{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:09:00Z","timestamp":1789517340221,"version":"build-2803163510"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":71,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDA0510200"],"award-info":[{"award-number":["XDA0510200"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Intestinal microbiota resists pathogenic bacterial infections through colonization resistance, largely attributed to direct microbial competition. However, whether commensals can provide colonization resistance by remodeling the host epithelial niche remains underexplored. Here, by combining in vivo mouse models and a gut-on-chip model, this study demonstrates that the resistance of commensal Escherichia coli Nissle 1917 (EcN) against Salmonella Typhimurium (STm) infection is strictly dependent on EcN precolonization. Mechanistically, the EcN outer membrane protein MipA was identified as a key factor that induces the upregulation of integrin-linked kinase (ILK), thereby reinforcing tight junction integrity and restricting Salmonella infection. Engineering a nonprotective strain to express MipA was sufficient to confer resistance against Salmonella infection. This work reveals an epithelial defense mechanism triggered by a specific probiotic protein, with implications for developing preventive strategies against enteric infections.<\/jats:p>","DOI":"10.1093\/ismejo\/wrag054","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:41:54Z","timestamp":1773330114000},"source":"Crossref","is-referenced-by-count":3,"title":["Cellular membrane protein MipA from\n                    <i>E.coli<\/i>\n                    Nissle 1917 protects against\n                    <i>Salmonella<\/i>\n                    infection"],"prefix":"10.1093","volume":"20","author":[{"given":"Yunqing","family":"Xiang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen, Guangdong 518055 ,","place":["China"]},{"name":"Department of Mechanical, Materials and Manufacturing Engineering, University of Nottingham Ningbo China , Ningbo 315100 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huipai","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen, Guangdong 518055 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Epigenetics for Organ Development of Premature Infants, Tianjin Fifth Central Hospital , Tianjin 300450 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen, Guangdong 518055 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen, Guangdong 518055 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Epigenetics for Organ Development of Premature Infants, Tianjin Fifth Central Hospital , Tianjin 300450 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Superlattices and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences , Beijing 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