{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:34:10Z","timestamp":1764570850887,"version":"3.37.3"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H06387","18H05022"],"award-info":[{"award-number":["16H06387","18H05022"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ono Pharmaceutical Company Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mast cells (MCs) play a critical role in oral allergen-induced anaphylaxis. However, the contribution of basophils to the anaphylaxis remains unclear. The inhibitory immunoreceptor Allergin-1 is highly expressed on MCs and basophils and inhibits Fc\u03b5RI-mediated signaling in MCs. Here, we show that Allergin-1-deficient (Milr1\u2212\/\u2212) mice developed more severe hypothermia, a higher mortality rate and a greater incidence of diarrhea than did wild-type (WT) mice in an oral ovalbumin (OVA)-induced food allergy model. MC-deficient Mas\u2013TRECK mice, which had been reconstituted with either WT or Milr1\u2212\/\u2212 bone marrow-derived cultured MCs, did not develop hypothermia in this food allergy model. On the other hand, depletion of basophils by injection of anti-CD200R3 antibody rescued Milr1\u2212\/\u2212 mice from lethal hypothermia but not from diarrhea. In vitro analyses demonstrated that Allergin-1 inhibits IgE-dependent activation of both human and mouse basophils. Thus, Allergin-1 on basophils selectively suppresses oral allergen-induced anaphylaxis.<\/jats:p>","DOI":"10.1093\/intimm\/dxz075","type":"journal-article","created":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T12:11:23Z","timestamp":1573301483000},"page":"213-219","source":"Crossref","is-referenced-by-count":12,"title":["Selective suppression of oral allergen-induced anaphylaxis by Allergin-1 on basophils in mice"],"prefix":"10.1093","volume":"32","author":[{"given":"Yu-Hsien","family":"Lin","sequence":"first","affiliation":[{"name":"Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba , Tsukuba, Ibaraki, Japan"},{"name":"Department of Immunology, Faculty of Medicine, University of Tsukuba , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-4803","authenticated-orcid":false,"given":"Satoko","family":"Tahara-Hanaoka","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Tsukuba , Tsukuba, Ibaraki, Japan"},{"name":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), and R&D Center for Innovative Drug Discovery, University of Tsukuba , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Tsukuba , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Yushima, Bunkyo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Kubo","sequence":"additional","affiliation":[{"name":"Division of Molecular Pathology, Research Institute for Biomedical Science, Tokyo University of Science , Yamazaki, Noda-shi, Chiba, Japan"},{"name":"Laboratory for Cytokine Regulation, RIKEN Center for Integrative Medical Sciences (IMS) , Tsurumi-ku, Yokohama, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Shibayama","sequence":"additional","affiliation":[{"name":"Research Center of Immunology, Tsukuba Institute, ONO Pharmaceutical Company, Ltd , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Karasuyama","sequence":"additional","affiliation":[{"name":"Department of Immune Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU) , Yushima, Bunkyo-ku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Immunology, Faculty of Medicine, University of Tsukuba , Tsukuba, Ibaraki, Japan"},{"name":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), and R&D Center for Innovative Drug Discovery, University of Tsukuba , Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,12,3]]},"reference":[{"key":"2022090619283630600_CIT0001","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2017.07.004","article-title":"Immunology of food allergy","volume":"47","author":"Tordesillas","year":"2017","journal-title":"Immunity"},{"key":"2022090619283630600_CIT0002","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1016\/j.jaip.2019.01.023","article-title":"Impact of omalizumab on food allergy in patients treated for asthma: a real-life study","volume":"7","author":"Fiocchi","year":"2019","journal-title":"J. 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