{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:58Z","timestamp":1792786018518,"version":"4.5.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":170,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fond Unique Interminist\u00e9riels"},{"name":"Fonds Europ\u00e9en de D\u00e9veloppement \u00c9conomique et R\u00e9gional"},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-14-LAB7-0001"],"award-info":[{"award-number":["ANR-14-LAB7-0001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-17-CE20\u20130030"],"award-info":[{"award-number":["ANR-17-CE20\u20130030"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"R\u00e9gion Occitanie"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The rhizosphere, which serves as the primary interface between plant roots and the soil, constitutes an ecological niche for a huge diversity of microbial communities. Currently, there is little knowledge on the nature and the function of the different metabolites released by rhizospheric microbes to facilitate colonization of this highly competitive environment. Here, we demonstrate how the production of galbonolides, a group of polyene macrolides that inhibit plant and fungal inositol phosphorylceramide synthase (IPCS), empowers the rhizospheric Streptomyces strain AgN23, to thrive in the rhizosphere by triggering the plant\u2019s defence mechanisms. Metabolomic analysis of AgN23-inoculated Arabidopsis roots revealed a strong induction in the production of an indole alkaloid, camalexin, which is a major phytoalexin in Arabidopsis. By using a plant mutant compromised in camalexin synthesis, we show that camalexin production is necessary for the successful colonization of the rhizosphere by AgN23. Conversely, hindering galbonolides biosynthesis in AgN23 knock-out mutant resulted in loss of inhibition of IPCS, a deficiency in plant defence activation, notably the production of camalexin, and a strongly reduced development of the mutant bacteria in the rhizosphere. Together, our results identified galbonolides as important metabolites mediating rhizosphere colonization by Streptomyces.<\/jats:p>","DOI":"10.1093\/ismejo\/wrae112","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T08:58:30Z","timestamp":1718787510000},"source":"Crossref","is-referenced-by-count":23,"title":["Root-associated\n                    <i>Streptomyces<\/i>\n                    produce galbonolides to modulate plant immunity and promote rhizosphere colonization"],"prefix":"10.1093","volume":"18","author":[{"given":"Cl\u00e9ment","family":"Nicolle","sequence":"first","affiliation":[{"name":"Laboratoire de Recherche en Sciences V\u00e9g\u00e9tales , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]},{"name":"Universit\u00e9 Toulouse III, Toulouse INP , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Gayrard","sequence":"additional","affiliation":[{"name":"Laboratoire de Recherche en Sciences V\u00e9g\u00e9tales , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]},{"name":"Universit\u00e9 Toulouse III, Toulouse INP , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]},{"name":"DE SANGOSSE , 47480 Pont-Du-Casse,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"No\u00ebl","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC) , 91198 Gif-sur-Yvette,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Hortala","sequence":"additional","affiliation":[{"name":"Laboratoire de Recherche en Sciences V\u00e9g\u00e9tales , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]},{"name":"Universit\u00e9 Toulouse III, Toulouse INP , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Amiel","sequence":"additional","affiliation":[{"name":"Laboratoire de Recherche en Sciences V\u00e9g\u00e9tales , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]},{"name":"Universit\u00e9 Toulouse III, Toulouse INP , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]},{"name":"DE SANGOSSE , 47480 Pont-Du-Casse,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Grat","sequence":"additional","affiliation":[{"name":"Laboratoire de Recherche en Sciences V\u00e9g\u00e9tales , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]},{"name":"Universit\u00e9 Toulouse III, Toulouse INP , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Le Ru","sequence":"additional","affiliation":[{"name":"Plateforme d\u2019Imagerie FRAIB-TRI, Universit\u00e9 de Toulouse, CNRS , Auzeville-Tolosane 31320,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Marti","sequence":"additional","affiliation":[{"name":"Laboratoire de Recherche en Sciences V\u00e9g\u00e9tales , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]},{"name":"Universit\u00e9 Toulouse III, Toulouse INP , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]},{"name":"Metatoul-AgromiX Platform, LRSV, Universit\u00e9 de Toulouse, CNRS, UPS, Toulouse INP , Toulouse,","place":["France"]},{"name":"MetaboHUB-MetaToul, National Infrastructure of Metabolomics and Fluxomics , Toulouse,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Luc","family":"Pernodet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC) , 91198 Gif-sur-Yvette,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Lautru","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC) , 91198 Gif-sur-Yvette,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Dumas","sequence":"additional","affiliation":[{"name":"Laboratoire de Recherche en Sciences V\u00e9g\u00e9tales , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]},{"name":"Universit\u00e9 Toulouse III, Toulouse INP , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Rey","sequence":"additional","affiliation":[{"name":"Laboratoire de Recherche en Sciences V\u00e9g\u00e9tales , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]},{"name":"Universit\u00e9 Toulouse III, Toulouse INP , Universit\u00e9 de Toulouse, CNRS, , 24 Chemin de Borde Rouge, Auzeville, Auzeville-Tolosane 31320,","place":["France"]},{"name":"DE SANGOSSE , 47480 Pont-Du-Casse,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"2024100914305333400_ref1","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1038\/ismej.2015.7","article-title":"Cross-kingdom similarities in microbiome functions","volume":"9","author":"Mendes","year":"2015","journal-title":"ISME J"},{"key":"2024100914305333400_ref2","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s41564-023-01382-2","article-title":"Streptomyces polyketides mediate bacteria\u2013fungi interactions across soil 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