{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:36:23Z","timestamp":1776782183263,"version":"3.51.2"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":79,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute for Theoretical and Computational Sciences"},{"name":"National Research Foundation of South Africa","award":["89967"],"award-info":[{"award-number":["89967"]}]},{"name":"European Union's Horizon Europe Research and Innovation Programme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Macro-ecosystems, including the human gut, host a vast and diverse set of microbes that indirectly interact with each other through consuming and producing metabolites. Disruptions in this microbial network can affect macro-ecosystem functioning and, in the human gut, contribute to the onset and progression of various disorders, including diabetes, rheumatoid arthritis, and Parkinson\u2019s disease. A theoretical foundation for understanding the intricate and dynamic interactions between microbes and metabolites is essential for developing microbiota-targeted interventions to improve macro-ecosystem functioning and health. To this end, a precise mathematical framework is crucial to capture and quantify the complex dynamics of the microbial system. Here, we develop a dynamic network model of coupled ordinary differential equations and present a computational workflow that integrates a generative model with Bayesian inference for model identification. Our approach infers interaction rates, quantifying metabolite consumption and production from simulated time-series data within a Bayesian framework, incorporating prior knowledge and uncertainty quantification. We show that our approach is accurate and reliable in communities of various sizes, sparsity, and with different levels of observational noise. This workflow enables in silico predictions of system behaviour under perturbations and offers a robust method to integrate high-dimensional biological data with dynamic network models. By refining our understanding of microbial dynamics, this framework is capable of assessing microbiota-targeted interventions and their potential to improve the health of the macro-ecosystem.<\/jats:p>","DOI":"10.1093\/ismeco\/ycag066","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:56:12Z","timestamp":1773838572000},"source":"Crossref","is-referenced-by-count":0,"title":["Bayesian inference captures metabolite\u2013bacteria interactions in a microbial community"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2327-5790","authenticated-orcid":false,"given":"Jack","family":"Jansma","sequence":"first","affiliation":[{"name":"Biodiversity Informatics Unit, Department of Mathematical Sciences, Stellenbosch University , Stellenbosch 7600, Western cape ,","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Landi","sequence":"additional","affiliation":[{"name":"Biodiversity Informatics Unit, Department of Mathematical Sciences, Stellenbosch University , Stellenbosch 7600, Western cape ,","place":["South Africa"]},{"name":"National Institute for Theoretical and Computational Sciences , Stellenbosch 7600, Western cape ,","place":["South Africa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cang","family":"Hui","sequence":"additional","affiliation":[{"name":"Biodiversity Informatics Unit, Department of Mathematical Sciences, Stellenbosch University , Stellenbosch 7600, Western cape ,","place":["South Africa"]},{"name":"National Institute for Theoretical and Computational Sciences , Stellenbosch 7600, Western cape ,","place":["South Africa"]},{"name":"African Institute for Mathematical Sciences , Cape Town 7100, Western cape ,","place":["South 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