 contributes to the inflammatory responses of mice in vivo to Streptococcus pneumoniae","volume":"671","author":"Zheng","year":"2018","journal-title":"Neurosci. Lett"},{"key":"2022071009271408200_CIT0055","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/NEN.0b013e3182909f2f","article-title":"How does the brain limit the severity of inflammation and tissue injury during bacterial meningitis?","volume":"72","author":"Neal","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"2022071009271408200_CIT0056","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/CMR.00008-11","article-title":"Pathogenesis and pathophysiology of pneumococcal meningitis","volume":"24","author":"Mook-Kanamori","year":"2011","journal-title":"Clin. Microbiol. Rev"},{"key":"2022071009271408200_CIT0057","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1128\/IAI.01681-05","article-title":"Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis","volume":"74","author":"Weighardt","year":"2006","journal-title":"Infect. Immun"},{"key":"2022071009271408200_CIT0058","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1086\/342845","article-title":"Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation","volume":"186","author":"Echchannaoui","year":"2002","journal-title":"J. Infect. Dis"},{"key":"2022071009271408200_CIT0059","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jneuroim.2016.09.003","article-title":"Lack of Toll-like receptor 2 results in higher mortality of bacterial meningitis by impaired host resistance","volume":"299","author":"B\u00f6hland","year":"2016","journal-title":"J. Neuroimmunol"},{"key":"2022071009271408200_CIT0060","doi-asserted-by":"crossref","first-page":"7428","DOI":"10.1128\/IAI.73.11.7428-7435.2005","article-title":"Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess","volume":"73","author":"Kielian","year":"2005","journal-title":"Infect. Immun"}],"container-title":["International Immunology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/intimm\/advance-article-pdf\/doi\/10.1093\/intimm\/dxz033\/28495894\/dxz033.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/intimm\/article-pdf\/31\/11\/697\/44799187\/dxz033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/intimm\/article-pdf\/31\/11\/697\/44799187\/dxz033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T09:27:49Z","timestamp":1657445269000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/intimm\/article\/31\/11\/697\/5427080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,4]]},"references-count":60,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,4,4]]},"published-print":{"date-parts":[[2019,10,16]]}},"URL":"https:\/\/doi.org\/10.1093\/intimm\/dxz033","relation":{},"ISSN":["1460-2377"],"issn-type":[{"value":"1460-2377","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,11]]},"published":{"date-parts":[[2019,4,4]]}}}