{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:46:26Z","timestamp":1791989186394,"version":"4.4.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The human nasal microbiome is a low-diversity ecosystem whose assembly principles and mechanisms of colonization resistance remain poorly understood. Staphylococcus aureus is a member of the nasal microbiome of some individuals with variable abundance. We hypothesized that nutritional competition, strain-level diversity, and nutrient availability shape community stability and the ability of commensal species to inhibit S. aureus. To test this, we constructed 50 defined synthetic communities inoculated with 5 to 10 representative human nasal bacterial species differing in strain and species composition and tracked their compositional changes across serial passages, S. aureus growth, metabolic profiles, and nutritional interactions. The resulting consortia, which assembled into communities of up to 6 co-existing species converged in one of three community types. Synthetic communities dominated by specific Corynebacterium propinquum strains showed exclusion of most other community members, including S. aureus. Conversely, communities lacking C. propinquum dominance showed that exclusion of S. aureus was driven primarily by a combination of Staphylococcus epidermidis and Staphylococcus lugdunensis. Growth and coculture assays showed that C. propinquum outcompetes S. aureus in conditions that resemble the nasal environment, whereas S. aureus dominates in nutrient-rich conditions. Metabolomics analyses indicated that nutritional competition, including siderophore utilization and amino acid limitation, likely underlies this colonization resistance. These results establish a reproducible and tractable synthetic community model for the human nasal microbiome and suggest that nutrient-dependent competition and microbial metabolite production are key drivers of community structure and pathogen exclusion.<\/jats:p>","DOI":"10.1093\/ismejo\/wrag268","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:50:28Z","timestamp":1791978628000},"source":"Crossref","is-referenced-by-count":0,"title":["Community composition drives metabolic competition and\n                    <i>Staphylococcus aureus<\/i>\n                    colonization resistance in synthetic nasal communities"],"prefix":"10.1093","author":[{"given":"Marcelo","family":"Navarro-Diaz","sequence":"first","affiliation":[{"name":"Interfaculty Institute of Microbiology and Infection Medicine, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Cluster of Excellence \u201cControlling Microbes to Fight Infections\u201d, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"M3 Research Center, University of T\u00fcbingen , Otfried-M\u00fcller-Str. 37, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerrin","family":"Bertram","sequence":"additional","affiliation":[{"name":"Interfaculty Institute of Microbiology and Infection Medicine, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Cluster of Excellence \u201cControlling Microbes to Fight Infections\u201d, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"M3 Research Center, University of T\u00fcbingen , Otfried-M\u00fcller-Str. 37, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"G\u00f6bel","sequence":"additional","affiliation":[{"name":"Interfaculty Institute of Microbiology and Infection Medicine, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Cluster of Excellence \u201cControlling Microbes to Fight Infections\u201d, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"M3 Research Center, University of T\u00fcbingen , Otfried-M\u00fcller-Str. 37, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Camus","sequence":"additional","affiliation":[{"name":"Interfaculty Institute of Microbiology and Infection Medicine, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Cluster of Excellence \u201cControlling Microbes to Fight Infections\u201d, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoung","family":"Ham","sequence":"additional","affiliation":[{"name":"Cluster of Excellence \u201cControlling Microbes to Fight Infections\u201d, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Environmental Biotechnology Group, Department of Geosciences, University of T\u00fcbingen , Schnarrenbergstra\u00dfe 94-96, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Largus T","family":"Angenent","sequence":"additional","affiliation":[{"name":"Cluster of Excellence \u201cControlling Microbes to Fight Infections\u201d, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Environmental Biotechnology Group, Department of Geosciences, University of T\u00fcbingen , Schnarrenbergstra\u00dfe 94-96, 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Max Planck Institute for Biology T\u00fcbingen , Max-Planck-Ring 5, 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Department of Biological and Chemical Engineering, Aarhus University , Gustav Wieds Vej 10D, 8000 Aarhus C ,","place":["Denmark"]},{"name":"The Novo Nordisk Foundation CO2 Research Center (CORC), Aarhus University , Gustav Wieds Vej 10C, 8000 Aarhus C ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio Velazquez","family":"Gomez","sequence":"additional","affiliation":[{"name":"Cluster of Excellence \u201cControlling Microbes to Fight Infections\u201d, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Environmental Biotechnology Group, Department of Geosciences, University of T\u00fcbingen , Schnarrenbergstra\u00dfe 94-96, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Heilbronner","sequence":"additional","affiliation":[{"name":"Interfaculty Institute of Microbiology and Infection Medicine, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Cluster of Excellence \u201cControlling Microbes to Fight Infections\u201d, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Stincone","sequence":"additional","affiliation":[{"name":"Interfaculty Institute of Microbiology and Infection Medicine, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Cluster of Excellence \u201cControlling Microbes to Fight Infections\u201d, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4591-8312","authenticated-orcid":false,"given":"Johanna","family":"Rapp","sequence":"additional","affiliation":[{"name":"Interfaculty Institute of Microbiology and Infection Medicine, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Cluster of Excellence \u201cControlling Microbes to Fight Infections\u201d, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"M3 Research Center, University of T\u00fcbingen , Otfried-M\u00fcller-Str. 37, 72076 T\u00fcbingen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Petras","sequence":"additional","affiliation":[{"name":"Interfaculty Institute of Microbiology and Infection Medicine, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Cluster of Excellence \u201cControlling Microbes to Fight Infections\u201d, University of T\u00fcbingen , 72076 T\u00fcbingen ,","place":["Germany"]},{"name":"Department of Biochemistry, University of California , Riverside, 169 Aberdeen Dr., Riverside, CA 92507 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6677-555X","authenticated-orcid":false,"given":"Hannes","family":"Link","sequence":"additional","affiliation":[{"name":"Interfaculty Institute of Microbiology and 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