{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:26:17Z","timestamp":1788456377687,"version":"build-2803163510"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":211,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Graduate School of Medical Sciences of the University of Groningen"},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202206790018"],"award-info":[{"award-number":["202206790018"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Faecalibacterium is one of the most abundant anaerobes in the human colon. At the genus level, this bacterium shows a strong positive association with human health. Expanding collections of isolates and metagenome-assembled genomes have revealed its species diversity, yet species-level functions remain so far underexplored. Here, we describe a novel species, Faecalibacterium harmsenii. In addition, we reclassify another isolate as a member of the recently reported Faecalibacterium langellae species. Despite close genomic relatedness, these isolates exhibit distinct physiological and biochemical traits, including differences in carbohydrate utilization, stress tolerance, enzymatic activity, Gram-staining and fatty acid composition. Our present comparative genomics analyses further uncover extensive functional diversity and plasticity across type strains, with F. harmsenii being distinguished by an expanded carbohydrate gene repertoire and reduced defense systems, mobile genetic elements and antibiotic resistance genes. Extending to the species, we identify species-specific ecological niches across hosts and differential sensitivities to human diseases, highlighting certain species as reliable biomarkers of gut health. Together, these findings refine our understanding of Faecalibacterium diversity and provide a framework for its use in microbiome-based diagnostics and therapeutic development.<\/jats:p>","DOI":"10.1093\/ismeco\/ycag221","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:19:05Z","timestamp":1785323945000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>Faecalibacterium harmsenii<\/i>\n                    sp. nov.\n                    <i>,<\/i>\n                    an abundant but previously overlooked\n                    <i>Faecalibacterium<\/i>\n                    in the human gut"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9441-6864","authenticated-orcid":false,"given":"Qiqi","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Infection prevention, University of Groningen, University Medical Center Groningen , Hanzeplein 1, Groningen, GZ 9713 ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Tsompanidou","sequence":"additional","affiliation":[{"name":"Winclove Probiotics , tt. Vasumweg 221, Amsterdam, SJ 1033 ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbing","family":"Hu","sequence":"additional","affiliation":[{"name":"Jiangxi Key Laboratory of Natural Products and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University , Nanchang 330045 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Tanweer","family":"Khan","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Sahlgrenska University Hospital , Bruna Str\u00e5ket 16, Gothenburg, SE-413 45 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5688-8438","authenticated-orcid":false,"given":"Jan Maarten","family":"van Dijl","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infection prevention, University of Groningen, University Medical Center Groningen , 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