{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:40:02Z","timestamp":1791333602150,"version":"4.3.1"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T00:00:00Z","timestamp":1580774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Swedish Government Funds for Clinical Research","award":["40231"],"award-info":[{"award-number":["40231"]}]},{"name":"Sk\u00e5ne University Hospital Foundations","award":["91202"],"award-info":[{"award-number":["91202"]}]},{"name":"Alfred \u00d6sterlund Foundation","award":["F2018\/2008"],"award-info":[{"award-number":["F2018\/2008"]}]},{"name":"Swedish Heart and Lung Foundation","award":["F2016\/783"],"award-info":[{"award-number":["F2016\/783"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Staphylococcus lugdunensis belongs to the CoNS group, but is regarded to be more virulent than most other CoNS. It is also remarkably susceptible to antibiotics, including penicillin G.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate different methods for penicillin susceptibility testing, to assess penicillin susceptibility rates among S. lugdunensis and to describe the clinical presentation including antibiotic treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Clinical isolates of S. lugdunensis were tested for penicillin susceptibility using disc diffusion according to CLSI (10\u2009U disc) and EUCAST (1\u2009U disc), assessment of zone-edge appearance, nitrocefin test and Etest for MIC determination. PCR of the blaZ gene was used as a reference method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 112 isolates included in the study, 67% were susceptible to penicillin G according to blaZ PCR. The EUCAST disc diffusion test had 100% sensitivity, whereas the CLSI method had one very major error with a false-susceptible isolate. When zone-edge appearance was included in the assessment, the false-susceptible isolate was correctly classified as resistant. Foreign-body infection was the most common focus of infection, affecting 49% of the participants. Only 4% of the patients were treated with penicillin G.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Penicillin susceptibility is common in S. lugdunensis and the disc diffusion method according to EUCAST had a higher sensitivity than that of CLSI. Assessment of zone-edge appearance could increase the sensitivity of the disc diffusion test. Penicillin susceptibility testing and treatment should be considered in S. lugdunensis infections.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkaa004","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T20:10:24Z","timestamp":1578427824000},"page":"1206-1211","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of penicillin G susceptibility testing methods for Staphylococcus lugdunensis"],"prefix":"10.1093","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3513-7579","authenticated-orcid":false,"given":"Malin","family":"Hagstrand Aldman","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Sk\u00e5ne University Hospital Lund, Lund, Sweden"},{"name":"Department of Clinical Sciences Lund, Division of Infection Medicine, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa 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