{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:02:29Z","timestamp":1791442949789,"version":"4.3.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":334,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Secretory Immunoglobulin A (SIgA) is the dominant mucosal antibody and a key regulator of the gut microbiota. In early life, infants rely on breastmilk as their primary source of SIgA, but the role of milk-derived SIgA in early life microbiota colonization dynamics remains incompletely understood. Here, we show that species-specific SIgA in milk is antigen-inducible and discriminates between closely related but immunologically diverging microbes in the neonatal gut. More specifically, milk species-specific SIgA promotes colonization by an anti-inflammatory Escherichia coli strain while restricting the expansion of pro-inflammatory Proteus mirabilis. These findings uncover a dual role of maternal milk SIgA in actively sculpting the early life gut microbiota with species-level precision.<\/jats:p>","DOI":"10.1093\/ismejo\/wraf266","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:08:52Z","timestamp":1764248932000},"source":"Crossref","is-referenced-by-count":2,"title":["Milk IgA promotes symbionts and limits pathobionts in the early life gut"],"prefix":"10.1093","volume":"19","author":[{"given":"Katherine","family":"Donald","sequence":"first","affiliation":[{"name":"Department of Microbiology & Immunology, University of British Columbia , 2350 Health Sciences Mall #1365, Vancouver, BC V6T 1Z3 ,","place":["Canada"]},{"name":"Michael Smith Laboratories, University of British Columbia , 2185 East Mall, Vancouver, BC V6T1Z4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Serapio-Palacios","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories, University of British Columbia , 2185 East Mall, Vancouver, BC V6T1Z4 ,","place":["Canada"]},{"name":"Department of Microbiology and Molecular Genetics, University of California , Briggs Hall, 550 Storer Mall, Davis, CA 95616,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahereh","family":"Bozorgmehr","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories, University of British Columbia , 2185 East Mall, Vancouver, BC V6T1Z4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahebali","family":"Tabusi","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, University of British Columbia , 2350 Health Sciences Mall #1365, Vancouver, BC V6T 1Z3 ,","place":["Canada"]},{"name":"Michael Smith Laboratories, University of British Columbia , 2185 East Mall, Vancouver, BC V6T1Z4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5303-6128","authenticated-orcid":false,"given":"B Brett","family":"Finlay","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, University of British Columbia , 2350 Health Sciences Mall #1365, Vancouver, BC V6T 1Z3 ,","place":["Canada"]},{"name":"Michael Smith Laboratories, University of British Columbia , 2185 East Mall, Vancouver, BC V6T1Z4 ,","place":["Canada"]},{"name":"Department of Biochemistry and Molecular Biology, University of British Columbia , Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, BC V6T 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