{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:01:08Z","timestamp":1789790468296,"version":"4.0.1"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":288,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH NIAID","award":["R01AI143288"],"award-info":[{"award-number":["R01AI143288"]}]},{"DOI":"10.13039\/100000015","name":"DOE","doi-asserted-by":"publisher","award":["DE-SC0021350"],"award-info":[{"award-number":["DE-SC0021350"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH Predoctoral Training","award":["T32GM132057"],"award-info":[{"award-number":["T32GM132057"]}]},{"name":"NIH Predoctoral Training","award":["T32Al162691"],"award-info":[{"award-number":["T32Al162691"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Salmonella enterica serovar Typhimurium is a pervasive enteric pathogen and ongoing global threat to public health. Ecological studies in the Salmonella impacted gut remain underrepresented in the literature, discounting microbiome mediated interactions that may inform Salmonella physiology during colonization and infection. To understand the microbial ecology of Salmonella remodeling of the gut microbiome, we performed multi-omics on fecal microbial communities from untreated and Salmonella-infected mice. Reconstructed genomes recruited metatranscriptomic and metabolomic data providing a strain-resolved view of the expressed metabolisms of the microbiome during Salmonella infection. These data informed possible Salmonella interactions with members of the gut microbiome that were previously uncharacterized. Salmonella-induced inflammation significantly reduced the diversity of genomes that recruited transcripts in the gut microbiome, yet increased transcript mapping was observed for seven members, among which Luxibacter and Ligilactobacillus transcript read recruitment was most prevalent. Metatranscriptomic insights from Salmonella and other persistent taxa in the inflamed microbiome further expounded the necessity for oxidative tolerance mechanisms to endure the host inflammatory responses to infection. In the inflamed gut lactate was a key metabolite, with microbiota production and consumption reported amongst members with detected transcript recruitment. We also showed that organic sulfur sources could be converted by gut microbiota to yield inorganic sulfur pools that become oxidized in the inflamed gut, resulting in thiosulfate and tetrathionate that support Salmonella respiration. This research advances physiological microbiome insights beyond prior amplicon-based approaches, with the transcriptionally active organismal and metabolic pathways outlined here offering intriguing intervention targets in the Salmonella-infected intestine.<\/jats:p>","DOI":"10.1093\/ismejo\/wrae187","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T11:38:38Z","timestamp":1728992318000},"source":"Crossref","is-referenced-by-count":14,"title":["Gut microbiota carbon and sulfur metabolisms support <i>Salmonella<\/i> infections"],"prefix":"10.1093","volume":"18","author":[{"given":"Ikaia","family":"Leleiwi","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, Colorado State University , Plant Sciences Bldg. 307 University Ave, Fort Collins, CO 80523,","place":["United States"]},{"name":"Department of Soil and Crop Sciences, Colorado State University , Plant Sciences Bldg. 307 University Ave, Fort Collins, CO 80523,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Kokkinias","sequence":"additional","affiliation":[{"name":"Department of Soil and Crop Sciences, Colorado State University , Plant Sciences Bldg. 307 University Ave, Fort Collins, CO 80523,","place":["United States"]},{"name":"Department of Microbiology , Immunology, and Pathology, Microbiology Building, 1682 Campus Delivery Colorado State University, Fort Collins, CO 80523,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongseok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry , The Ohio State University, 200 CBEC Building 151 W. Woodruff Ave. Columbus, OH 43210,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Baniasad","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry , The Ohio State University, 200 CBEC Building 151 W. 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Woodruff Ave. Columbus, OH 43210,","place":["United States"]},{"name":"Resource for Native Mass Spectrometry Guided Structural Biology , The Ohio State University, 280 Biomedical Research Tower 460 W. 12th Ave. Columbus, OH 43210,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M M","family":"Ahmer","sequence":"additional","affiliation":[{"name":"Department of Microbial Infection and immunity , The Ohio State University, 776 Biomedical Research Tower, 460 W. 12th Avenue, Columbus, OH 43210-2210,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikayla A","family":"Borton","sequence":"additional","affiliation":[{"name":"Department of Soil and Crop Sciences, Colorado State University , Plant Sciences Bldg. 307 University Ave, Fort Collins, CO 80523,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly 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