{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:27:45Z","timestamp":1791520065282,"version":"4.3.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":110,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Center Project of the Natural Science Foundation of China","award":["52388101"],"award-info":[{"award-number":["52388101"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC1806904"],"award-info":[{"award-number":["2020YFC1806904"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3704600"],"award-info":[{"award-number":["2022YFC3704600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42277386"],"award-info":[{"award-number":["42277386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Antibiotic-manufacturing wastewater treatment plants primarily target chemical pollutants, but their processes may select for antibiotic-resistant pathogens and antibiotic resistance genes. Leveraging the combined strengths of deep metagenomic sequencing, 16S rRNA gene sequencing, quantitative polymerase chain reaction, and bacterial culturing, we investigated bacterial communities and antibiotic resistomes across eleven treatment units in a full-scale antibiotic-manufacturing wastewater treatment plant processing wastewater from a \u03b2-lactam manufacturing facility. Both bacterial communities and antibiotic resistance gene compositions varied across the treatment units, but were associated. Certain antibiotic resistance gene persisted through treatment, either carried by identical bacterial species, or linked to mobile genetic elements in different species. Despite the satisfactory performance in chemical removal, this plant continuously enriched zoonotic antibiotic-resistant Aeromonas veronii (an emerging pathogen responsible for substantial economic losses in aquaculture and human health) from influent to effluent, probably due to prolonged \u03b2-lactam selection pressure and aquatic nature of A. veronii. This enrichment resulted in a significantly higher abundance of A. veronii than other aquatic samples worldwide. Furthermore, the closest evolutionary relative to the retrieved A. veronii was an isolate obtained from the stool of a local diarrhea patient. These findings highlighted a substantial public health risk posed by antibiotic-manufacturing wastewater treatment, underlining its potential role in enriching and disseminating zoonotic antibiotic-resistant pathogens. Beyond chemical monitoring, enhanced surveillance of antibiotic-resistant pathogens and antibiotic resistance genes is needed in effluent discharge standard for antibiotic-manufacturing wastewater treatment plants.<\/jats:p>","DOI":"10.1093\/ismejo\/wraf077","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T12:29:23Z","timestamp":1745238563000},"source":"Crossref","is-referenced-by-count":17,"title":["Treatment of antibiotic-manufacturing wastewater enriches for <i>Aeromonas veronii<\/i>, a zoonotic antibiotic-resistant emerging pathogen"],"prefix":"10.1093","volume":"19","author":[{"given":"Xingshuo","family":"Wang","sequence":"first","affiliation":[{"name":"College of Environmental Science and Engineering, Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria, Nankai University , Tianjin 300071 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M","family":"Tiedje","sequence":"additional","affiliation":[{"name":"Department of Plant, Soil and Microbial Sciences, Michigan State University , East Lansing, MI 48824 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizhong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute for Environmental Genomics and Department of Microbiology and Plant Biology, University of Oklahoma , Norman, OK 73019 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Topp","sequence":"additional","affiliation":[{"name":"Agroecology Research Unit, Bourgogne Franche-Comt\u00e9 Research Centre, National Research Institute for Agriculture, Food and the Environment , Dijon 35000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Water Pollution Control and Green 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