{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:01:09Z","timestamp":1791939669052,"version":"4.3.4"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tamkeen award","award":["AD179"],"award-info":[{"award-number":["AD179"]}]},{"name":"NOAA Ecohab Program","award":["NA19NOS4780183"],"award-info":[{"award-number":["NA19NOS4780183"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Harmful Algal Blooms (HABs) of the toxigenic dinoflagellate Karenia brevis (KB) are pivotal in structuring the ecosystem of the Gulf of Mexico (GoM), decimating coastal ecology, local economies, and human health. Bacterial communities associated with toxigenic phytoplankton species play an important role in influencing toxin production in the laboratory, supplying essential factors to phytoplankton and even killing blooming species. However, our knowledge of the prevalence of these mechanisms during HAB events is limited, especially for KB blooms. Here, we introduced native microbial communities from the GoM, collected during two phases of a Karenia bloom, into KB laboratory cultures. Using bacterial isolation, physiological experiments, and shotgun metagenomic sequencing, we identified both putative enhancers and mitigators of KB blooms. Metagenome-assembled genomes from the Roseobacter clade showed strong correlations with KB populations during HABs, akin to symbionts. A bacterial isolate from this group of metagenome-assembled genomes, Mameliella alba, alleviated vitamin limitations of KB by providing it with vitamins B1, B7 and B12. Conversely, bacterial isolates belonging to Bacteroidetes and Gammaproteobacteria, Croceibacter atlanticus, and Pseudoalteromonas spongiae, respectively, exhibited strong algicidal properties against KB. We identified a serine protease homolog in P. spongiae that putatively drives the algicidal activity in this isolate. While the algicidal mechanism in C. atlanticus is unknown, we demonstrated the efficiency of C. atlanticus to mitigate KB growth in blooms from the GoM. Our results highlight the importance of specific bacteria in influencing the dynamics of HABs and suggest strategies for future HAB management.<\/jats:p>","DOI":"10.1093\/ismeco\/ycae164","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T07:22:54Z","timestamp":1734420174000},"source":"Crossref","is-referenced-by-count":14,"title":["Friends and foes: symbiotic and algicidal bacterial influence on\n                    <i>Karenia brevis<\/i>\n                    blooms"],"prefix":"10.1093","volume":"5","author":[{"given":"Cong","family":"Fei","sequence":"first","affiliation":[{"name":"Marine Microbiomics Laboratory, Biology Program, New York University Abu Dhabi , Abu Dhabi 129188 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Booker","sequence":"additional","affiliation":[{"name":"Bigelow Laboratory for Ocean Sciences , East Boothbay, ME 04544 ,","place":["United States"]},{"name":"Horn Point Laboratory, University of Maryland Center for Environmental Science , Cambridge, MD 21613 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Klass","sequence":"additional","affiliation":[{"name":"Red Tide Institute, Mote Marine Laboratory and Aquarium , Sarasota, FL 34236 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayani K","family":"Vidyarathna","sequence":"additional","affiliation":[{"name":"Horn Point Laboratory, University of Maryland Center for Environmental Science , Cambridge, MD 21613 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Hyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Horn Point Laboratory, University of Maryland Center for Environmental Science , Cambridge, MD 21613 ,","place":["United States"]},{"name":"Biology Department, Woods Hole Oceanographic Institution , Woods Hole, MA 02543 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin R","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Marine Microbiomics Laboratory, Biology Program, New York University Abu Dhabi , Abu Dhabi 129188 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Arshad","sequence":"additional","affiliation":[{"name":"Center for Genomics and Systems Biology, New York University Abu Dhabi , Abu Dhabi, 129188 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia M","family":"Glibert","sequence":"additional","affiliation":[{"name":"Horn Point Laboratory, University of Maryland Center for Environmental Science , Cambridge, MD 21613 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A","family":"Heil","sequence":"additional","affiliation":[{"name":"Red Tide Institute, Mote Marine Laboratory and Aquarium , Sarasota, FL 34236 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Mart\u00ednez Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Bigelow Laboratory for Ocean Sciences , East Boothbay, ME 04544 ,","place":["United States"]},{"name":"Horn Point Laboratory, University of Maryland Center for Environmental Science , Cambridge, MD 21613 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shady A","family":"Amin","sequence":"additional","affiliation":[{"name":"Marine Microbiomics Laboratory, Biology Program, New York University Abu Dhabi , Abu Dhabi 129188 ,","place":["United Arab Emirates"]},{"name":"Center for Genomics and Systems Biology, New York University Abu Dhabi , Abu Dhabi, 129188 ,","place":["United Arab Emirates"]},{"name":"Mubadala Arabian Center for Climate and Environmental Sciences Center, New York University Abu Dhabi , Abu Dhabi 129188 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"2025011717313840100_ref1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.hal.2016.05.003","article-title":"Harmful algal blooms and public health","volume":"57","author":"Grattan","year":"2016","journal-title":"Harmful Algae"},{"key":"2025011717313840100_ref2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1080\/20026491051695","article-title":"The effects of harmful algal blooms on aquatic organisms","volume":"10","author":"Landsberg","year":"2002","journal-title":"Rev Fish Sci"},{"key":"2025011717313840100_ref3","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1007\/BF02804901","article-title":"Harmful algal blooms and eutrophication: nutrient sources, 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Pyani v0.2.8: average nucleotide identity (ANI) and related measures for whole genome comparisons. 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