{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T15:42:05Z","timestamp":1780328525341,"version":"3.54.1"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":63,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["SC210103"],"award-info":[{"award-number":["SC210103"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-22-1-0800"],"award-info":[{"award-number":["W81XWH-22-1-0800"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Margolis Foundation"},{"name":"University of Utah Research Foundation"},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AI155694"],"award-info":[{"award-number":["1R01AI155694"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"3iii Graduate Research Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Great Salt Lake (GSL), located northwest of Salt Lake City, UT, is the largest terminal lake in the USA. While the average salinity of seawater is ~3.3%, the salinity in GSL ranges between 5% and 28%. In addition to being a hypersaline environment, GSL also contains toxic concentrations of heavy metals, such as arsenic, mercury, and lead. The extreme environment of GSL makes it an intriguing subject of study, both for its unique microbiome and its potential to harbor novel natural product\u2013producing bacteria, which could be used as resources for the discovery of biologically active compounds. Though work has been done to survey and catalog bacteria found in GSL, the Lake\u2019s microbiome is largely unexplored, and little to no work has been done to characterize the natural product potential of GSL microbes. Here, we investigate the bacterial diversity of two important regions within GSL, describe the first genomic characterization of Actinomycetota isolated from GSL sediment, including the identification of two new Actinomycetota species, and provide the first survey of the natural product potential of GSL bacteria.<\/jats:p>","DOI":"10.1093\/ismeco\/ycae029","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T17:56:42Z","timestamp":1709056602000},"source":"Crossref","is-referenced-by-count":4,"title":["Bacterial diversity and chemical ecology of natural product\u2013producing bacteria from Great Salt Lake sediment"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-3558","authenticated-orcid":false,"given":"Elijah R","family":"Bring Horvath","sequence":"first","affiliation":[{"name":"University of Utah Department of Pharmacology and Toxicology, , Salt Lake City, UT 84112, United States"},{"name":"University of Utah School of Biological Sciences, , Salt Lake City, UT 84112, United States"},{"name":"University of Utah Department of Medicinal Chemistry, , Salt Lake City, UT 84112, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0933-0148","authenticated-orcid":false,"given":"William J","family":"Brazelton","sequence":"additional","affiliation":[{"name":"University of Utah School of Biological Sciences, , Salt Lake City, UT 84112, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9861-6131","authenticated-orcid":false,"given":"Min Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"University of California at San Diego Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, , CA 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0884-1640","authenticated-orcid":false,"given":"Reiko","family":"Cullum","sequence":"additional","affiliation":[{"name":"University of California at San Diego Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, , CA 92093, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6016-7510","authenticated-orcid":false,"given":"Matthew A","family":"Mulvey","sequence":"additional","affiliation":[{"name":"University of Utah School of Biological Sciences, , Salt Lake City, UT 84112, United States"},{"name":"University of Utah Henry Eyring Center for Cell and Genome Science, , Salt Lake City, UT 84112, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8955-1735","authenticated-orcid":false,"given":"William","family":"Fenical","sequence":"additional","affiliation":[{"name":"University of California at San Diego Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, , CA 92093, United States"},{"name":"University of California at San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, , CA 92093, United States"},{"name":"University of California at San Diego Moores Comprehensive Cancer Center, , CA 92037, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6273-5377","authenticated-orcid":false,"given":"Jaclyn M","family":"Winter","sequence":"additional","affiliation":[{"name":"University of Utah Department of Pharmacology and Toxicology, , Salt Lake City, UT 84112, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"2024032411231232600_ref1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10123-018-0008-z","article-title":"Great Salt Lake microbiology: a historical perspective","volume":"21","author":"Baxter","year":"2018","journal-title":"Int Microbiol"},{"key":"2024032411231232600_ref2","doi-asserted-by":"crossref","first-page":"art33","DOI":"10.1890\/ES10-00091.1","article-title":"The Great Salt Lake ecosystem (Utah, USA): long term data and a structural equation approach","volume":"2","author":"Belovsky","year":"2011","journal-title":"Ecosphere"},{"key":"2024032411231232600_ref3","volume-title":"Record Low for Great Salt Lake","author":"Carlowicz","year":"2021"},{"key":"2024032411231232600_ref4","article-title":"Salt lake confronts a future without a 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