{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T08:02:10Z","timestamp":1784534530486,"version":"3.55.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":172,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Members of the class Ktedonobacteria (phylum Chloroflexota) are widespread across various terrestrial environments, including oligotrophic caves, although the genomic basis underlying this distribution remains unclear. Here, we present a systematic genomic analysis of Ktedonobacteria across ecosystems, with a focus on oligotrophic caves. Cave Ktedonobacteria belong to novel genera within the Ktedonobacteraceae and harbour genes associated with a mixotrophic metabolism combining the use of organic and inorganic substrates as energy and carbon sources. Comparative analyses of all available Ktedonobacteria genomes from diverse environments showed that most metabolic traits, including those associated with atmospheric gas oxidation, are primarily conserved among members of the same family. In contrast, genes involved in CO\u2082 fixation are enriched in Ktedonobacteria inhabiting caves. Phylogenetic analysis indicated that the RuBisCO of Ktedonobacteria likely represents a novel Form I subtype (named group IG) encompassing thermophilic and acidophilic bacteria from six different phyla that often inhabit similar extreme environments. The presence of this subtype across distinct lineages in comparable habitats suggests that it may confer a selective advantage in nutrient-poor settings (like caves) and that its distribution may be influenced by horizontal gene transfer. This inferred autotrophic capacity is associated with a transaldolase variant of the Calvin\u2013Benson\u2013Bassham cycle that was previously described only in a single Firmicutes species. Overall, this study provides genetic evidence for the potential coupling of atmospheric gas oxidation with dark CO\u2082 fixation in Ktedonobacteria, highlighting their possible role in sustaining primary production in oligotrophic ecosystems, including caves.<\/jats:p>","DOI":"10.1093\/ismeco\/ycag175","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T11:39:41Z","timestamp":1781955581000},"source":"Crossref","is-referenced-by-count":0,"title":["Genomic evidence for aerotrophy as a defining trait of Ktedonobacteria inhabiting silica-rich oligotrophic caves"],"prefix":"10.1093","volume":"6","author":[{"given":"Andrea","family":"Firrincieli","sequence":"first","affiliation":[{"name":"Department for Innovation in Biological, Agro-Food and Forest Systems (DIBAF), University of Tuscia , 01100 Viterbo ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Broglia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology (FaBit), University of Bologna , 40129 Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology (FaBit), University of Bologna , 40129 Bologna ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Greggio","sequence":"additional","affiliation":[{"name":"Department of Biological, Geological and Environmental Sciences (BiGeA), University of Bologna , 48100 Ravenna Campus ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Ghezzi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology (FaBit), University of 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