{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:28:11Z","timestamp":1760909291656,"version":"3.41.2"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patient isolation is widely used as a strategy for prevention and control of infection but may have unintended consequences for patients. Early recognition and response to acute deterioration is an essential component of safe, quality patient care and has not been explored for patients in isolation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The primary aims of this study were to (i) describe the timing, frequency and nature of clinical deterioration during hospital admission for patients with isolation precautions for infection control and (ii) compare the characteristics of patients who did and did not deteriorate during their initial period of isolation precautions for infection control.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective cohort study was conducted across three sites of a large Australian health service. The study sample were adult patients (\u226518\u2009years) admitted into isolation precautions within 24\u2009h of admission from 1 July 2019 to 31 December 2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 634 patients who fulfilled the study inclusion criteria. One in eight patients experienced at least one episode of clinical deterioration during their time in isolation with most episodes of deterioration occurring within the first 2\u2009days of admission. Timely Medical Emergency Team calls occurred in almost half the episodes of deterioration; however, the same proportion (47.2%) of deterioration episodes resulted in no Medical Emergency Team activation (afferent limb failure). In the 24\u2009h preceding each episode of clinical deterioration (n\u2009=\u2009180), 81.6% (n\u2009=\u2009147) of episodes were preceded by vital signs fulfilling pre-Medical Emergency Team criteria. Patients who deteriorated during isolation for infection control were older (median age 74.0 vs 71.0\u2009years, P\u2009=\u20090.042); more likely to live in a residential care facility (21.0% vs 7.2%, P\u2009=\u20090.006); had a longer initial period of isolation (4.0 vs 2.9\u2009days, P\u2009=\u2009&amp;lt;\u2009000.1) and hospital length-of-stay (median 4.9 vs 3.2\u2009days, P\u2009=\u2009&amp;lt;\u20090.001) and were more likely to die in hospital (12.3% vs 4.3%, P\u2009&amp;lt;\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patients in isolation precautions experienced high Medical Emergency Team afferent limb failure and most fulfilled pre-Medical Emergency Team criteria in the 24\u2009h preceding episodes of deterioration. Timely recognition and response to clinical deterioration continue to be essential in providing safe, quality patient care regardless of the hospital-care environment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/intqhc\/mzac020","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T12:12:08Z","timestamp":1647951128000},"source":"Crossref","is-referenced-by-count":2,"title":["Recognizing and responding to clinical deterioration in adult patients in isolation precautions for infection control: a retrospective cohort study"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8780-054X","authenticated-orcid":false,"given":"Debra","family":"Berry","sequence":"first","affiliation":[{"name":"Centre for Quality and Patient Safety\u2014Eastern Health Partnership, 2\/5 Arnold Street, Box Hill, VIC 3128, Australia"},{"name":"School of Nursing and Midwifery & Institute for Health Transformation, Deakin University, 1 Gheringhap Street, Geelong, VIC 3220, Australia"},{"name":"School of Nursing and Midwifery, Centre for Quality and Patient Safety Research & Institute for Health Transformation, Deakin University, 1 Gheringhap Street, Geelong, VIC 3220, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-141X","authenticated-orcid":false,"given":"Maryann","family":"Street","sequence":"additional","affiliation":[{"name":"Centre for Quality and Patient Safety\u2014Eastern Health Partnership, 2\/5 Arnold Street, Box Hill, VIC 3128, Australia"},{"name":"School of Nursing and Midwifery & Institute for Health Transformation, Deakin University, 1 Gheringhap Street, Geelong, VIC 3220, Australia"},{"name":"School of Nursing and Midwifery, Centre for Quality and Patient Safety Research & Institute for Health Transformation, Deakin University, 1 Gheringhap Street, Geelong, VIC 3220, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kylie","family":"Hall","sequence":"additional","affiliation":[{"name":"Eastern Health, 8 Arnold Street, Box Hill, VIC 3128, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie K","family":"Sprogis","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery & Institute for Health Transformation, Deakin University, 1 Gheringhap Street, Geelong, VIC 3220, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3801-2456","authenticated-orcid":false,"given":"Julie","family":"Considine","sequence":"additional","affiliation":[{"name":"Centre for Quality and Patient Safety\u2014Eastern Health Partnership, 2\/5 Arnold Street, Box Hill, VIC 3128, Australia"},{"name":"School of Nursing and Midwifery & Institute for Health Transformation, Deakin University, 1 Gheringhap Street, Geelong, VIC 3220, Australia"},{"name":"School of Nursing and Midwifery, Centre for Quality and Patient Safety Research & Institute for Health Transformation, Deakin University, 1 Gheringhap Street, Geelong, VIC 3220, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"article-title":"Recognising and Responding to Acute Deterioration Standard","year":"2019","author":"Australian Commission on Safety and Quality in Healthcare","key":"2022042213021978200_R1"},{"key":"2022042213021978200_R2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.7326\/0003-4819-158-5-201303051-00009","article-title":"Rapid-response systems as a patient safety strategy: a systematic review","volume":"158","author":"Winters","year":"2013","journal-title":"Ann Intern Med"},{"key":"2022042213021978200_R3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1056\/NEJMra0910926","article-title":"Rapid response teams","volume":"365","author":"Jones","year":"2011","journal-title":"N Engl J Med"},{"key":"2022042213021978200_R4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/0310057X9502300210","article-title":"The medical emergency team","volume":"23","author":"Lee","year":"1995","journal-title":"Anaesth Intensive Care"},{"key":"2022042213021978200_R5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/bmjqs-2011-000692","article-title":"What stops hospital clinical staff from following protocols? 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