{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:16:39Z","timestamp":1787498199221,"version":"build-2736575974"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"suppl_2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Moxifloxacin, a broad-spectrum fluoroquinolone with the methoxy group at position 8 of the quinolone structure that is believed to confer reduced phototoxicity, was investigated in 32 healthy human male volunteers by a randomized double-blind placebo and positive control (lomefloxacin) phototest technique. A comparison of pre- and on-drug photosensitivity levels tested with an irradiation monochromator using relevant sunlight wavelengths, failed to demonstrate phototoxicity after administration of either placebo or moxifloxacin (200 mg or 400 mg\/day) for 7 days. As expected, lomefloxacin (400 mg\/day) phototoxicity was revealed at the UVA wavebands 335 \u00b1 30 nm and 365 \u00b1 30 nm (maximal at 24 h), with a phototoxic index of 3\u20134. The susceptibility to this effect rapidly normalized within 48 h of stopping the drug. No special protection from UVA wavelengths is necessary for those taking moxifloxacin.<\/jats:p>","DOI":"10.1093\/jac\/43.suppl_2.77","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:24:55Z","timestamp":1027707895000},"page":"77-82","source":"Crossref","is-referenced-by-count":53,"title":["Fluoroquinolone phototoxicity: a comparison of moxifloxacin and lomefloxacin in normal volunteers"],"prefix":"10.1093","volume":"43","author":[{"given":"I.","family":"Man","sequence":"first","affiliation":[{"name":"Photobiology Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Photobiology Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Photobiology Unit, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1999,5,1]]},"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/43\/suppl_2\/77\/37465778\/jac_43_suppl2_77.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/43\/suppl_2\/77\/37465778\/jac_43_suppl2_77.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T02:11:50Z","timestamp":1619575910000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/43\/suppl_2\/77\/2473564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5,1]]},"references-count":0,"journal-issue":{"issue":"suppl_2","published-online":{"date-parts":[[1999,5,1]]},"published-print":{"date-parts":[[1999,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/43.suppl_2.77","relation":{},"ISSN":["1460-2091","0305-7453"],"issn-type":[{"value":"1460-2091","type":"electronic"},{"value":"0305-7453","type":"print"}],"subject":[],"published-other":{"date-parts":[[1999,5]]},"published":{"date-parts":[[1999,5,1]]}}}